Protein: SEN54
tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)

Gene: SEN54, TSEN54
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q7Z6J9

Gene Ontology (top 5):
GO:0000214 - tRNA-intron endonuclease complex
GO:0000379 - tRNA-type intron splice site recognition and cleavage
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1280116

SEN2
tRNA-splicing endonuclease subunit Sen2

7

0

Small-scale

0.717

High

1280121

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

5

0

Small-scale

0.683

High

1280120

SEN15
tRNA-splicing endonuclease subunit Sen15

4

0

Small-scale

0.661

High

1280131

AMMR1
Nuclear protein AMMECR1

3

0

High-throughput

0.638

High

681853

RBTN2
Rhombotin-2

2

2

High-throughput

0.606

High

179062

IMA6
Importin subunit alpha-6

2

0

High-throughput

0.580

High

833648

NAA10
N-alpha-acetyltransferase 10

2

0

High-throughput

0.580

High

1145813

IRF4
Interferon regulatory factor 4

2

0

High-throughput

0.580

High

1280128

SPN90
NCK-interacting protein with SH3 domain

2

0

High-throughput

0.580

High

1280122

LHX4
LIM/homeobox protein Lhx4

2

1

High-throughput

0.553

High

1280129

LHX3
LIM/homeobox protein Lhx3

2

1

High-throughput

0.553

High

995109

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

799248

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.481

High

1280118

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

1113544

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1280125

SEN34
tRNA-splicing endonuclease subunit Sen34

1

0

Small-scale

0.458

High

1280126

THUM3
tRNA

1

0

High-throughput

0.426

High

65084

GG6L9
Golgin subfamily A member 6-like protein 9

2

0

High-throughput

0.316

High

783309

TRI23
E3 ubiquitin-protein ligase TRIM23

2

0

High-throughput

0.316

High

1146006

K1H1
Keratin, type I cuticular Ha1

2

0

High-throughput

0.316

High

1179970

CCD57
Coiled-coil domain-containing protein 57

2

0

High-throughput

0.316

High

1238534

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.316

High

1280115

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

0

High-throughput

0.316

High

1280119

IKBD
NF-kappa-B inhibitor delta

2

0

High-throughput

0.316

High

1280124

RM38
Large ribosomal subunit protein mL38

2

0

High-throughput

0.316

High

1280127

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

1009234

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

1280123

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

293932

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1196829

TM119
Transmembrane protein 119

1

0

High-throughput

0.249

Low

1280117

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

1

0

High-throughput

0.249

Low

1280130

XPO7
Exportin-7

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025