Protein: HMBX1
Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1)

Gene: HMBX1, HMBOX1
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q6NT76

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0003691 - double-stranded telomeric DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1238082

HMBX1
Homeobox-containing protein 1

3

13

High-throughput

0.861

High

192379

GSC2
Homeobox protein goosecoid-2

2

19

High-throughput

0.783

High

685232

PAX6
Paired box protein Pax-6

2

17

High-throughput

0.783

High

893703

MEOX1
Homeobox protein MOX-1

2

20

High-throughput

0.783

High

1210142

VAX1
Ventral anterior homeobox 1

2

19

High-throughput

0.783

High

1238101

DYL2
Dynein light chain 2, cytoplasmic

4

2

High-throughput

0.697

High

1238120

ASB7
Ankyrin repeat and SOCS box protein 7

5

0

High-throughput

0.694

High

549332

SRF
Serum response factor

1

4

High-throughput

0.691

High

991576

DYL1
Dynein light chain 1, cytoplasmic

4

2

High-throughput

0.689

High

935534

MFAP1
Microfibrillar-associated protein 1

3

1

High-throughput

0.675

High

1238083

AEBP2
Zinc finger protein AEBP2

3

13

High-throughput

0.675

High

1238094

ZN417
Zinc finger protein 417

3

1

High-throughput

0.675

High

1238099

KAT5
Histone acetyltransferase KAT5

3

1

High-throughput

0.675

High

1238121

SH24A
SH2 domain-containing protein 4A

3

6

High-throughput

0.675

High

1238127

CBX8
Chromobox protein homolog 8

3

2

High-throughput

0.675

High

1238137

ZN581
Zinc finger protein 581

3

6

High-throughput

0.675

High

1238139

MO4L1
Mortality factor 4-like protein 1

3

1

High-throughput

0.675

High

624511

WT1
Wilms tumor protein

3

4

High-throughput

0.667

High

1232410

Q6FHY5
MEOX2 protein

1

20

High-throughput

0.665

High

749059

RL9
Large ribosomal subunit protein uL6

3

0

High-throughput

0.646

High

1118890

BYST
Bystin

3

0

High-throughput

0.646

High

1185255

F161A
Protein FAM161A

3

0

High-throughput

0.646

High

1238134

ABITM
Protein Abitram

3

0

High-throughput

0.646

High

1052878

HME1
Homeobox protein engrailed-1

1

20

High-throughput

0.646

High

1238144

MEMO1
Protein MEMO1

3

0

High-throughput

0.638

High

1238111

SCNM1
Sodium channel modifier 1

3

0

High-throughput

0.622

High

893945

MEOX2
Homeobox protein MOX-2

1

20

High-throughput

0.621

High

132487

CDC7
Cell division cycle 7-related protein kinase

2

5

High-throughput

0.606

High

297825

PIAS2
E3 SUMO-protein ligase PIAS2

2

1

High-throughput

0.606

High

318139

IPO13
Importin-13

2

6

High-throughput

0.606

High

342219

BRD1
Bromodomain-containing protein 1

2

13

High-throughput

0.606

High

585056

ZN250
Zinc finger protein 250

2

2

High-throughput

0.606

High

682043

RBTN1
Rhombotin-1

2

7

High-throughput

0.606

High

685612

U2AF2
Splicing factor U2AF 65 kDa subunit

2

1

High-throughput

0.606

High

1037723

PAX5
Paired box protein Pax-5

2

17

High-throughput

0.606

High

1057624

CDK18
Cyclin-dependent kinase 18

2

10

High-throughput

0.606

High

1136796

MO4L2
Mortality factor 4-like protein 2

2

1

High-throughput

0.606

High

1150110

TCEA2
Transcription elongation factor A protein 2

2

1

High-throughput

0.606

High

1228869

ZFY26
Zinc finger FYVE domain-containing protein 26

2

4

High-throughput

0.606

High

1238092

GA2L2
GAS2-like protein 2

2

3

High-throughput

0.606

High

1238093

LMO3
LIM domain only protein 3

2

7

High-throughput

0.606

High

1238100

MCRS1
Microspherule protein 1

2

1

High-throughput

0.606

High

1238117

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

2

5

High-throughput

0.606

High

1238128

ZBT26
Zinc finger and BTB domain-containing protein 26

2

3

High-throughput

0.606

High

1238130

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

1238138

RCOR3
REST corepressor 3

2

16

High-throughput

0.606

High

1238141

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

2

20

High-throughput

0.606

High

1238142

ZMYM5
Zinc finger MYM-type protein 5

2

6

High-throughput

0.606

High

140314

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

982973

RS25
Small ribosomal subunit protein eS25

2

0

High-throughput

0.580

High

1111048

SNW1
SNW domain-containing protein 1

2

0

High-throughput

0.580

High

1200123

BOREA
Borealin

2

0

High-throughput

0.580

High

1214341

SYT6
Synaptotagmin-6

2

0

High-throughput

0.580

High

1238087

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.580

High

1238098

FGF11
Fibroblast growth factor 11

2

0

High-throughput

0.580

High

1238107

PRP18
Pre-mRNA-splicing factor 18

2

0

High-throughput

0.580

High

1238115

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1238116

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

1238126

KIF9
Kinesin-like protein KIF9

2

0

High-throughput

0.580

High

1238131

F217B
Protein FAM217B

2

0

High-throughput

0.580

High

1238132

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

2

0

High-throughput

0.580

High

1238140

DPOLL
DNA polymerase lambda

2

0

High-throughput

0.580

High

67169

ZAR1L
Protein ZAR1-like

2

0

High-throughput

0.576

High

48363

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

3

High-throughput

0.573

High

208856

ZBT24
Zinc finger and BTB domain-containing protein 24

1

4

High-throughput

0.573

High

286379

DAB1
Disabled homolog 1

1

2

High-throughput

0.573

High

334423

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.573

High

471864

RU2B
U2 small nuclear ribonucleoprotein B''

1

1

High-throughput

0.573

High

869894

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.573

High

900377

FXR2
RNA-binding protein FXR2

1

1

High-throughput

0.573

High

909285

CCNG1
Cyclin-G1

1

4

High-throughput

0.573

High

930727

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

3

High-throughput

0.573

High

1006144

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

1

High-throughput

0.573

High

1095393

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

3

High-throughput

0.573

High

1238090

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

1

1

High-throughput

0.573

High

1238104

FRMD6
FERM domain-containing protein 6

1

3

High-throughput

0.573

High

1238106

ZN587
Zinc finger protein 587

1

1

High-throughput

0.573

High

1238118

MAGH1
Melanoma-associated antigen H1

1

1

High-throughput

0.573

High

1238119

CARD9
Caspase recruitment domain-containing protein 9

1

2

High-throughput

0.573

High

1238146

ZN337
Zinc finger protein 337

1

1

High-throughput

0.573

High

385855

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

6

High-throughput

0.571

High

1094033

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.549

High

1155295

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

0

High-throughput

0.549

High

1238085

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

0

High-throughput

0.549

High

1238095

LNX1
E3 ubiquitin-protein ligase LNX

1

0

High-throughput

0.549

High

1238102

REEP6
Receptor expression-enhancing protein 6

1

0

High-throughput

0.549

High

1238103

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.549

High

1238123

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

0

High-throughput

0.549

High

1238125

SP30L
Histone deacetylase complex subunit SAP30L

1

0

High-throughput

0.549

High

166163

AIM2
Interferon-inducible protein AIM2

1

2

High-throughput

0.536

High

682518

S100P
Protein S100-P

1

4

High-throughput

0.536

High

1056791

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.536

High

1115732

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.536

High

1235444

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.536

High

1238097

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.536

High

1181245

Q32MN6
TBP protein

1

5

High-throughput

0.515

High

1238109

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.513

High

1238143

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

422336

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

257885

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

Small-scale

0.500

High

558207

XRCC6
X-ray repair cross-complementing protein 6

1

8

Small-scale

0.500

High

505726

ZN688
Zinc finger protein 688

1

5

High-throughput

0.481

High

628807

TBP
TATA-box-binding protein

1

5

High-throughput

0.481

High

993619

UBC9
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.481

High

1238113

PDIP3
Polymerase delta-interacting protein 3

1

3

High-throughput

0.481

High

143055

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

474064

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

655236

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

High-throughput

0.479

High

764836

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

775862

HNF1B
Hepatocyte nuclear factor 1-beta

1

15

High-throughput

0.479

High

799214

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

979836

H4
Histone H4

1

3

High-throughput

0.479

High

1068839

IFFO1
Non-homologous end joining factor IFFO1

1

7

High-throughput

0.479

High

1087807

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1088400

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

12

High-throughput

0.479

High

1088878

TP53B
TP53-binding protein 1

1

4

High-throughput

0.479

High

1129627

MDC1
Mediator of DNA damage checkpoint protein 1

1

17

High-throughput

0.479

High

1238088

AMOL1
Angiomotin-like protein 1

1

4

High-throughput

0.479

High

1238105

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

46761

A0A384ME17
Elongation factor Tu

1

1

High-throughput

0.470

High

50058

A1A5B0
ANKRD36 protein

1

2

High-throughput

0.470

High

1238084

Q7KZS0
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.470

High

1238096

Q8WUT1
POLDIP3 protein

1

2

High-throughput

0.470

High

1238112

CDAC1
Cytidine and dCMP deaminase domain-containing protein 1

1

0

High-throughput

0.458

High

559391

XRCC5
X-ray repair cross-complementing protein 5

1

8

Small-scale

0.445

High

799938

COIL
Coilin

1

1

Small-scale

0.445

High

1238124

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.445

High

1238129

NOP10
H/ACA ribonucleoprotein complex subunit 3

1

1

Small-scale

0.445

High

1238133

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

3

Small-scale

0.445

High

1238135

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

Small-scale

0.445

High

1238136

GRHL1
Grainyhead-like protein 1 homolog

1

5

High-throughput

0.445

High

67247

AN36A
Ankyrin repeat domain-containing protein 36A

1

2

High-throughput

0.439

High

882728

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.439

High

1200457

COBL1
Cordon-bleu protein-like 1

1

16

High-throughput

0.437

High

516536

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

3546

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

6

High-throughput

0.417

High

1238122

CH033
UPF0488 protein C8orf33

3

0

High-throughput

0.352

High

1187640

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

1238086

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1238089

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

1238091

FA13C
Protein FAM13C

1

0

High-throughput

0.299

High

1238110

FND11
Fibronectin type III domain-containing protein 11

1

0

High-throughput

0.299

High

1238145

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.299

High

1238147

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.282

High

96987

NPIA7
Nuclear pore complex-interacting protein family member A7

1

0

High-throughput

0.268

Low

1238108

SELS
Selenoprotein S

1

0

High-throughput

0.249

Low

1238114

F117A
Protein FAM117A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025