Protein: VP26C
Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A)

Gene: VP26C, VPS26C
Organism: Homo sapiens
Interactions: 73
UniProt ID: O14972

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005768 - endosome
GO:0006886 - intracellular protein transport
GO:0032456 - endocytic recycling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

171114

VPS29
Vacuolar protein sorting-associated protein 29

5

8

High-throughput

0.714

High

171113

COMD3
COMM domain-containing protein 3

5

1

High-throughput

0.712

High

171051

CCD22
Coiled-coil domain-containing protein 22

5

4

High-throughput

0.709

High

171052

VP26A
Vacuolar protein sorting-associated protein 26A

1

4

High-throughput

0.698

High

171075

CCD93
Coiled-coil domain-containing protein 93

4

1

High-throughput

0.691

High

171106

COMD4
COMM domain-containing protein 4

5

0

High-throughput

0.686

High

171084

COMD6
COMM domain-containing protein 6

4

0

High-throughput

0.667

High

171089

COMD1
COMM domain-containing protein 1

4

0

High-throughput

0.667

High

171083

VP35L
VPS35 endosomal protein-sorting factor-like

3

0

High-throughput

0.643

High

171111

PALS2
Protein PALS2

1

0

High-throughput

0.584

High

171048

MDM4
Protein Mdm4

2

0

High-throughput

0.580

High

171054

XPA
DNA repair protein complementing XP-A cells

2

0

High-throughput

0.580

High

171065

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

171090

ZN655
Zinc finger protein 655

2

0

High-throughput

0.580

High

171118

COMDA
COMM domain-containing protein 10

2

6

High-throughput

0.574

High

171055

DNJB2
DnaJ homolog subfamily B member 2

1

1

High-throughput

0.541

High

171074

SETMR
Histone-lysine N-methyltransferase SETMAR

1

1

High-throughput

0.541

High

171108

ASH1L
Histone-lysine N-methyltransferase ASH1L

1

2

High-throughput

0.541

High

171062

PMS2
Mismatch repair endonuclease PMS2

1

0

High-throughput

0.518

High

171080

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.518

High

171081

NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

1

0

High-throughput

0.518

High

171092

MYRIP
Rab effector MyRIP

1

0

High-throughput

0.518

High

171103

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.518

High

171104

CIPC
CLOCK-interacting pacemaker

1

0

High-throughput

0.518

High

171115

CBPC1
Cytosolic carboxypeptidase 1

1

0

High-throughput

0.518

High

171116

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

0

High-throughput

0.518

High

171072

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.515

High

171079

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

171082

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.513

High

171096

STMN2
Stathmin-2

1

0

High-throughput

0.513

High

171105

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.513

High

171049

EPHB6
Ephrin type-B receptor 6

1

2

High-throughput

0.494

High

171059

RPGP1
Rap1 GTPase-activating protein 1

1

2

High-throughput

0.494

High

171066

KIF1A
Kinesin-like protein KIF1A

1

3

High-throughput

0.494

High

171077

RHG21
Rho GTPase-activating protein 21

1

1

High-throughput

0.494

High

171078

RPGP2
Rap1 GTPase-activating protein 2

1

2

High-throughput

0.494

High

171085

KI21A
Kinesin-like protein KIF21A

1

3

High-throughput

0.494

High

171071

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.486

High

171060

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

171050

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

171053

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

171056

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

171100

MAML3
Mastermind-like protein 3

1

0

High-throughput

0.460

High

171057

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

171058

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

171061

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.437

High

171091

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.437

High

171107

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

171094

DEN10
DENN domain-containing protein 10

4

0

High-throughput

0.358

High

171088

COMD2
COMM domain-containing protein 2

3

0

High-throughput

0.345

High

171110

COMD8
COMM domain-containing protein 8

3

0

High-throughput

0.345

High

171068

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

71501

MEI4
Meiosis-specific protein MEI4

2

0

High-throughput

0.316

High

171067

CBLB
E3 ubiquitin-protein ligase CBL-B

2

0

High-throughput

0.316

High

171073

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

0

High-throughput

0.316

High

171076

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

2

0

High-throughput

0.316

High

171099

RB39B
Ras-related protein Rab-39B

2

0

High-throughput

0.316

High

171101

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.316

High

171109

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

2

0

High-throughput

0.316

High

171087

COMD7
COMM domain-containing protein 7

2

0

High-throughput

0.313

High

171112

COMD9
COMM domain-containing protein 9

2

0

High-throughput

0.313

High

171047

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.282

High

171063

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.282

High

171064

U2AF1
Splicing factor U2AF 35 kDa subunit

1

0

High-throughput

0.282

High

171069

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.282

High

171070

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.282

High

171086

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.282

High

171095

NRCAM
Neuronal cell adhesion molecule

1

0

High-throughput

0.282

High

171098

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.282

High

171102

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.282

High

171117

TPPC1
Trafficking protein particle complex subunit 1

1

0

High-throughput

0.282

High

171093

O13G1
Olfactory receptor 13G1

1

0

High-throughput

0.279

Low

171097

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025