HitPredict

Interactor 1: HDAC1 (O09106)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: SIN3A (Q60520)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 10688671, 16103876, 10409740, 21454521, 21448134, 16109738, 11302704, 20404188, 19424149, 24240174
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hist_deacetyl~Sin3_corepress, Hist_deacetyl~Sin3a_C
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
and 11 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 482
Mm

1 1274
+ Mm
+ Hs
+ Hs
+ Mm
+ Sp
+ Ce
+ Ce
+ At
+ At
+ Sc
+ Dm
+ Hs
+ Hs
+ Sp
+ Sc
+ Dm
+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025