Protein: APTX
Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)

Gene: APTX
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q7Z2E3

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000785 - chromatin
GO:0003684 - damaged DNA binding
GO:0003682 - chromatin binding
GO:0003690 - double-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

617709

XRCC1
DNA repair protein XRCC1

6

1

Small-scale

0.747

High

1104913

XRCC4
DNA repair protein XRCC4

7

1

Small-scale

0.746

High

487466

PARP1
Poly [ADP-ribose] polymerase 1

3

4

Small-scale

0.692

High

446532

DPOLB
DNA polymerase beta

3

1

High-throughput

0.667

High

1275325

PNMA1
Paraneoplastic antigen Ma1

2

2

High-throughput

0.654

High

892585

DNLI3
DNA ligase 3

3

3

Small-scale

0.650

High

1275349

PNMA3
Paraneoplastic antigen Ma3

2

2

High-throughput

0.606

High

1275350

KIF3A
Kinesin-like protein KIF3A

2

0

High-throughput

0.602

High

396404

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

414097

P53
Cellular tumor antigen p53

1

0

Small-scale

0.561

High

1275327

FAD1
FAD synthase

2

1

High-throughput

0.553

High

323456

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

High-throughput

0.541

High

161878

IMPA2
Inositol monophosphatase 2

1

1

High-throughput

0.536

High

369471

AACT
Alpha-1-antichymotrypsin

1

3

High-throughput

0.536

High

424218

S10A8
Protein S100-A8

1

2

High-throughput

0.536

High

445014

S10A9
Protein S100-A9

1

4

High-throughput

0.536

High

635609

FILA
Filaggrin

1

2

High-throughput

0.536

High

713402

SPB3
Serpin B3

1

3

High-throughput

0.536

High

724594

S10A7
Protein S100-A7

1

4

High-throughput

0.536

High

892690

DNLI4
DNA ligase 4

1

3

High-throughput

0.536

High

1062251

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

High-throughput

0.536

High

1065261

SSRP1
FACT complex subunit SSRP1

1

2

High-throughput

0.536

High

1163015

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1275323

S1A7A
Protein S100-A7A

1

4

High-throughput

0.536

High

1275326

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.536

High

1275331

SPB12
Serpin B12

1

3

High-throughput

0.536

High

1275347

CBPA4
Carboxypeptidase A4

1

2

High-throughput

0.536

High

1275351

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.536

High

250679

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

370322

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

423671

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

443077

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.513

High

729579

CASPE
Caspase-14

1

0

High-throughput

0.513

High

1213757

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.513

High

1256951

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

1275336

RNAS7
Ribonuclease 7

1

0

High-throughput

0.513

High

1275339

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.513

High

1275342

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.513

High

1275343

IL36G
Interleukin-36 gamma

1

0

High-throughput

0.513

High

246246

MABP1
Mitogen-activated protein kinase-binding protein 1

1

1

High-throughput

0.508

High

586316

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.508

High

1217472

CE350
Centrosome-associated protein 350

1

1

High-throughput

0.508

High

1275341

PICK1
PRKCA-binding protein

1

1

High-throughput

0.508

High

1275348

ZN639
Zinc finger protein 639

1

1

High-throughput

0.508

High

210760

KLK10
Kallikrein-10

1

1

High-throughput

0.489

High

261631

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

485800

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

652340

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.489

High

874805

SPB4
Serpin B4

1

3

High-throughput

0.489

High

962975

CH10
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.489

High

1009671

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.489

High

1275334

SORT
Sortilin

1

1

High-throughput

0.489

High

388077

MBP
Myelin basic protein

1

0

High-throughput

0.486

High

1275337

TSYL2
Testis-specific Y-encoded-like protein 2

1

0

High-throughput

0.486

High

1275345

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

0

High-throughput

0.486

High

761734

HSP74
Heat shock 70 kDa protein 4

1

4

Small-scale

0.479

High

851779

NKX21
Homeobox protein Nkx-2.1

1

3

High-throughput

0.479

High

979890

H4
Histone H4

1

1

High-throughput

0.479

High

1275346

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1275324

CNTRB
Centrobin

1

1

High-throughput

0.464

High

285681

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.458

High

401045

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

1275333

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

1275338

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1275340

DDX21
Nucleolar RNA helicase 2

1

0

Small-scale

0.458

High

1275344

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

75682

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

620441

NUCL
Nucleolin

1

0

Small-scale

0.426

High

69506

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

1275330

CCD43
Coiled-coil domain-containing protein 43

1

2

High-throughput

0.407

High

1275329

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.328

High

276597

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

627134

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.279

Low

718416

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

839575

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.279

Low

1180080

SMTL2
Smoothelin-like protein 2

1

0

High-throughput

0.279

Low

1275328

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

1275332

GSDMA
Gasdermin-A

1

0

High-throughput

0.279

Low

1275335

SYT17
Synaptotagmin-17

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025