Protein: CY561
Transmembrane ascorbate-dependent reductase CYB561 (EC 7.2.1.-) (Cytochrome b-561) (Cytochrome b561)

Gene: CY561, CYB561
Organism: Homo sapiens
Interactions: 64
UniProt ID: P49447

Gene Ontology (top 5):
GO:0005765 - lysosomal membrane
GO:0006879 - intracellular iron ion homeostasis
GO:0016020 - membrane
GO:0016491 - oxidoreductase activity
GO:0022900 - electron transport chain

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

883433

EDA
Ectodysplasin-A

3

0

High-throughput

0.646

High

160247

GOSR2
Golgi SNAP receptor complex member 2

2

1

High-throughput

0.606

High

179844

BET1
BET1 homolog

2

2

High-throughput

0.606

High

483892

HMOX1
Heme oxygenase 1

2

2

High-throughput

0.606

High

883410

PLP2
Proteolipid protein 2

2

1

High-throughput

0.606

High

883416

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

2

1

High-throughput

0.606

High

883431

GPX8
Probable glutathione peroxidase 8

2

3

High-throughput

0.606

High

883434

T4S18
Transmembrane 4 L6 family member 18

2

1

High-throughput

0.606

High

883435

GIMA5
GTPase IMAP family member 5

2

3

High-throughput

0.606

High

883448

S39A1
Zinc transporter ZIP1

2

1

High-throughput

0.606

High

883454

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

1

High-throughput

0.606

High

614666

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

0

High-throughput

0.602

High

144415

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

162174

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.580

High

883419

TM128
Transmembrane protein 128

2

0

High-throughput

0.580

High

883423

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

0

High-throughput

0.580

High

883425

ANR46
Ankyrin repeat domain-containing protein 46

2

0

High-throughput

0.580

High

883427

BEST2
Bestrophin-2a

2

0

High-throughput

0.580

High

883429

CKLF2
CKLF-like MARVEL transmembrane domain-containing protein 2

2

0

High-throughput

0.580

High

883432

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.580

High

883440

S19A3
Thiamine transporter 2

2

0

High-throughput

0.580

High

883443

TREX1
Three-prime repair exonuclease 1

2

0

High-throughput

0.580

High

883445

S38A7
Sodium-coupled neutral amino acid transporter 7

2

0

High-throughput

0.580

High

883453

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.580

High

332917

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

3

High-throughput

0.553

High

338250

CLD9
Claudin-9

2

3

High-throughput

0.553

High

549745

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

2

High-throughput

0.553

High

883413

STX3
Syntaxin-3

2

2

High-throughput

0.553

High

883414

BIK
Bcl-2-interacting killer

2

1

High-throughput

0.553

High

883415

AQP6
Aquaporin-6

2

5

High-throughput

0.553

High

883422

TMM65
Transmembrane protein 65

2

1

High-throughput

0.553

High

883426

SERP2
Stress-associated endoplasmic reticulum protein 2

2

2

High-throughput

0.553

High

883430

GP152
Probable G-protein coupled receptor 152

2

2

High-throughput

0.553

High

883437

SC22A
Vesicle-trafficking protein SEC22a

2

1

High-throughput

0.553

High

883441

S39A2
Zinc transporter ZIP2

2

1

High-throughput

0.553

High

883447

ZDHC7
Palmitoyltransferase ZDHHC7

2

1

High-throughput

0.553

High

883450

VAPA
Vesicle-associated membrane protein-associated protein A

2

3

High-throughput

0.553

High

883451

LPAR3
Lysophosphatidic acid receptor 3

2

2

High-throughput

0.553

High

883439

RNF5
E3 ubiquitin-protein ligase RNF5

1

2

High-throughput

0.523

High

48189

A0AVG3
t-SNARE domain containing 1

1

4

High-throughput

0.515

High

230282

CREB3
Cyclic AMP-responsive element-binding protein 3

1

3

High-throughput

0.508

High

788295

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

3

High-throughput

0.489

High

883449

TBA8
Tubulin alpha-8 chain

1

1

High-throughput

0.481

High

883411

ECHP
Peroxisomal bifunctional enzyme

1

1

High-throughput

0.470

High

385552

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.439

High

883420

F209A
Protein FAM209A

1

1

High-throughput

0.439

High

883438

TSNA1
t-SNARE domain-containing protein 1

1

4

High-throughput

0.439

High

74157

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.316

High

602202

TMM11
Transmembrane protein 11, mitochondrial

2

0

High-throughput

0.316

High

770833

OPRM
Mu-type opioid receptor

2

0

High-throughput

0.316

High

883408

EFNA5
Ephrin-A5

2

0

High-throughput

0.316

High

883409

SYJ2B
Synaptojanin-2-binding protein

2

0

High-throughput

0.316

High

883412

SEC20
Vesicle transport protein SEC20

2

0

High-throughput

0.316

High

883417

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.316

High

883418

ORML2
ORM1-like protein 2

2

0

High-throughput

0.316

High

883421

SYDM
Aspartate--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

883424

T179B
Transmembrane protein 179B

2

0

High-throughput

0.316

High

883428

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.316

High

883436

REEP6
Receptor expression-enhancing protein 6

2

0

High-throughput

0.316

High

883442

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.316

High

883444

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

883446

TM242
Transmembrane protein 242

2

0

High-throughput

0.316

High

883452

GGT7
Glutathione hydrolase 7

2

0

High-throughput

0.316

High

883455

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025