HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: ABI2 (Q9NYB9)
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Gene: ABI2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0016477 - cell migration GO:0030027 - lamellipodium GO:0070309 - lens fiber cell morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 513
+	Hs
		710356 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ABI1_HUMAN (1-513): 1.58e-95: 300: 60.43
+	Hs
		710862 EPHB2_HUMAN (28-973): 0: 1077: 48.29		ABI1_HUMAN (1-513): 1.58e-95: 300: 60.43
+	Hs
		710627 EPHA3_HUMAN (24-976): 0: 1096: 50.98		SRC8_HUMAN (271-507): 3.77e-33: 134: 17.84
+	Hs
		710833 EPHB2_HUMAN (28-973): 0: 1077: 48.29		SRC8_HUMAN (271-507): 3.77e-33: 134: 17.84
+	Hs
		710163 EPHA2_HUMAN (1-976): 0: 1124: 100.00		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		987657 EPHA7_HUMAN (4-974): 0: 1120: 50.15		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		710527 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ITSN2_HUMAN (425-512): 2.11e-13: 75.2: 29.55
+	Hs
		931831 EPHA5_HUMAN (11-976): 0: 1115: 51.34		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		932053 EPHA4_HUMAN (1-974): 0: 1110: 50.35		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		932029 EPHB1_HUMAN (27-973): 0: 1098: 47.26		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		710618 EPHA3_HUMAN (24-976): 0: 1096: 50.98		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		931809 EPHB3_HUMAN (22-972): 0: 1040: 47.33		SRC8_HUMAN (271-507): 3.77e-33: 134: 17.84
+	Mm
		932044 EPHB2_MOUSE (28-973): 0: 1078: 48.29		GRB2_MOUSE (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		710805 EPHB2_HUMAN (28-973): 0: 1077: 48.29		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		710840 EPHB2_HUMAN (28-973): 0: 1077: 48.29		ITSN1_HUMAN (424-510): 4.45e-11: 67.9: 21.28
+	Hs
		710698 EPHA8_HUMAN (28-975): 0: 1037: 46.72		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		640141 EPHA1_HUMAN (17-967): 0: 947: 49.28		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Hs
		584528 MERTK_HUMAN (270-900): 1e-144: 458: 23.90		VAV_HUMAN (276-513): 7.12e-31: 129: 17.06
+	Hs
		572914 INSRR_HUMAN (287-911): 1.43e-146: 470: 27.55		GRB2_HUMAN (454-510): 1.09e-17: 83.7: 37.93
+	Mm
		1028469 UFO_MOUSE (264-911): 1.3e-146: 460: 24.62		GRB2_MOUSE (454-510): 1.09e-17: 83.7: 37.93