Protein: IRGM
Immunity-related GTPase family M protein (EC 3.6.5.-) (Immunity-related GTPase family M protein 1) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47 homolog) (LRG-47)

Gene: IRGM
Organism: Homo sapiens
Interactions: 26
UniProt ID: A1A4Y4

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000139 - Golgi membrane
GO:0000421 - autophagosome membrane
GO:0001891 - phagocytic cup
GO:0001934 - positive regulation of protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

50003

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

2

2

Small-scale

0.646

High

50005

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

2

2

Small-scale

0.624

High

49982

IRGM
Immunity-related GTPase family M protein

1

2

Small-scale

0.618

High

49983

TLR3
Toll-like receptor 3

2

0

Small-scale

0.598

High

49986

RIGI
Antiviral innate immune response receptor RIG-I

2

0

Small-scale

0.598

High

49998

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

2

Small-scale

0.561

High

49989

SQSTM
Sequestosome-1

2

0

Small-scale

0.559

High

49984

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

0

Small-scale

0.537

High

49996

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.537

High

49999

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

0

Small-scale

0.529

High

50001

ATG10
Ubiquitin-like-conjugating enzyme ATG10

1

0

Small-scale

0.529

High

50002

ATG5
Autophagy protein 5

1

0

Small-scale

0.529

High

50006

SHLB1
Endophilin-B1

1

0

Small-scale

0.529

High

49995

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

0

High-throughput

0.513

High

49987

COF1
Cofilin-1

1

0

High-throughput

0.493

High

49997

OPTN
Optineurin

1

0

High-throughput

0.493

High

49991

A16L1
Autophagy-related protein 16-1

1

1

Small-scale

0.479

High

50004

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.479

High

49985

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

49990

BECN1
Beclin-1

1

0

Small-scale

0.458

High

49992

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

Small-scale

0.458

High

49993

TAXB1
Tax1-binding protein 1

1

0

Small-scale

0.458

High

50000

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

Small-scale

0.458

High

49988

HXD13
Homeobox protein Hox-D13

1

0

High-throughput

0.279

Low

49994

RLGPB
Ral GTPase-activating protein subunit beta

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025