Protein: UBS3B
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)

Gene: UBS3B, UBASH3B
Organism: Homo sapiens
Interactions: 165
UniProt ID: Q8TF42

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0009968 - negative regulation of signal transduction
GO:0031625 - ubiquitin protein ligase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363613

EGFR
Epidermal growth factor receptor

10

20

Small-scale

0.968

High

508329

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

7

14

Small-scale

0.955

High

1353513

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

4

17

High-throughput

0.896

High

849212

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.834

High

834214

CSK
Tyrosine-protein kinase CSK

2

20

High-throughput

0.789

High

211994

EFS
Embryonal Fyn-associated substrate

2

19

High-throughput

0.783

High

332425

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

2

3

High-throughput

0.783

High

1353526

ZN363
RING finger and CHY zinc finger domain-containing protein 1

5

0

High-throughput

0.694

High

840922

TXK
Tyrosine-protein kinase TXK

1

20

High-throughput

0.691

High

855699

CRK
Adapter molecule crk

1

20

High-throughput

0.691

High

242389

PRKN
E3 ubiquitin-protein ligase parkin

1

10

Small-scale

0.681

High

1139091

DAZP2
DAZ-associated protein 2

3

2

High-throughput

0.675

High

1353534

VP37B
Vacuolar protein sorting-associated protein 37B

3

17

High-throughput

0.675

High

1122791

DOC2A
Double C2-like domain-containing protein alpha

6

3

High-throughput

0.672

High

1053260

Q05BL1
TP53BP2 protein

1

10

High-throughput

0.665

High

651386

CBL
E3 ubiquitin-protein ligase CBL

6

20

Small-scale

0.664

High

987794

GRB2
Growth factor receptor-bound protein 2

3

20

Small-scale

0.650

High

1097949

CBLB
E3 ubiquitin-protein ligase CBL-B

4

20

Small-scale

0.637

High

1207564

F209A
Protein FAM209A

3

0

High-throughput

0.629

High

213977

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

12

Small-scale

0.625

High

1115568

ASPP2
Apoptosis-stimulating of p53 protein 2

1

14

High-throughput

0.621

High

362327

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

943799

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

17

High-throughput

0.618

High

987133

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

8

High-throughput

0.618

High

772923

MYH9
Myosin-9

2

7

High-throughput

0.611

High

1353516

F168A
Protein FAM168A

3

2

High-throughput

0.609

High

711382

SHC1
SHC-transforming protein 1

3

20

Small-scale

0.606

High

133673

WASL
Actin nucleation-promoting factor WASL

2

20

High-throughput

0.606

High

246809

KDM1A
Lysine-specific histone demethylase 1A

2

2

High-throughput

0.606

High

297841

PIAS2
E3 SUMO-protein ligase PIAS2

2

1

High-throughput

0.606

High

574029

HXB2
Homeobox protein Hox-B2

2

4

High-throughput

0.606

High

587156

ITF2
Transcription factor 4

2

1

High-throughput

0.606

High

633754

PSB1
Proteasome subunit beta type-1

2

2

High-throughput

0.606

High

681883

RBTN2
Rhombotin-2

2

11

High-throughput

0.606

High

1048933

REL
Proto-oncogene c-Rel

2

6

High-throughput

0.606

High

1081417

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

1163744

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

20

High-throughput

0.606

High

1213789

KPRP
Keratinocyte proline-rich protein

2

3

High-throughput

0.606

High

1331900

DTX3
Probable E3 ubiquitin-protein ligase DTX3

2

6

High-throughput

0.606

High

1353523

AP4AT
AP-4 complex accessory subunit Tepsin

2

2

High-throughput

0.606

High

1353539

RN216
E3 ubiquitin-protein ligase RNF216

2

4

High-throughput

0.606

High

537586

HSP7C
Heat shock cognate 71 kDa protein

2

7

High-throughput

0.584

High

952980

ACTB
Actin, cytoplasmic 1

2

20

High-throughput

0.584

High

1353519

KAT5
Histone acetyltransferase KAT5

2

0

High-throughput

0.580

High

410960

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

1062997

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

1328370

CCD33
Coiled-coil domain-containing protein 33

2

1

High-throughput

0.574

High

221162

SPY2
Protein sprouty homolog 2

1

20

High-throughput

0.573

High

1353537

DMRT3
Doublesex- and mab-3-related transcription factor 3

1

3

High-throughput

0.573

High

1353521

AURKB
Aurora kinase B

1

7

Small-scale

0.561

High

72386

A9UF07
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.559

High

506754

PRR35
Proline-rich protein 35

2

1

High-throughput

0.553

High

1353530

LZTS2
Leucine zipper putative tumor suppressor 2

2

20

High-throughput

0.553

High

1353538

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.553

High

1353541

DLGP2
Disks large-associated protein 2

2

14

High-throughput

0.553

High

187383

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

High-throughput

0.536

High

318366

MYO1D
Unconventional myosin-Id

1

9

High-throughput

0.536

High

424234

S10A8
Protein S100-A8

1

4

High-throughput

0.536

High

649378

H1T
Histone H1t

1

6

High-throughput

0.536

High

650868

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

9

High-throughput

0.536

High

938760

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

13

High-throughput

0.536

High

1037287

H11
Histone H1.1

1

6

High-throughput

0.536

High

1353518

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

1353524

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

16

High-throughput

0.536

High

1353544

ERRFI
ERBB receptor feedback inhibitor 1

1

14

High-throughput

0.536

High

1254332

S2548
Solute carrier family 25 member 48

1

6

High-throughput

0.523

High

1353543

MSRA
Mitochondrial peptide methionine sulfoxide reductase

1

0

High-throughput

0.513

High

1353533

RNF41
E3 ubiquitin-protein ligase NRDP1

1

15

Small-scale

0.512

High

144184

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

7

Small-scale

0.501

High

906719

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

6

Small-scale

0.501

High

909358

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

6

Small-scale

0.501

High

957146

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

6

Small-scale

0.501

High

970828

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

Small-scale

0.501

High

982258

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

6

Small-scale

0.501

High

1098814

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

5

Small-scale

0.501

High

1113817

CUL3
Cullin-3

1

9

Small-scale

0.501

High

386479

SPTA1
Spectrin alpha chain, erythrocytic 1

1

17

High-throughput

0.489

High

868978

NPTX2
Neuronal pentraxin-2

1

1

High-throughput

0.489

High

1010502

EREP3
Protein ENTREP3

1

2

High-throughput

0.489

High

1064458

DSC1
Desmocollin-1

1

7

High-throughput

0.489

High

1236056

PRR27
Proline-rich protein 27

1

10

High-throughput

0.489

High

1353535

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.489

High

177914

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

5

Small-scale

0.484

High

1153073

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

2

Small-scale

0.484

High

1353527

WRIP1
ATPase WRNIP1

1

2

Small-scale

0.484

High

1353540

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

10

Small-scale

0.484

High

1353542

TBK1
Serine/threonine-protein kinase TBK1

1

5

Small-scale

0.484

High

1353528

PKP4
Plakophilin-4

1

5

High-throughput

0.481

High

224754

ACTN4
Alpha-actinin-4

1

12

High-throughput

0.479

High

331179

KI20A
Kinesin-like protein KIF20A

1

13

Small-scale

0.479

High

343268

ERR2
Steroid hormone receptor ERR2

1

8

High-throughput

0.479

High

385146

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.479

High

385306

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.479

High

407494

K2C1
Keratin, type II cytoskeletal 1

1

19

High-throughput

0.479

High

437284

K2C8
Keratin, type II cytoskeletal 8

1

20

High-throughput

0.479

High

457582

TBB5
Tubulin beta chain

1

5

High-throughput

0.479

High

461751

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.479

High

468638

HS90B
Heat shock protein HSP 90-beta

1

7

High-throughput

0.479

High

476364

K1C16
Keratin, type I cytoskeletal 16

1

20

High-throughput

0.479

High

521830

H14
Histone H1.4

1

6

High-throughput

0.479

High

535334

BIP
Endoplasmic reticulum chaperone BiP

1

10

High-throughput

0.479

High

566190

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.479

High

566426

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.479

High

570520

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.479

High

594055

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.479

High

595830

H13
Histone H1.3

1

6

High-throughput

0.479

High

596259

H12
Histone H1.2

1

6

High-throughput

0.479

High

610796

TCPA
T-complex protein 1 subunit alpha

1

6

High-throughput

0.479

High

684324

DDX6
Probable ATP-dependent RNA helicase DDX6

1

7

High-throughput

0.479

High

711727

RABP2
Cellular retinoic acid-binding protein 2

1

2

High-throughput

0.479

High

727897

DNJA1
DnaJ homolog subfamily A member 1

1

4

High-throughput

0.479

High

729368

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

14

High-throughput

0.479

High

761462

HS71L
Heat shock 70 kDa protein 1-like

1

7

High-throughput

0.479

High

772035

K1C9
Keratin, type I cytoskeletal 9

1

20

High-throughput

0.479

High

773233

MYH10
Myosin-10

1

7

High-throughput

0.479

High

777524

K22E
Keratin, type II cytoskeletal 2 epidermal

1

20

High-throughput

0.479

High

821474

TCPZ
T-complex protein 1 subunit zeta

1

6

High-throughput

0.479

High

862918

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

8

High-throughput

0.479

High

899149

TCPQ
T-complex protein 1 subunit theta

1

9

High-throughput

0.479

High

912981

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

13

High-throughput

0.479

High

993261

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.479

High

996784

TBA1B
Tubulin alpha-1B chain

1

6

High-throughput

0.479

High

1027616

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.479

High

1028825

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

19

High-throughput

0.479

High

1033088

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

1109931

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

1132851

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

Small-scale

0.479

High

1254791

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.479

High

1294689

K2C73
Keratin, type II cytoskeletal 73

1

20

High-throughput

0.479

High

1353517

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.479

High

1353529

TCPH
T-complex protein 1 subunit eta

1

7

High-throughput

0.479

High

282278

SAP30
Histone deacetylase complex subunit SAP30

1

0

Small-scale

0.458

High

167937

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

4

Small-scale

0.445

High

639275

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

7

Small-scale

0.445

High

1090816

TRAF2
TNF receptor-associated factor 2

1

13

Small-scale

0.445

High

1107436

BIRC2
Baculoviral IAP repeat-containing protein 2

1

6

Small-scale

0.445

High

1150552

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

1

Small-scale

0.445

High

1353520

RNF31
E3 ubiquitin-protein ligase RNF31

1

9

Small-scale

0.445

High

1353546

SPAT2
Spermatogenesis-associated protein 2

1

1

Small-scale

0.445

High

1353547

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.445

High

1353548

NEMO
NF-kappa-B essential modulator

1

13

Small-scale

0.445

High

1353536

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

Small-scale

0.442

High

407322

K2C6B
Keratin, type II cytoskeletal 6B

1

20

High-throughput

0.437

High

540057

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.437

High

882060

TCPG
T-complex protein 1 subunit gamma

1

7

High-throughput

0.437

High

1047455

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.437

High

1063823

LG3BP
Galectin-3-binding protein

1

5

High-throughput

0.437

High

1094219

ACACA
Acetyl-CoA carboxylase 1

1

1

High-throughput

0.437

High

1117418

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

17

High-throughput

0.437

High

1220469

K2C79
Keratin, type II cytoskeletal 79

1

20

High-throughput

0.437

High

1353515

TCPW
T-complex protein 1 subunit zeta-2

1

8

High-throughput

0.437

High

1353545

COR1C
Coronin-1C

1

6

High-throughput

0.437

High

1119219

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1059903

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

5

Small-scale

0.408

High

378145

TNFA
Tumor necrosis factor

1

3

Small-scale

0.407

High

622644

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

5

Small-scale

0.407

High

1353531

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

3

Small-scale

0.407

High

1353532

SHRPN
Sharpin

1

1

Small-scale

0.407

High

1353522

CC74B
Coiled-coil domain-containing protein 74B

2

0

High-throughput

0.316

High

1353525

BBC3B
Bcl-2-binding component 3, isoforms 3/4

2

0

High-throughput

0.316

High

1324722

CBARP
Voltage-dependent calcium channel beta subunit-associated regulatory protein

1

0

High-throughput

0.279

Low

1010678

DCD
Dermcidin

1

0

High-throughput

0.249

Low

1206208

T255A
Transmembrane protein 255A

1

0

High-throughput

0.249

Low

1353514

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025