Protein: APLF
Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1)

Gene: APLF
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q8IW19

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000166 - nucleotide binding
GO:0003906 - DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004520 - DNA endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

487501

PARP1
Poly [ADP-ribose] polymerase 1

7

4

Small-scale

0.753

High

559411

XRCC5
X-ray repair cross-complementing protein 5

7

1

Small-scale

0.748

High

558254

XRCC6
X-ray repair cross-complementing protein 6

7

1

Small-scale

0.742

High

892694

DNLI4
DNA ligase 4

6

1

Small-scale

0.730

High

617713

XRCC1
DNA repair protein XRCC1

9

0

Small-scale

0.723

High

1104917

XRCC4
DNA repair protein XRCC4

7

0

Small-scale

0.712

High

892590

DNLI3
DNA ligase 3

5

1

Small-scale

0.709

High

1309441

PARP2
Poly [ADP-ribose] polymerase 2

5

3

Small-scale

0.709

High

1292490

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

6

0

Small-scale

0.697

High

277734

H2AY
Core histone macro-H2A.1

4

6

Small-scale

0.694

High

502417

H2A1
Histone H2A type 1

3

4

High-throughput

0.667

High

1309435

H2B1A
Histone H2B type 1-A

3

1

High-throughput

0.667

High

1309440

H2AW
Core histone macro-H2A.2

3

6

High-throughput

0.667

High

446535

DPOLB
DNA polymerase beta

4

0

High-throughput

0.661

High

1127732

HLTF
Helicase-like transcription factor

4

0

High-throughput

0.661

High

832917

CETN2
Centrin-2

3

0

High-throughput

0.638

High

1032834

XPC
DNA repair protein complementing XP-C cells

3

0

High-throughput

0.638

High

1065286

SSRP1
FACT complex subunit SSRP1

3

0

High-throughput

0.638

High

1309439

TYDP1
Tyrosyl-DNA phosphodiesterase 1

3

0

High-throughput

0.638

High

1309444

SP16H
FACT complex subunit SPT16

3

0

High-throughput

0.638

High

1162823

H2A2C
Histone H2A type 2-C

2

4

Small-scale

0.611

High

1307268

H2A2B
Histone H2A type 2-B

2

4

High-throughput

0.611

High

370085

CYTS
Cystatin-S

3

1

High-throughput

0.609

High

633326

MSH3
DNA mismatch repair protein Msh3

2

0

High-throughput

0.602

High

1161929

H31T
Histone H3.1t

2

2

Small-scale

0.584

High

1216223

H37
Histone H3-7

2

2

High-throughput

0.552

High

542107

TOP1
DNA topoisomerase 1

2

0

Small-scale

0.547

High

419068

H2A1B
Histone H2A type 1-B/E

1

4

High-throughput

0.536

High

1232691

H2A2A
Histone H2A type 2-A

1

4

High-throughput

0.536

High

1102203

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.501

High

1309446

PARP3
Protein mono-ADP-ribosyltransferase PARP3

1

3

Small-scale

0.501

High

370211

CYTN
Cystatin-SN

1

1

High-throughput

0.489

High

1309437

GMCL1
Germ cell-less protein-like 1

1

1

High-throughput

0.481

High

422518

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1309432

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

449748

H2B1J
Histone H2B type 1-J

1

1

High-throughput

0.479

High

998513

H31
Histone H3.1

1

2

High-throughput

0.479

High

1200430

Q53SE7
Germ cell-less homolog 1

1

1

High-throughput

0.470

High

1309442

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

1008223

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.445

High

332420

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

0

High-throughput

0.426

High

340003

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

0

High-throughput

0.426

High

589094

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.426

High

695879

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.426

High

768591

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.426

High

854885

RECQ1
ATP-dependent DNA helicase Q1

1

0

Small-scale

0.426

High

959852

RS3A
Small ribosomal subunit protein eS1

1

0

Small-scale

0.426

High

994641

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.426

High

1141392

WDR43
WD repeat-containing protein 43

1

0

High-throughput

0.426

High

1309431

WDR75
WD repeat-containing protein 75

1

0

High-throughput

0.426

High

1309433

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

0

High-throughput

0.426

High

1309434

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

0

High-throughput

0.426

High

1309438

NOL11
Nucleolar protein 11

1

0

High-throughput

0.426

High

1309443

TIM
Protein timeless homolog

1

0

High-throughput

0.426

High

1309445

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

0

High-throughput

0.426

High

1309436

PAUF
Pancreatic adenocarcinoma up-regulated factor

3

0

High-throughput

0.347

High


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Last updated: 11Aug2025