HitPredict

Interactor 1: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1054 Hs			1 1273
+	Hs
		229469 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		1018652 CHD3_HUMAN (31-954): 0: 791: 28.94		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		1059812 CHD4_HUMAN (29-960): 0: 789: 28.27		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		847060 SMCA4_HUMAN (60-913): 0: 686: 31.42		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		846854 SMCA2_HUMAN (170-669): 1.05e-122: 413: 44.32		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Ce
		60807 LE418_CAEEL (38-954): 0: 725: 28.69		SIN3_CAEEL (60-1079): 0: 716: 19.90
+	Hs
		257742 SMCA1_HUMAN (1-1054): 0: 1130: 100.00		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Dm
		1097624 ISWI_DROME (44-1044): 0: 986: 71.03		Q5U0Y0_DROME (35-539): 2.36e-50: 198: 21.88
+	Ce
		60817 SWSN4_CAEEL (183-669): 4.66e-125: 417: 47.42		SIN3_CAEEL (60-1079): 0: 716: 19.90
+	Sc
		609152 ISW2_YEAST (11-1054): 0: 856: 45.76		SIN3_YEAST (20-499): 1.06e-32: 140: 14.02
+	Sc
		609080 ISW1_YEAST (70-1049): 0: 805: 47.63		SIN3_YEAST (20-499): 1.06e-32: 140: 14.02
+	Hs
		257809 CHD5_HUMAN (31-961): 0: 800: 28.13		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257774 CHD3_HUMAN (31-954): 0: 791: 28.94		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257757 SMCA4_HUMAN (60-913): 0: 686: 31.42		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Sc
		609061 CHD1_YEAST (170-735): 1.73e-129: 430: 41.95		SIN3_YEAST (20-499): 1.06e-32: 140: 14.02
+	Sc
		609060 STH1_YEAST (170-695): 4.13e-124: 413: 45.69		SIN3_YEAST (20-499): 1.06e-32: 140: 14.02
+	Hs
		257756 SMCA2_HUMAN (170-669): 1.05e-122: 413: 44.32		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15