Protein: DPOLB
DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)

Gene: DPOLB, POLB
Organism: Homo sapiens
Interactions: 61
UniProt ID: P06746

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0003684 - damaged DNA binding
GO:0003887 - DNA-directed DNA polymerase activity
GO:0003906 - DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

446508

XRCC1
DNA repair protein XRCC1

13

1

Small-scale

0.985

High

446499

PARP1
Poly [ADP-ribose] polymerase 1

5

2

Small-scale

0.721

High

446541

PNKP
Bifunctional polynucleotide phosphatase/kinase

4

1

Small-scale

0.702

High

446515

DNLI3
DNA ligase 3

4

2

High-throughput

0.691

High

446546

TYDP1
Tyrosyl-DNA phosphodiesterase 1

4

0

High-throughput

0.670

High

446500

H2A1
Histone H2A type 1

3

1

High-throughput

0.667

High

446504

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

3

1

High-throughput

0.667

High

446509

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

3

1

High-throughput

0.667

High

446525

SSRP1
FACT complex subunit SSRP1

3

2

High-throughput

0.667

High

446532

APTX
Aprataxin

3

1

High-throughput

0.667

High

446549

PARP2
Poly [ADP-ribose] polymerase 2

3

1

High-throughput

0.667

High

446551

SP16H
FACT complex subunit SPT16

3

1

High-throughput

0.667

High

446535

APLF
Aprataxin and PNK-like factor

4

0

High-throughput

0.661

High

446511

TPP2
Tripeptidyl-peptidase 2

3

0

High-throughput

0.654

High

446521

XPC
DNA repair protein complementing XP-C cells

3

0

High-throughput

0.638

High

446503

PCNA
Proliferating cell nuclear antigen

2

4

Small-scale

0.624

High

446510

APEX1
DNA repair nuclease/redox regulator APEX1

3

0

Small-scale

0.620

High

446514

CETN2
Centrin-2

2

1

High-throughput

0.611

High

446534

H2A2B
Histone H2A type 2-B

2

1

High-throughput

0.611

High

446526

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.578

High

446519

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.550

High

446545

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

Small-scale

0.549

High

446513

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.537

High

446528

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.536

High

446529

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.536

High

446531

H2B2E
Histone H2B type 2-E

1

5

High-throughput

0.536

High

331947

KAT7
Histone acetyltransferase KAT7

1

0

High-throughput

0.518

High

446522

TLE1
Transducin-like enhancer protein 1

1

0

High-throughput

0.518

High

219907

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

446502

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

446506

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

446520

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

446523

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

446544

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

446527

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

1

Small-scale

0.501

High

446533

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

Small-scale

0.501

High

253182

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.480

High

261689

HUS1
Checkpoint protein HUS1

1

0

Small-scale

0.480

High

446537

NEIL1
Endonuclease 8-like 1

1

0

Small-scale

0.480

High

446542

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.480

High

446550

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.480

High

259312

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

446518

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

446530

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.479

High

446548

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

247603

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

446507

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

446512

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

446517

H4
Histone H4

1

0

High-throughput

0.458

High

446524

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

446538

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

Small-scale

0.458

High

446539

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.458

High

446540

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

446543

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

446547

DNM3B
DNA

1

0

Small-scale

0.458

High

446498

HMGB1
High mobility group protein B1

1

3

Small-scale

0.445

High

446501

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

446505

UNG
Uracil-DNA glycosylase

1

0

Small-scale

0.426

High

446516

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

3

0

High-throughput

0.347

High

446536

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

301302

WFS1
Wolframin

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025