Protein: SEN15
tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)

Gene: SEN15, TSEN15
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q8WW01

Gene Ontology (top 5):
GO:0003676 - nucleic acid binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 - mRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1335480

SEN2
tRNA-splicing endonuclease subunit Sen2

4

0

Small-scale

0.846

High

1358904

SEN34
tRNA-splicing endonuclease subunit Sen34

4

0

Small-scale

0.846

High

1280120

SEN54
tRNA-splicing endonuclease subunit Sen54

4

0

Small-scale

0.661

High

1358895

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

4

0

Small-scale

0.661

High

610418

PRS6A
26S proteasome regulatory subunit 6A

3

0

High-throughput

0.638

High

1358896

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

0

High-throughput

0.634

High

1358909

MOG1
Ran guanine nucleotide release factor

3

0

High-throughput

0.634

High

681885

RBTN2
Rhombotin-2

2

1

High-throughput

0.606

High

1358918

IKZF3
Zinc finger protein Aiolos

2

1

High-throughput

0.606

High

269320

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

976120

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.580

High

1044686

ARI5A
AT-rich interactive domain-containing protein 5A

2

0

High-throughput

0.580

High

1048937

REL
Proto-oncogene c-Rel

2

0

High-throughput

0.580

High

1081419

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1212429

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

2

0

High-throughput

0.580

High

1218942

TASO2
Protein TASOR 2

2

0

High-throughput

0.580

High

1287346

ZN554
Zinc finger protein 554

2

0

High-throughput

0.580

High

1358900

ZMAT2
Zinc finger matrin-type protein 2

2

0

High-throughput

0.580

High

410965

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

0

High-throughput

0.551

High

1358916

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.513

High

1358910

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.486

High

965494

LMO4
LIM domain transcription factor LMO4

1

1

High-throughput

0.464

High

332426

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

0

High-throughput

0.426

High

1326420

MINK1
Misshapen-like kinase 1

2

0

High-throughput

0.328

High

71518

MEI4
Meiosis-specific protein MEI4

2

0

High-throughput

0.316

High

1007963

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.316

High

1061792

TLE5
TLE family member 5

2

0

High-throughput

0.316

High

1240627

PLB1
Phospholipase B1, membrane-associated

2

0

High-throughput

0.316

High

1253066

ZN620
Zinc finger protein 620

2

0

High-throughput

0.316

High

1258152

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

1349623

PHOP2
Pyridoxal phosphate phosphatase PHOSPHO2

2

0

High-throughput

0.316

High

1350335

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.316

High

1358894

ASB12
Ankyrin repeat and SOCS box protein 12

2

0

High-throughput

0.316

High

1358897

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1358899

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.316

High

1358901

TSSK2
Testis-specific serine/threonine-protein kinase 2

2

0

High-throughput

0.316

High

1358902

AIF1L
Allograft inflammatory factor 1-like

2

0

High-throughput

0.316

High

1358905

PBX4
Pre-B-cell leukemia transcription factor 4

2

0

High-throughput

0.316

High

1358907

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1358908

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.316

High

1358911

DAAF6
Dynein axonemal assembly factor 6

2

0

High-throughput

0.316

High

1358913

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

2

0

High-throughput

0.313

High

1358906

NBPF3
NBPF family member NBPF3

1

0

High-throughput

0.282

High

219204

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.279

Low

465854

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.279

Low

472195

TRFM
Melanotransferrin

1

0

High-throughput

0.279

Low

482259

PAEP
Glycodelin

1

0

High-throughput

0.279

Low

947479

RAB15
Ras-related protein Rab-15

1

0

High-throughput

0.279

Low

1009266

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

1042037

LMNB2
Lamin-B2

1

0

High-throughput

0.279

Low

1358898

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

1358903

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.279

Low

1358912

TULP4
Tubby-related protein 4

1

0

High-throughput

0.279

Low

1358914

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1

0

High-throughput

0.279

Low

1358915

KLH14
Kelch-like protein 14

1

0

High-throughput

0.279

Low

1358917

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

1

0

High-throughput

0.279

Low

1358919

ZN215
Zinc finger protein 215

1

0

High-throughput

0.279

Low

1328371

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

472332

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

1148865

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

0

High-throughput

0.232

Low

1358920

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025