Protein: PTPRS
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)

Gene: PTPRS
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q13332

Gene Ontology (top 5):
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006470 - protein dephosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1031989

NTRK3
NT-3 growth factor receptor

4

20

Small-scale

0.899

High

352604

TNFA
Tumor necrosis factor

3

2

High-throughput

0.861

High

588768

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

1

High-throughput

0.861

High

739965

TGFR2
TGF-beta receptor type-2

3

3

High-throughput

0.861

High

1025279

LIPA1
Liprin-alpha-1

3

11

Small-scale

0.845

High

1031984

I13R2
Interleukin-13 receptor subunit alpha-2

2

19

High-throughput

0.811

High

616971

PTPRD
Receptor-type tyrosine-protein phosphatase delta

2

17

Small-scale

0.800

High

713797

RYK
Tyrosine-protein kinase RYK

2

20

Small-scale

0.789

High

68228

HECA2
HEPACAM family member 2

3

16

High-throughput

0.770

High

1031992

CEA21
Carcinoembryonic antigen-related cell adhesion molecule 21

3

16

High-throughput

0.770

High

702343

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

0

High-throughput

0.770

High

1031991

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

17

Small-scale

0.740

High

59752

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

9

High-throughput

0.726

High

879392

FCGRN
IgG receptor FcRn large subunit p51

2

5

High-throughput

0.726

High

1032016

LRIQ1
Leucine-rich repeat and IQ domain-containing protein 1

2

4

High-throughput

0.726

High

265768

CRLF1
Cytokine receptor-like factor 1

1

20

High-throughput

0.691

High

452411

PGFRB
Platelet-derived growth factor receptor beta

1

15

High-throughput

0.691

High

560060

CTLA4
Cytotoxic T-lymphocyte protein 4

1

3

High-throughput

0.691

High

616916

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

20

High-throughput

0.691

High

685236

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

13

High-throughput

0.691

High

943113

KC1G2
Casein kinase I isoform gamma-2

1

3

High-throughput

0.691

High

439270

MMP3
Stromelysin-1

3

1

High-throughput

0.667

High

617791

OMGP
Oligodendrocyte-myelin glycoprotein

1

6

Small-scale

0.647

High

1032018

SLIK1
SLIT and NTRK-like protein 1

1

3

Small-scale

0.647

High

500785

CLUS
Clusterin

2

2

High-throughput

0.628

High

1031997

S39A5
Zinc transporter ZIP5

2

2

High-throughput

0.628

High

1032013

ARRD3
Arrestin domain-containing protein 3

2

4

High-throughput

0.628

High

1032014

MRAP2
Melanocortin-2 receptor accessory protein 2

2

2

High-throughput

0.628

High

1032033

PCD12
Protocadherin-12

2

17

High-throughput

0.628

High

1032046

PCDGD
Protocadherin gamma-B1

2

16

High-throughput

0.628

High

255244

LIPA3
Liprin-alpha-3

1

11

Small-scale

0.621

High

259643

LIPA2
Liprin-alpha-2

1

13

Small-scale

0.621

High

1032041

OPT
Opticin

1

8

High-throughput

0.618

High

279860

TRIO
Triple functional domain protein

1

2

High-throughput

0.618

High

384777

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

436285

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

489957

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

17

High-throughput

0.618

High

564508

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

793298

MUC18
Cell surface glycoprotein MUC18

1

16

High-throughput

0.618

High

852459

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

892348

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

893964

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

900436

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

915648

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

925247

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

957574

PKD1
Polycystin-1

1

5

Small-scale

0.618

High

1031988

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1031999

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1032029

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1032030

TM231
Transmembrane protein 231

3

1

High-throughput

0.609

High

1032049

LIPG
Endothelial lipase

2

0

High-throughput

0.602

High

1031987

RAB35
Ras-related protein Rab-35

1

5

High-throughput

0.590

High

1031986

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.584

High

353032

EPO
Erythropoietin

1

0

High-throughput

0.578

High

507980

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.575

High

1031979

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.575

High

1032031

MANS1
MANSC domain-containing protein 1

2

1

High-throughput

0.574

High

266552

GPC4
Glypican-4

1

8

Small-scale

0.561

High

1032005

RN149
E3 ubiquitin-protein ligase RNF149

2

8

High-throughput

0.558

High

1032001

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

5

Small-scale

0.553

High

1032009

CSKI2
Caskin-2

1

7

High-throughput

0.553

High

1031977

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

17

Small-scale

0.545

High

597387

PTN
Pleiotrophin

1

3

High-throughput

0.541

High

644028

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.541

High

1031980

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.541

High

1032002

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.541

High

132258

DLL1
Delta-like protein 1

1

3

High-throughput

0.536

High

259206

CAD16
Cadherin-16

1

20

High-throughput

0.536

High

269415

STX11
Syntaxin-11

1

3

High-throughput

0.536

High

566025

INAR1
Interferon alpha/beta receptor 1

1

18

High-throughput

0.536

High

1031993

CC50B
Cell cycle control protein 50B

1

2

High-throughput

0.536

High

1031996

I20RB
Interleukin-20 receptor subunit beta

1

4

High-throughput

0.536

High

1032003

NRSN1
Neurensin-1

1

1

High-throughput

0.536

High

1032006

ARRD4
Arrestin domain-containing protein 4

1

4

High-throughput

0.536

High

1032007

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

7

High-throughput

0.536

High

1032023

SYT11
Synaptotagmin-11

1

1

High-throughput

0.536

High

1032026

TMPSD
Transmembrane protease serine 13

1

8

High-throughput

0.536

High

1032038

GPC5B
G-protein coupled receptor family C group 5 member B

1

1

High-throughput

0.536

High

1032042

FBX2
F-box only protein 2

1

9

High-throughput

0.536

High

1032043

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

6

High-throughput

0.536

High

1032047

PCDG7
Protocadherin gamma-A7

1

17

High-throughput

0.536

High

1032050

ST14
Suppressor of tumorigenicity 14 protein

1

7

High-throughput

0.536

High

1032052

PTC2
Protein patched homolog 2

1

1

High-throughput

0.536

High

1032053

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

714961

PROF2
Profilin-2

1

0

High-throughput

0.518

High

1031978

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

1032011

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.518

High

1032022

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.518

High

1032024

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.518

High

1031983

IF4A2
Eukaryotic initiation factor 4A-II

1

2

High-throughput

0.515

High

486256

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.513

High

1032025

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

849041

GPC3
Glypican-3

1

8

Small-scale

0.501

High

1032004

GPC2
Glypican-2 [Cleaved into: Secreted glypican-2]

1

8

Small-scale

0.501

High

1032051

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

8

Small-scale

0.501

High

902564

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.494

High

621320

PRPH2
Peripherin-2

1

6

High-throughput

0.489

High

1030780

SG2A2
Mammaglobin-A

1

1

High-throughput

0.489

High

1031990

SGCA
Alpha-sarcoglycan

1

2

High-throughput

0.489

High

1032008

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

1

High-throughput

0.489

High

1032027

SE6L1
Seizure 6-like protein

1

5

High-throughput

0.489

High

1032028

CSTL1
Cystatin-like 1

1

3

High-throughput

0.489

High

1032032

UD17
UDP-glucuronosyltransferase 1A7

1

1

High-throughput

0.489

High

123584

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

205357

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

311536

SMC2
Structural maintenance of chromosomes protein 2

1

2

High-throughput

0.479

High

521907

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

1031982

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

1031985

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

High-throughput

0.479

High

1032000

GET4
Golgi to ER traffic protein 4 homolog

1

1

High-throughput

0.479

High

1032010

GCN1
Stalled ribosome sensor GCN1

1

9

High-throughput

0.479

High

1032020

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.479

High

1032034

FBX6
F-box only protein 6

1

9

High-throughput

0.479

High

1032035

SMC4
Structural maintenance of chromosomes protein 4

1

2

High-throughput

0.479

High

1032037

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

2

High-throughput

0.479

High

1032012

CCD47
PAT complex subunit CCDC47

1

2

High-throughput

0.470

High

1032039

RRBP1
Ribosome-binding protein 1

1

2

High-throughput

0.470

High

607649

NDKB
Nucleoside diphosphate kinase B

1

0

Small-scale

0.458

High

239975

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.445

High

496959

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

1031981

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

1032017

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

4

High-throughput

0.445

High

1032019

SCN2A
Sodium channel protein type 2 subunit alpha

1

8

High-throughput

0.445

High

1032044

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

1032036

GINM1
Glycoprotein integral membrane protein 1

3

0

High-throughput

0.347

High

311318

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

2

0

High-throughput

0.328

High

362387

CRP

2

0

High-throughput

0.328

High

1018460

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.282

High

1032040

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.282

High

1032045

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.282

High

1031994

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1031995

IL31
Interleukin-31

1

0

High-throughput

0.279

Low

1031998

SMIM5
Small integral membrane protein 5

1

0

High-throughput

0.279

Low

1032015

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

1032021

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.279

Low

1032048

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.268

Low

815240

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024