Protein: SPN90
NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)

Gene: SPN90, NCKIPSD
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q9NZQ3

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0005886 - plasma membrane
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987988

GRB2
Growth factor receptor-bound protein 2

6

5

Small-scale

0.957

High

222219

NCK2
Cytoplasmic protein NCK2

6

5

High-throughput

0.950

High

1453535

BAIP2
BAR/IMD domain-containing adapter protein 2

4

3

Small-scale

0.905

High

594119

NCK1
SH2/SH3 adapter protein NCK1

3

5

Small-scale

0.882

High

1121990

ARHG7
Rho guanine nucleotide exchange factor 7

3

3

High-throughput

0.855

High

1154183

ITSN1
Intersectin-1

3

4

High-throughput

0.855

High

1453435

ITSN2
Intersectin-2

3

3

High-throughput

0.855

High

1453536

GIT1
ARF GTPase-activating protein GIT1

3

1

High-throughput

0.855

High

1404631

STAC
SH3 and cysteine-rich domain-containing protein

3

7

High-throughput

0.853

High

1122454

GIT2
ARF GTPase-activating protein GIT2

2

2

High-throughput

0.811

High

1140203

ARHG6
Rho guanine nucleotide exchange factor 6

2

3

High-throughput

0.811

High

1452507

ABI2
Abl interactor 2

2

6

High-throughput

0.783

High

619120

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

0

High-throughput

0.770

High

1416778

RFIP5
Rab11 family-interacting protein 5

2

0

High-throughput

0.770

High

440759

FYN
Tyrosine-protein kinase Fyn

2

1

High-throughput

0.743

High

1390827

CPNE2
Copine-2

2

0

High-throughput

0.742

High

250352

VINEX
Vinexin

1

5

High-throughput

0.740

High

855784

CRK
Adapter molecule crk

2

8

High-throughput

0.737

High

1417973

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.698

High

167131

GEMI2
Gem-associated protein 2

4

0

High-throughput

0.667

High

1360308

GEMI6
Gem-associated protein 6

4

0

High-throughput

0.667

High

966954

1433G
14-3-3 protein gamma

3

5

High-throughput

0.667

High

877024

KC1A
Casein kinase I isoform alpha

3

1

High-throughput

0.662

High

1292589

FCSD1
F-BAR and double SH3 domains protein 1

3

4

High-throughput

0.662

High

1357700

SNX33
Sorting nexin-33

3

2

High-throughput

0.662

High

1403295

RBM15
RNA-binding protein 15

3

1

High-throughput

0.662

High

1453528

EP15R
Epidermal growth factor receptor substrate 15-like 1

3

2

High-throughput

0.662

High

1451585

GEMI8
Gem-associated protein 8

4

0

High-throughput

0.661

High

920515

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.656

High

1360096

PALLD
Palladin

3

0

Small-scale

0.638

High

258396

GAS7
Growth arrest-specific protein 7

4

2

High-throughput

0.638

High

990804

1433Z
14-3-3 protein zeta/delta

2

5

High-throughput

0.628

High

1336763

RB15B
Putative RNA-binding protein 15B

2

1

High-throughput

0.628

High

362390

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.618

High

728452

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.614

High

138944

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

2

0

High-throughput

0.602

High

336140

ZFYV9
Zinc finger FYVE domain-containing protein 9

2

0

High-throughput

0.602

High

972073

1433E
14-3-3 protein epsilon

2

0

High-throughput

0.602

High

1453531

DACH1
Dachshund homolog 1

2

0

High-throughput

0.602

High

128483

PSMD9
26S proteasome non-ATPase regulatory subunit 9

2

0

High-throughput

0.601

High

157934

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.586

High

1447367

ANLN
Anillin

1

0

High-throughput

0.586

High

1160603

SMN
Survival motor neuron protein

2

0

High-throughput

0.585

High

1453530

DDX20
Probable ATP-dependent RNA helicase DDX20

2

0

High-throughput

0.585

High

480332

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.580

High

940793

LEG4
Galectin-4

2

0

High-throughput

0.580

High

1109409

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

High-throughput

0.580

High

1120706

VEZF1
Vascular endothelial zinc finger 1

2

0

High-throughput

0.580

High

1259289

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.580

High

1280128

SEN54
tRNA-splicing endonuclease subunit Sen54

2

0

High-throughput

0.580

High

1359941

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.580

High

1401148

RET7
Retinoid-binding protein 7

2

0

High-throughput

0.580

High

1408348

PKP2
Plakophilin-2

2

0

High-throughput

0.580

High

1414282

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.580

High

1430127

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

1451075

RBM22
Pre-mRNA-splicing factor RBM22

2

0

High-throughput

0.580

High

964760

DCAF7
DDB1- and CUL4-associated factor 7

2

0

High-throughput

0.576

High

855947

CRKL
Crk-like protein

1

7

High-throughput

0.575

High

1449461

DIAP3
Protein diaphanous homolog 3

1

0

Small-scale

0.549

High

691487

1433T
14-3-3 protein theta

1

5

High-throughput

0.536

High

730297

1433B
14-3-3 protein beta/alpha

1

5

High-throughput

0.536

High

863007

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.536

High

958364

ARP2
Actin-related protein 2

1

2

High-throughput

0.536

High

1049844

1433F
14-3-3 protein eta

1

5

High-throughput

0.536

High

1111986

SNX1
Sorting nexin-1

1

1

High-throughput

0.536

High

1124743

SRC8
Src substrate cortactin

1

7

High-throughput

0.536

High

1453533

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

4

High-throughput

0.536

High

944581

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.530

High

415906

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

1449178

CLTR2
Cysteinyl leukotriene receptor 2

1

0

High-throughput

0.518

High

1449340

RL3R1
Relaxin-3 receptor 1

1

0

High-throughput

0.518

High

342050

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

430443

JUN
Transcription factor Jun

1

0

High-throughput

0.513

High

442498

GELS
Gelsolin

1

0

High-throughput

0.513

High

625673

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

866847

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

993359

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.513

High

1040392

DYST
Dystonin

1

0

High-throughput

0.513

High

1212474

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.513

High

1307940

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.513

High

1353058

GEMI5
Gem-associated protein 5

1

0

High-throughput

0.513

High

1402678

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.513

High

1436077

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

1453534

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.513

High

1453526

ARP3B
Actin-related protein 3B

1

2

High-throughput

0.489

High

869524

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

Small-scale

0.480

High

173479

XPO1
Exportin-1

1

0

High-throughput

0.458

High

646955

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

988771

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

Small-scale

0.458

High

1140957

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1255868

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1322802

CNTRB
Centrobin

1

0

High-throughput

0.458

High

1367448

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1368160

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1290499

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

1

High-throughput

0.445

High

1155397

RB11B
Ras-related protein Rab-11B

1

0

High-throughput

0.426

High

1156954

CNGA3
Cyclic nucleotide-gated channel alpha-3

1

0

High-throughput

0.426

High

1258598

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.426

High

1363346

DDX1
ATP-dependent RNA helicase DDX1

1

0

High-throughput

0.426

High

1367886

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

0

High-throughput

0.426

High

1370416

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.426

High

1409695

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

0

High-throughput

0.426

High

1451492

GID8
Glucose-induced degradation protein 8 homolog

1

0

High-throughput

0.426

High

1330305

KC1AL
Casein kinase I isoform alpha-like

1

2

High-throughput

0.407

High

1059984

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

Small-scale

0.391

High

1411517

PDD2L
Programmed cell death protein 2-like

2

0

High-throughput

0.328

High

1450423

FBX28
F-box only protein 28

2

0

High-throughput

0.328

High

1198863

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

1309213

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

1453529

ZBT47
Zinc finger and BTB domain-containing protein 47

2

0

High-throughput

0.316

High

1453532

PS1C2
Psoriasis susceptibility 1 candidate gene 2 protein

2

0

High-throughput

0.316

High

106760

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

1397929

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

0

High-throughput

0.251

Low

1164605

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

1258200

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.249

Low

1438056

RC3H2
Roquin-2

1

0

High-throughput

0.249

Low

1453527

JCAD
Junctional cadherin 5-associated protein

1

0

High-throughput

0.249

Low

888681

YLPM1
YLP motif-containing protein 1

1

0

High-throughput

0.232

Low

1399945

FACOS
FANCD2 opposite strand protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025