HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	10969079, 24135036, 14581471, 14500727
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 1512
+	Hs
		647566 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Rn
		926446 MK01_RAT (10-360): 4.96e-158: 449: 99.72		KPCB_RAT (899-1509): 8.16e-127: 412: 15.40
+	Hs
		566379 MK07_HUMAN (11-355): 3.65e-140: 419: 49.28		KPCA_HUMAN (963-1509): 9.28e-133: 428: 18.93
+	At
		1259034 MPK16_ARATH (1-356): 2.44e-147: 429: 45.43		CIPKN_ARATH (1215-1512): 4.58e-120: 387: 23.75
+	Hs
		864833 MK12_HUMAN (1-359): 6.4e-140: 403: 40.22		MYLK3_HUMAN (792-1510): 2.74e-124: 410: 15.35
+	At
		1114822 MPK16_ARATH (1-356): 2.44e-147: 429: 45.43		CDPK8_ARATH (1190-1510): 4.07e-118: 383: 21.61
+	Hs
		864832 MK12_HUMAN (1-359): 6.4e-140: 403: 40.22		PKN1_HUMAN (777-1512): 3.49e-122: 407: 14.62
+	At
		1106058 MPK2_ARATH (17-360): 2.3e-143: 412: 49.57		CDPK8_ARATH (1190-1510): 4.07e-118: 383: 21.61
+	At
		1105937 MPK1_ARATH (17-360): 3.97e-141: 406: 49.42		CDPK8_ARATH (1190-1510): 4.07e-118: 383: 21.61
+	At
		1106684 MPK7_ARATH (17-357): 3.15e-139: 401: 47.23		CDPK8_ARATH (1190-1510): 4.07e-118: 383: 21.61
+	At
		1106718 MPK7_ARATH (17-357): 3.15e-139: 401: 47.23		CIPKO_ARATH (1238-1512): 2.79e-105: 345: 28.62
+	Hs
		1081922 MK14_HUMAN (18-356): 7.86e-112: 332: 48.97		PKN1_HUMAN (777-1512): 3.49e-122: 407: 14.62
+	Hs
		659033 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Hs
		647664 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Rn
		61805 MK03_RAT (15-357): 1.97e-152: 435: 88.63		A6HK01_RAT (1243-1505): 2.67e-51: 194: 43.66
+	Hs
		1026893 MK07_HUMAN (11-355): 3.65e-140: 419: 49.28		M3K2_HUMAN (1238-1505): 3.52e-50: 191: 42.13
+	At
		1105516 MPK4_ARATH (14-357): 5.23e-151: 431: 51.01		M3K1_ARATH (1241-1509): 1.4e-42: 168: 37.87
+	Sc
		618318 HOG1_YEAST (4-360): 8.23e-142: 410: 45.81		STE11_YEAST (1208-1506): 9.69e-48: 185: 34.71
+	Sc
		562684 FUS3_YEAST (13-351): 4.45e-141: 405: 49.86		STE11_YEAST (1208-1506): 9.69e-48: 185: 34.71
+	Sc
		539307 KSS1_YEAST (13-350): 3.14e-119: 350: 50.96		STE11_YEAST (1208-1506): 9.69e-48: 185: 34.71