HitPredict

Interactor 1: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 474 Hs			1 1424
+	Hs
		833958 HNF4A_HUMAN (1-474): 0: 542: 100.00		HIF1A_HUMAN (1-833): 7.92e-116: 386: 14.82
+	Hs
		625858 RXRA_HUMAN (5-377): 4.93e-125: 373: 37.01		NCOA3_HUMAN (1-1424): 3.15e-161: 525: 100.00
+	Hs
		132704 HNF4A_HUMAN (1-474): 0: 542: 100.00		BMAL1_HUMAN (6-541): 7.25e-107: 354: 18.06
+	Hs
		522840 COT1_HUMAN (22-386): 4.97e-116: 349: 33.60		NCOA3_HUMAN (1-1424): 3.15e-161: 525: 100.00
+	Mm
		1053223 HNF4G_MOUSE (52-456): 1.18e-138: 406: 74.57		Q05BA5_MOUSE (1-1424): 1.6e-137: 460: 80.73
+	Mm
		63118 HNF4G_MOUSE (52-456): 1.18e-138: 406: 74.57		A5D6Q2_MOUSE (50-1424): 1.27e-129: 437: 80.69
+	Hs
		693260 HNF4A_HUMAN (1-474): 0: 542: 100.00		ARNT_HUMAN (6-691): 5.7e-78: 277: 14.95
+	Hs
		625841 RXRA_HUMAN (5-377): 4.93e-125: 373: 37.01		NPAS2_HUMAN (19-850): 1.63e-110: 371: 16.09
+	Hs
		132699 RXRA_HUMAN (5-377): 4.93e-125: 373: 37.01		BMAL1_HUMAN (6-541): 7.25e-107: 354: 18.06
+	Hs
		192898 RXRA_HUMAN (5-377): 4.93e-125: 373: 37.01		CLOCK_HUMAN (1-823): 1.45e-78: 280: 13.22
+	Dm
		892165 HNF4_DROME (57-428): 1.37e-119: 367: 60.57		SIMA_DROME (6-779): 9.51e-75: 276: 13.19
+	Hs
		833993 HNF4A_HUMAN (1-474): 0: 542: 100.00		KMT2C_HUMAN (471-1383): 1.97e-11: 71.3: 12.87
+	Hs
		833953 HNF4A_HUMAN (1-474): 0: 542: 100.00		NCOA1_HUMAN (1054-1422): 8.77e-11: 69.1: 13.82
+	Hs
		833949 HNF4A_HUMAN (1-474): 0: 542: 100.00		NCOA2_HUMAN (381-1311): 1.14e-09: 65.3: 9.75
+	Hs
		522808 COT1_HUMAN (22-386): 4.97e-116: 349: 33.60		AHR_HUMAN (12-795): 5.03e-71: 258: 11.62
+	Hs
		1127873 HNF4G_HUMAN (52-456): 5.7e-137: 402: 73.58		NCOA1_HUMAN (1054-1422): 8.77e-11: 69.1: 13.82
+	Hs
		625823 RXRA_HUMAN (5-377): 4.93e-125: 373: 37.01		NCOA1_HUMAN (1054-1422): 8.77e-11: 69.1: 13.82
+	Hs
		625819 RXRA_HUMAN (5-377): 4.93e-125: 373: 37.01		NCOA2_HUMAN (381-1311): 1.14e-09: 65.3: 9.75
+	Hs
		704533 RXRB_HUMAN (16-377): 3.45e-119: 360: 38.03		NCOA1_HUMAN (1054-1422): 8.77e-11: 69.1: 13.82
+	Hs
		522821 COT1_HUMAN (22-386): 4.97e-116: 349: 33.60		NCOA2_HUMAN (381-1311): 1.14e-09: 65.3: 9.75