HitPredict

Interactor 1: K1C20 (P35900)
Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)
Gene: KRT20

Interactor 2: PERI (P41219)
Peripherin (Neurofilament 4)
Gene: PRPH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.852

Property	Details
Experiments	32296183, 32814053, unassigned1304
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005737 - cytoplasm GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 424 Hs			1 470
+	Hs
		474520 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		VIME_HUMAN (10-458): 3.82e-146: 427: 56.79
+	Hs
		437109 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C8_HUMAN (12-456): 3.41e-140: 412: 33.54
+	Hs
		436768 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		VIME_HUMAN (10-458): 3.82e-146: 427: 56.79
+	Hs
		606080 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		DESM_HUMAN (56-462): 7.23e-129: 383: 62.26
+	Hs
		436763 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C8_HUMAN (12-456): 3.41e-140: 412: 33.54
+	Hs
		777412 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		KRT84_HUMAN (22-430): 2.32e-98: 309: 32.12
+	Hs
		777397 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C79_HUMAN (4-418): 6.07e-86: 275: 31.83
+	Hs
		341740 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C75_HUMAN (4-410): 7.71e-85: 272: 33.73
+	Hs
		777391 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C72_HUMAN (9-410): 9.72e-79: 255: 30.30
+	Hs
		566336 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C5_HUMAN (62-410): 6.91e-72: 240: 35.98
+	Hs
		407255 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C6B_HUMAN (62-410): 1.61e-71: 238: 34.56
+	Hs
		777381 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C6C_HUMAN (62-410): 1.48e-71: 238: 34.56
+	Hs
		341723 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C75_HUMAN (4-410): 7.71e-85: 272: 33.73
+	Hs
		385241 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C6A_HUMAN (62-410): 2.1e-70: 235: 34.56
+	Hs
		436765 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		NFL_HUMAN (76-408): 1.05e-78: 256: 52.54
+	Hs
		436766 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		NFM_HUMAN (15-408): 5.93e-73: 249: 43.81
+	Hs
		436782 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C5_HUMAN (62-410): 6.91e-72: 240: 35.98
+	Hs
		407236 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C6B_HUMAN (62-410): 1.61e-71: 238: 34.56
+	Hs
		385215 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C6A_HUMAN (62-410): 2.1e-70: 235: 34.56
+	Mm
		1424269 K1C17_MOUSE (27-418): 1.14e-143: 418: 50.25		K2C7_MOUSE (8-408): 5.04e-69: 228: 36.88