HitPredict

Interactor 1: IL3RB (P32927)
Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
Gene: CSF2RB

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15194700
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 897 Hs			1 770
+	Hs
		748673 IL3RB_HUMAN (1-897): 0: 586: 100.00		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Mm
		594822 IL4RA_MOUSE (233-893): 8.38e-51: 194: 15.52		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		820514 IL6RB_HUMAN (241-441): 5.05e-46: 180: 21.53		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		838095 I13R2_HUMAN (129-457): 7.14e-89: 289: 19.66		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		575813 IL2RB_HUMAN (248-745): 7.44e-37: 148: 16.00		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		827902 CSF3R_HUMAN (241-594): 1.88e-31: 134: 17.47		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		820515 IL6RB_HUMAN (241-441): 5.05e-46: 180: 21.53		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		575815 IL2RB_HUMAN (248-745): 7.44e-37: 148: 16.00		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		575827 IL2RB_HUMAN (248-745): 7.44e-37: 148: 16.00		STAT4_HUMAN (1-729): 0: 893: 48.44
+	Hs
		1132029 I12R2_HUMAN (242-447): 5.32e-34: 142: 16.82		STAT4_HUMAN (1-729): 0: 893: 48.44
+	Mm
		838404 PRLR_MOUSE (232-684): 1.06e-46: 179: 12.30		STA5A_MOUSE (1-734): 0: 757: 30.46
+	Hs
		596943 PRLR_HUMAN (241-733): 4.28e-47: 180: 15.27		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Mm
		593806 IL2RB_MOUSE (248-718): 9.16e-39: 154: 18.06		STA5B_MOUSE (1-734): 0: 760: 30.59
+	Mm
		593805 IL2RB_MOUSE (248-718): 9.16e-39: 154: 18.06		STA5A_MOUSE (1-734): 0: 757: 30.46
+	Hs
		619211 EPOR_HUMAN (245-685): 9.72e-41: 159: 16.42		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		575819 IL2RB_HUMAN (248-745): 7.44e-37: 148: 16.00		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		575816 IL2RB_HUMAN (248-745): 7.44e-37: 148: 16.00		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Mm
		594823 IL4RA_MOUSE (233-893): 8.38e-51: 194: 15.52		STAT6_MOUSE (1-761): 0: 668: 25.69
+	Hs
		665032 IL4RA_HUMAN (233-881): 2.9e-46: 180: 17.16		STAT6_HUMAN (1-753): 0: 627: 24.10