HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.995

The method score is based on:

Property Details
Experiments 25314079, 12724404, 12398767, 9804427, 10640275, 11784859, 33961781, 14593184, 12453419, 11602581, 11118440, 18059533, 17827154, 21258344, 19182791, 26496610, 28514442, 12943729, 12920132, 10220385 and 22 others

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Identification Methods affinity chromatography technology, biochemical, pull down, cross-linking study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Hist_deacetyl~Sin3_corepress, Hist_deacetyl~Sin3a_C
Common GO terms GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
and 11 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 482
Hs

1 1273
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Sc
+ Sp
+ Ce
+ Ce
+ Sc
+ Sc
+ At
+ Dm
+ At
+ Sp
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025