Protein: BIEA
Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase)

Gene: BIEA, BLVRA
Organism: Homo sapiens
Interactions: 89
UniProt ID: P53004

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0004074 - biliverdin reductase [NAD(P)H] activity
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0042167 - heme catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

318196

DDHD2
Triacylglycerol hydrolase DDHD2

3

1

High-throughput

0.667

High

916210

TLN1
Talin-1

3

2

High-throughput

0.667

High

916155

BIEA
Biliverdin reductase A

1

8

Small-scale

0.647

High

916170

RRAGB
Ras-related GTP-binding protein B

3

0

High-throughput

0.638

High

916187

RT4I1
NAD(P)H oxidoreductase RTN4IP1, mitochondrial

3

0

High-throughput

0.638

High

916194

OSBL6
Oxysterol-binding protein-related protein 6

3

0

High-throughput

0.638

High

916207

PCYOX
Prenylcysteine oxidase 1

3

0

High-throughput

0.638

High

916184

LNX1
E3 ubiquitin-protein ligase LNX

3

0

High-throughput

0.636

High

916161

KPCZ
Protein kinase C zeta type

1

3

Small-scale

0.604

High

916211

SNX5
Sorting nexin-5

2

0

High-throughput

0.585

High

461299

HS90A
Heat shock protein HSP 90-alpha

2

1

High-throughput

0.584

High

728126

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.578

High

436634

KPCB
Protein kinase C beta type

1

3

Small-scale

0.536

High

728564

AKT2
RAC-beta serine/threonine-protein kinase

1

3

Small-scale

0.536

High

258813

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.536

High

274509

DNJB6
DnaJ homolog subfamily B member 6

1

3

High-throughput

0.536

High

679109

DNJB1
DnaJ homolog subfamily B member 1

1

2

High-throughput

0.536

High

916168

TBB8
Tubulin beta-8 chain

1

3

High-throughput

0.536

High

602767

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

916176

CARM1
Histone-arginine methyltransferase CARM1

1

0

High-throughput

0.513

High

916177

PHF13
PHD finger protein 13

1

0

High-throughput

0.513

High

916179

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

916182

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.513

High

691685

MK03
Mitogen-activated protein kinase 3

1

1

Small-scale

0.501

High

703510

MK01
Mitogen-activated protein kinase 1

1

1

Small-scale

0.500

High

916160

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

2

Small-scale

0.500

High

916178

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.489

High

916188

EZH1
Histone-lysine N-methyltransferase EZH1

1

1

High-throughput

0.489

High

241170

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

536807

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

916162

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

916163

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

916172

TBA1A
Tubulin alpha-1A chain

1

4

High-throughput

0.479

High

916173

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.479

High

916190

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

916196

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

916200

RHOF
Rho-related GTP-binding protein RhoF

1

3

High-throughput

0.479

High

345556

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

348432

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

507711

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

695003

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

878820

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

916157

RHOA
Transforming protein RhoA

1

0

High-throughput

0.458

High

916158

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

916159

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.458

High

916171

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

916174

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

916183

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

916193

RNF26
E3 ubiquitin-protein ligase RNF26

1

0

High-throughput

0.458

High

916197

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

916203

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

916206

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

711856

LTK
Leukocyte tyrosine kinase receptor

1

2

High-throughput

0.457

High

916156

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

411633

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

703920

DUS1
Dual specificity protein phosphatase 1

1

1

High-throughput

0.437

High

916165

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

916185

DUS19
Dual specificity protein phosphatase 19

1

1

High-throughput

0.437

High

916191

RHOV
Rho-related GTP-binding protein RhoV

1

5

High-throughput

0.437

High

404741

PRIO
Major prion protein

1

0

High-throughput

0.426

High

563462

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

916201

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

916209

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

888443

TSP3
Thrombospondin-3

3

0

High-throughput

0.347

High

916208

TBX20
T-box transcription factor TBX20

3

0

High-throughput

0.347

High

916175

WDR53
WD repeat-containing protein 53

2

0

High-throughput

0.328

High

916189

DNSL2
Deoxyribonuclease-1-like 2

2

0

High-throughput

0.328

High

916198

P2Y12
P2Y purinoceptor 12

2

0

High-throughput

0.328

High

259670

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.318

High

907771

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.279

Low

916169

ANR39
Ankyrin repeat domain-containing protein 39

1

0

High-throughput

0.279

Low

916180

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.279

Low

916181

CIART
Circadian-associated transcriptional repressor

1

0

High-throughput

0.279

Low

916192

ODC
Mitochondrial 2-oxodicarboxylate carrier

1

0

High-throughput

0.279

Low

916204

ASIC5
Bile acid-sensitive ion channel

1

0

High-throughput

0.279

Low

916205

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.279

Low

105622

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

371541

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

588276

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

767767

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

916164

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.249

Low

916166

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

916199

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

916202

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

330087

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

916167

TPD53
Tumor protein D53

1

0

High-throughput

0.232

Low

916186

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

916195

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025