Protein: SC11C
Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21)

Gene: SC11C, SEC11C
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q9BY50

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0008233 - peptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1136160

SPCS2
Signal peptidase complex subunit 2

4

3

High-throughput

0.892

High

956103

SPCS3
Signal peptidase complex subunit 3

3

3

High-throughput

0.855

High

1417786

SPCS1
Signal peptidase complex subunit 1

3

3

High-throughput

0.662

High

1322699

CADM3
Cell adhesion molecule 3

2

0

High-throughput

0.655

High

1358615

BT2A2
Butyrophilin subfamily 2 member A2

2

0

High-throughput

0.655

High

1360200

5HT3C
5-hydroxytryptamine receptor 3C

3

5

High-throughput

0.609

High

444683

CO2
Complement C2

2

1

High-throughput

0.606

High

1417781

VAPA
Vesicle-associated membrane protein-associated protein A

2

2

High-throughput

0.606

High

1417784

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

2

High-throughput

0.606

High

144480

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

326267

PRS23
Serine protease 23

2

0

High-throughput

0.580

High

483964

HMOX1
Heme oxygenase 1

2

0

High-throughput

0.580

High

1313644

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

0

High-throughput

0.580

High

1417779

TREX1
Three-prime repair exonuclease 1

2

0

High-throughput

0.580

High

1417788

SERP1
Stress-associated endoplasmic reticulum protein 1

2

0

High-throughput

0.580

High

761096

GBRA3
Gamma-aminobutyric acid receptor subunit alpha-3

2

3

High-throughput

0.574

High

1057581

ACHD
Acetylcholine receptor subunit delta

2

4

High-throughput

0.574

High

1323398

FXL14
F-box/LRR-repeat protein 14

2

1

High-throughput

0.574

High

1417783

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

2

3

High-throughput

0.574

High

278554

VAMP4
Vesicle-associated membrane protein 4

2

1

High-throughput

0.553

High

662360

VAMP1
Vesicle-associated membrane protein 1

2

1

High-throughput

0.553

High

1294825

STX12
Syntaxin-12

2

2

High-throughput

0.553

High

851208

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

2

3

High-throughput

0.549

High

1381341

NCLN
BOS complex subunit NCLN

1

1

High-throughput

0.536

High

1382182

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1417775

LMA1L
Protein ERGIC-53-like

1

0

High-throughput

0.513

High

1333892

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

0

High-throughput

0.493

High

607983

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

4

High-throughput

0.489

High

880060

DNSL1
Deoxyribonuclease-1-like 1

1

1

High-throughput

0.489

High

1048804

ACHE
Acetylcholine receptor subunit epsilon

1

4

High-throughput

0.489

High

1417774

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.489

High

1417787

WNT6
Protein Wnt-6

1

1

High-throughput

0.489

High

48203

A0AVG3
t-SNARE domain containing 1

1

2

High-throughput

0.470

High

328731

VAMP5
Vesicle-associated membrane protein 5

1

2

High-throughput

0.470

High

631690

RAB6A
Ras-related protein Rab-6A

1

2

High-throughput

0.445

High

1398899

TSNA1
t-SNARE domain-containing protein 1

1

2

High-throughput

0.439

High

1392457

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

437781

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

248939

GSDME
Gasdermin-E

1

1

High-throughput

0.407

High

1417776

FBX6
F-box only protein 6

1

2

High-throughput

0.407

High

1417777

RAB6B
Ras-related protein Rab-6B

1

2

High-throughput

0.407

High

1417780

CC50A
Cell cycle control protein 50A

3

0

High-throughput

0.347

High

1324308

GHDC
GH3 domain-containing protein

3

0

High-throughput

0.345

High

337192

APOM
Apolipoprotein M

2

0

High-throughput

0.328

High

426035

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

2

0

High-throughput

0.328

High

1316366

AGRG5
Adhesion G-protein coupled receptor G5

2

0

High-throughput

0.328

High

1416207

FUND2
FUN14 domain-containing protein 2

2

0

High-throughput

0.328

High

1417778

TOM22
Mitochondrial import receptor subunit TOM22 homolog

2

0

High-throughput

0.328

High

1417782

GGT7
Glutathione hydrolase 7

2

0

High-throughput

0.328

High

1203343

TM128
Transmembrane protein 128

2

0

High-throughput

0.316

High

1208735

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.316

High

1229451

TMM42
Transmembrane protein 42

2

0

High-throughput

0.316

High

1349014

TM254
Transmembrane protein 254

2

0

High-throughput

0.316

High

1359856

SELM
Selenoprotein M

2

0

High-throughput

0.316

High

1414031

TM243
Transmembrane protein 243

2

0

High-throughput

0.316

High

1417773

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High

884701

SYHM
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

846094

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.251

Low

1412974

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

65812

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.232

Low

373063

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.232

Low

1235942

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.232

Low

1310167

GCC2
GRIP and coiled-coil domain-containing protein 2

1

0

High-throughput

0.232

Low

1389580

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

1417609

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low

1417785

RAP2C
Ras-related protein Rap-2c

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025