Protein: TSSC4
U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein)

Gene: TSSC4
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q9Y5U2

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000387 - spliceosomal snRNP assembly
GO:0005634 - nucleus
GO:0005681 - spliceosomal complex
GO:0005682 - U5 snRNP

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1241875

PRP8
Pre-mRNA-processing-splicing factor 8

7

0

High-throughput

0.909

High

289743

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

6

2

High-throughput

0.729

High

321710

PRP6
Pre-mRNA-processing factor 6

5

2

High-throughput

0.712

High

1138826

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

6

0

High-throughput

0.697

High

1387666

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

4

2

High-throughput

0.694

High

1419990

CRNL1
Crooked neck-like protein 1

4

2

High-throughput

0.694

High

1439445

SYF1
Pre-mRNA-splicing factor SYF1

4

2

High-throughput

0.694

High

1491031

AAR2
Protein AAR2 homolog

5

0

High-throughput

0.684

High

351194

ECD
Protein ecdysoneless homolog

5

0

High-throughput

0.682

High

1201300

EAPP
E2F-associated phosphoprotein

5

0

High-throughput

0.682

High

1412063

WDR83
WD repeat domain-containing protein 83

3

3

High-throughput

0.667

High

245178

AQR
RNA helicase aquarius

4

0

High-throughput

0.664

High

335945

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

4

0

High-throughput

0.664

High

1111395

SNW1
SNW domain-containing protein 1

4

0

High-throughput

0.664

High

1404551

CDC5L
Cell division cycle 5-like protein

4

0

High-throughput

0.664

High

1411678

GPTC1
G patch domain-containing protein 1

4

0

High-throughput

0.664

High

1461669

ISY1
Pre-mRNA-splicing factor ISY1 homolog

4

0

High-throughput

0.664

High

974099

RUXF
Small nuclear ribonucleoprotein F

3

2

High-throughput

0.662

High

1451090

RBM22
Pre-mRNA-splicing factor RBM22

4

0

High-throughput

0.661

High

138789

IMA4
Importin subunit alpha-4

2

1

High-throughput

0.640

High

351368

SYF2
Pre-mRNA-splicing factor SYF2

3

0

High-throughput

0.638

High

1013977

TXN4A
Thioredoxin-like protein 4A

3

0

High-throughput

0.638

High

1095203

RED
Protein Red

3

0

High-throughput

0.638

High

575224

IDE
Insulin-degrading enzyme

3

0

High-throughput

0.634

High

973860

RUXE
Small nuclear ribonucleoprotein E

3

0

High-throughput

0.634

High

251054

PRP17
Pre-mRNA-processing factor 17

4

3

High-throughput

0.633

High

1434800

DHX35
Probable ATP-dependent RNA helicase DHX35

4

2

High-throughput

0.633

High

991279

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

1

High-throughput

0.628

High

974706

SMD2
Small nuclear ribonucleoprotein Sm D2

3

0

High-throughput

0.628

High

1414639

DDX23
Probable ATP-dependent RNA helicase DDX23

3

0

High-throughput

0.622

High

1452218

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

3

0

High-throughput

0.622

High

574537

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

1

High-throughput

0.611

High

974225

RUXG
Small nuclear ribonucleoprotein G

2

4

High-throughput

0.611

High

974881

SMD3
Small nuclear ribonucleoprotein Sm D3

2

3

High-throughput

0.611

High

482986

TPM1
Tropomyosin alpha-1 chain

3

1

High-throughput

0.609

High

1180526

C19L2
CWF19-like protein 2

3

1

High-throughput

0.609

High

1229519

C19L1
CWF19-like protein 1

3

1

High-throughput

0.609

High

749827

CADH5
Cadherin-5

2

0

High-throughput

0.602

High

1438641

GPBL1
Vasculin-like protein 1

2

0

High-throughput

0.602

High

1462375

PPIE
Peptidyl-prolyl cis-trans isomerase E

2

0

High-throughput

0.602

High

298127

SPF27
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.585

High

833572

BUD31
Protein BUD31 homolog

2

0

High-throughput

0.585

High

1394570

RSRC1
Serine/Arginine-related protein 53

2

0

High-throughput

0.585

High

1458264

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.585

High

1491518

PAXB1
PAX3- and PAX7-binding protein 1

2

0

High-throughput

0.585

High

1090996

TRAF2
TNF receptor-associated factor 2

1

1

High-throughput

0.573

High

1094001

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.573

High

1234637

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

2

1

High-throughput

0.558

High

1452498

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.549

High

1049073

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

587273

ITF2
Transcription factor 4

1

0

High-throughput

0.536

High

911444

IMA5
Importin subunit alpha-5

1

1

High-throughput

0.536

High

1389437

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

High-throughput

0.523

High

131085

TULP2
Tubby-related protein 2

1

0

High-throughput

0.513

High

273960

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.513

High

391532

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

682124

RBTN1
Rhombotin-1

1

0

High-throughput

0.513

High

848757

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

1136426

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.513

High

1382561

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

1387431

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.513

High

1449396

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.513

High

1453667

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.513

High

447904

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.489

High

1153151

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.486

High

1394289

GMCL1
Germ cell-less protein-like 1

1

1

High-throughput

0.481

High

423544

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

222552

PLRG1
Pleiotropic regulator 1

1

1

High-throughput

0.479

High

974502

SMD1
Small nuclear ribonucleoprotein Sm D1

1

3

High-throughput

0.479

High

1128167

DHX8
ATP-dependent RNA helicase DHX8

1

2

High-throughput

0.479

High

1365871

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

2

High-throughput

0.479

High

1459473

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1462087

PRP19
Pre-mRNA-processing factor 19

1

1

High-throughput

0.479

High

1490465

RUVB2
RuvB-like 2

1

2

High-throughput

0.479

High

1490529

RUVB1
RuvB-like 1

1

2

High-throughput

0.479

High

1491050

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

3

High-throughput

0.479

High

1200452

Q53SE7
Germ cell-less homolog 1

1

1

High-throughput

0.470

High

243423

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

260659

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

294594

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

317052

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

335528

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

373630

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

401774

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

935662

MFAP1
Microfibrillar-associated protein 1

1

0

High-throughput

0.458

High

1026611

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1332864

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.458

High

1386820

S7A6O
Probable RNA polymerase II nuclear localization protein SLC7A6OS

1

0

High-throughput

0.458

High

1435511

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1439058

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

0

High-throughput

0.458

High

1491741

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

0

High-throughput

0.458

High

71631

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

4

High-throughput

0.445

High

1208204

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

1

1

High-throughput

0.445

High

647690

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

High-throughput

0.438

High

1227789

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

58977

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.426

High

920404

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.426

High

1029795

FOXK2
Forkhead box protein K2

1

0

High-throughput

0.426

High

1293519

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.426

High

1335938

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

1

0

High-throughput

0.426

High

1416414

CDK19
Cyclin-dependent kinase 19

1

0

High-throughput

0.426

High

1460080

ZNHI2
Zinc finger HIT domain-containing protein 2

5

0

High-throughput

0.371

High

1356591

CCD12
Coiled-coil domain-containing protein 12

3

0

High-throughput

0.347

High

1411398

LZTS2
Leucine zipper putative tumor suppressor 2

3

0

High-throughput

0.347

High

1339415

GP156
Probable G-protein coupled receptor 156

3

0

High-throughput

0.345

High

1347489

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.326

High

1386759

AP2M1
AP-2 complex subunit mu

2

0

High-throughput

0.318

High

1458227

NCDN
Neurochondrin

2

0

High-throughput

0.318

High

1063732

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.299

High

1117541

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

High-throughput

0.282

High

1179889

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1231496

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

1242113

TTC27
Tetratricopeptide repeat protein 27

1

0

High-throughput

0.279

Low

1349006

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

301781

WFS1
Wolframin

1

0

High-throughput

0.268

Low

705625

GRN
Progranulin

1

0

High-throughput

0.268

Low

1290871

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

1281682

ZER1
Protein zer-1 homolog

1

0

High-throughput

0.232

Low

1390931

LRC46
Leucine-rich repeat-containing protein 46

1

0

High-throughput

0.232

Low

1403193

AEDO
2-aminoethanethiol dioxygenase

1

0

High-throughput

0.232

Low

1453771

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025