Protein: HXK1
Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A)

Gene: HXK1, HK1
Organism: Homo sapiens
Interactions: 143
UniProt ID: P19367

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0002720 - positive regulation of cytokine production involved in immune response
GO:0004340 - glucokinase activity
GO:0004396 - hexokinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

583330

HKDC1
Hexokinase HKDC1

3

12

High-throughput

0.861

High

583282

HXK1
Hexokinase-1

3

12

Small-scale

0.817

High

583304

HXK2
Hexokinase-2

2

12

High-throughput

0.811

High

583305

HXK3
Hexokinase-3

2

12

High-throughput

0.811

High

226486

PRKN
E3 ubiquitin-protein ligase parkin

5

4

Small-scale

0.702

High

583317

CAV1
Caveolin-1

2

2

High-throughput

0.628

High

583285

VDAC1
Voltage-dependent anion-selective channel protein 1

2

6

High-throughput

0.621

High

583294

SYUA
Alpha-synuclein

2

0

High-throughput

0.602

High

583360

ASPC1
Tether containing UBX domain for GLUT4

2

0

High-throughput

0.602

High

394090

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.577

High

583326

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

1

High-throughput

0.571

High

325029

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.559

High

547698

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.554

High

583300

DNLI4
DNA ligase 4

1

1

High-throughput

0.552

High

447653

ENOG
Gamma-enolase

1

5

High-throughput

0.541

High

568533

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

High-throughput

0.536

High

583327

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.536

High

583353

PSKH2
Serine/threonine-protein kinase H2

1

2

High-throughput

0.536

High

583383

VDAC3
Voltage-dependent anion-selective channel protein 3

1

6

High-throughput

0.536

High

345893

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.521

High

528517

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

259416

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.513

High

583301

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

583324

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

583357

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

583363

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

165927

PER2
Period circadian protein homolog 2

1

0

Small-scale

0.493

High

522760

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

Small-scale

0.493

High

583316

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.493

High

583362

DYH6
Dynein axonemal heavy chain 6

1

0

High-throughput

0.493

High

583359

TX101
Testis-expressed protein 101

1

1

High-throughput

0.489

High

157523

MGST3
Glutathione S-transferase 3, mitochondrial

1

1

High-throughput

0.479

High

167665

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

1

High-throughput

0.479

High

322170

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

337915

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

349868

RASK
GTPase KRas

1

2

High-throughput

0.479

High

373657

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

384241

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

503410

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

545202

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.479

High

569161

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

574590

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.479

High

583286

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

583290

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

583295

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

583297

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.479

High

583299

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

583310

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

583311

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

583313

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

Small-scale

0.479

High

583318

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

583320

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

583325

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

High-throughput

0.479

High

583331

MIDN
Midnolin

1

1

High-throughput

0.479

High

583335

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

583341

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.479

High

583342

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.479

High

583345

FBF1
Fas-binding factor 1

1

1

High-throughput

0.479

High

583348

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

583351

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

583371

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

583373

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

583375

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

5

High-throughput

0.479

High

583379

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.479

High

583380

TES
Testin

1

1

High-throughput

0.479

High

583381

MAGD2
Melanoma-associated antigen D2

1

3

High-throughput

0.479

High

583384

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

583387

MTCH2
Mitochondrial carrier homolog 2

1

3

High-throughput

0.479

High

583354

RSF1
Remodeling and spacing factor 1

1

1

High-throughput

0.470

High

118192

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

119156

LEG9
Galectin-9

1

0

High-throughput

0.458

High

164777

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.458

High

173551

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

261955

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

264537

MTX2
Metaxin-2

1

0

High-throughput

0.458

High

329341

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

456802

FURIN
Furin

1

0

High-throughput

0.458

High

573562

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

575257

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

583292

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

583293

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

583298

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

583302

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

583306

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

583308

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

583312

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

583315

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.458

High

583319

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

583321

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

583329

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.458

High

583333

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

583334

CDC73
Parafibromin

1

0

High-throughput

0.458

High

583339

CNTRL
Centriolin

1

0

High-throughput

0.458

High

583346

TITIN
Titin

1

0

High-throughput

0.458

High

583347

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

583349

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

583352

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.458

High

583355

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

583356

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

583367

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

High-throughput

0.458

High

583368

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.458

High

583370

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

583374

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.458

High

583377

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

583378

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

583385

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

496270

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

583332

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

583361

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

551916

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

583284

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.437

High

583288

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

583289

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.437

High

583291

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

583296

MAGA3
Melanoma-associated antigen 3

1

3

Small-scale

0.437

High

583303

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.437

High

583309

MAX
Protein max

1

2

High-throughput

0.437

High

583323

CUL4A
Cullin-4A

1

3

High-throughput

0.437

High

583337

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

583340

LRC49
Leucine-rich repeat-containing protein 49

1

1

High-throughput

0.437

High

583344

ARL10
ADP-ribosylation factor-like protein 10

1

2

High-throughput

0.437

High

583365

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

583376

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.437

High

583382

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.437

High

583386

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.437

High

583283

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

99554

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

583336

CLC4G
C-type lectin domain family 4 member G

1

1

Small-scale

0.407

High

583358

IFT27
Intraflagellar transport protein 27 homolog

1

1

High-throughput

0.407

High

64047

AQ12B
Aquaporin-12B

1

0

High-throughput

0.279

Low

583287

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.249

Low

583307

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

583314

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.249

Low

583328

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

583338

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

583364

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

583369

ZFP14
Zinc finger protein 14 homolog

1

0

High-throughput

0.249

Low

583372

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.249

Low

583350

SCMH1
Polycomb protein SCMH1

1

0

High-throughput

0.238

Low

583366

RETR1
Reticulophagy regulator 1

1

0

Small-scale

0.238

Low

583322

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.232

Low

583343

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024