HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.907

The method score is based on:

Property Details
Experiments 11468294, 9388212, 11742534, 21220115
Identification Methods affinity chromatography technology, pull down, experimental interaction detection, ion exchange chromatography, molecular sieving, transmission electron microscopy, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~fn3
Common GO terms GO:0005886 - plasma membrane
GO:0019221 - cytokine-mediated signaling pathway
GO:0038154 - interleukin-11-mediated signaling pathway
GO:0043235 - receptor complex
GO:0070102 - interleukin-6-mediated signaling pathway
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1154
Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025