Interactor 1: SIN3B (O75182)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B
Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.981 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26496610, 10357820, 28514442, 10444591, 33961781, 35271311, 34709266, 40437099, 15935060, 11102443, 20585571, 23752268, 24951594, unassigned3799 |
| Identification Methods | affinity chromatography technology, biochemical, proximity labelling technology, cross-linking study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Hist_deacetyl~Sin3_corepress, Hist_deacetyl~Sin3a_C |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 3 others more... |
| Homologous interactions | 18 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
