HitPredict

Interactor 1: UBC9 (P50623)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (Ubiquitin carrier protein 9) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase)
Gene: UBC9

Interactor 2: UBA2 (P52488)
Ubiquitin-activating enzyme E1-like (Polymerase-interacting protein 2) (SMT3-activating enzyme subunit 2)
Gene: UBA2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	15738391, 21518767, 12354763, 26633173, 9341106, 21209884
Identification Methods	pull down, enzymatic study, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 157 Sc			1 636
+	Hs
		1381215 UB2E3_HUMAN (3-156): 6.7e-69: 208: 31.17		SAE2_HUMAN (9-636): 0: 552: 32.57
+	Hs
		993787 UBC9_HUMAN (1-156): 1.26e-69: 208: 56.41		SAE2_HUMAN (9-636): 0: 552: 32.57
+	Dm
		1268442 Q7KNM2_DROME (1-156): 2.5e-73: 218: 53.85		Q7KUA4_DROME (10-614): 1.32e-176: 520: 29.43
+	At
		1192766 SCE1_ARATH (2-155): 2.61e-73: 218: 59.74		SAE2_ARATH (16-544): 1.74e-160: 478: 32.68
+	Hs
		982256 UB2D2_HUMAN (4-156): 2.56e-74: 220: 32.68		UBA3_HUMAN (293-526): 4.52e-48: 176: 14.98
+	Hs
		647684 UB2D4_HUMAN (4-156): 2.18e-75: 223: 33.33		UBA1_HUMAN (4-153): 7.44e-32: 134: 20.00
+	Hs
		647506 UB2D1_HUMAN (4-156): 1.2e-74: 221: 33.99		UBA1_HUMAN (4-153): 7.44e-32: 134: 20.00
+	Hs
		647533 UB2D2_HUMAN (4-156): 2.56e-74: 220: 32.68		UBA1_HUMAN (4-153): 7.44e-32: 134: 20.00
+	Hs
		647521 UB2D3_HUMAN (4-156): 3.19e-73: 217: 32.68		UBA1_HUMAN (4-153): 7.44e-32: 134: 20.00
+	Sc
		649508 UBC9_YEAST (1-157): 1.75e-76: 226: 100.00		UBA1_YEAST (4-154): 5.66e-29: 125: 20.40
+	Hs
		647626 UB2E2_HUMAN (3-156): 2.99e-69: 209: 31.17		UBA1_HUMAN (4-153): 7.44e-32: 134: 20.00
+	Sc
		585681 UBC4_YEAST (1-156): 2.8e-73: 217: 33.33		UBA1_YEAST (4-154): 5.66e-29: 125: 20.40
+	Hs
		647538 UBC9_HUMAN (1-156): 1.26e-69: 208: 56.41		UBA1_HUMAN (4-153): 7.44e-32: 134: 20.00
+	Hs
		647619 UB2E3_HUMAN (3-156): 6.7e-69: 208: 31.17		UBA1_HUMAN (4-153): 7.44e-32: 134: 20.00
+	Hs
		48347 UB2D1_HUMAN (4-156): 1.2e-74: 221: 33.99		UBA6_HUMAN (4-328): 4.03e-27: 119: 12.57
+	Hs
		48351 UB2D2_HUMAN (4-156): 2.56e-74: 220: 32.68		UBA6_HUMAN (4-328): 4.03e-27: 119: 12.57
+	Hs
		647508 UB2E1_HUMAN (3-156): 2.88e-67: 204: 31.82		UBA1_HUMAN (4-153): 7.44e-32: 134: 20.00
+	Hs
		48349 UB2D3_HUMAN (4-156): 3.19e-73: 217: 32.68		UBA6_HUMAN (4-328): 4.03e-27: 119: 12.57
+	Hs
		833587 UB2E1_HUMAN (3-156): 2.88e-67: 204: 31.82		UBA7_HUMAN (4-153): 2.91e-30: 129: 17.33
+	Sp
		314596 UBC4_SCHPO (4-156): 2.89e-73: 217: 33.33		UBA1_SCHPO (4-153): 3.24e-24: 110: 16.67