Protein: LYST
Lysosomal-trafficking regulator (Beige homolog)

Gene: LYST
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q99698

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0006909 - phagocytosis
GO:0015031 - protein transport
GO:0015630 - microtubule cytoskeleton
GO:0030595 - leukocyte chemotaxis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1241029

L2GL2
LLGL scribble cell polarity complex component 2

1

8

High-throughput

0.691

High

1406456

MTA3
Metastasis-associated protein MTA3

1

7

High-throughput

0.618

High

995220

CSK2B
Casein kinase II subunit beta

2

3

Small-scale

0.606

High

990654

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.595

High

691369

1433T
14-3-3 protein theta

2

20

Small-scale

0.586

High

730188

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.586

High

625581

CSK22
Casein kinase II subunit alpha'

2

10

High-throughput

0.558

High

316962

MTA2
Metastasis-associated protein MTA2

1

4

High-throughput

0.553

High

1406466

APC4
Anaphase-promoting complex subunit 4

1

1

Small-scale

0.553

High

230563

KIF1C
Kinesin-like protein KIF1C

1

4

High-throughput

0.536

High

281089

TACC1
Transforming acidic coiled-coil-containing protein 1

1

12

High-throughput

0.536

High

986665

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.536

High

1242692

KLC3
Kinesin light chain 3

1

4

High-throughput

0.536

High

1406467

MYH13
Myosin-13

1

6

High-throughput

0.536

High

1387396

ESS2
Splicing factor ESS-2 homolog

1

0

Small-scale

0.519

High

902569

RT29
Small ribosomal subunit protein mS29

1

4

High-throughput

0.489

High

938783

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

20

High-throughput

0.489

High

1406463

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.489

High

169725

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

Small-scale

0.481

High

211997

EFS
Embryonal Fyn-associated substrate

1

5

Small-scale

0.481

High

543593

ERR1
Steroid hormone receptor ERR1

1

9

Small-scale

0.481

High

928328

ATN1
Atrophin-1

1

15

Small-scale

0.481

High

944898

PCBP4
Poly(rC)-binding protein 4

1

17

Small-scale

0.481

High

1134350

IMB1
Importin subunit beta-1

1

6

Small-scale

0.481

High

1251344

DJC14
DnaJ homolog subfamily C member 14

1

14

Small-scale

0.481

High

1406457

CELF4
CUGBP Elav-like family member 4

1

15

Small-scale

0.481

High

1406459

CPAP
Centrosomal P4.1-associated protein

1

15

Small-scale

0.481

High

1406460

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

1

Small-scale

0.481

High

352234

MBD3
Methyl-CpG-binding domain protein 3

1

2

High-throughput

0.479

High

372953

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

730853

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

901523

RAB7A
Ras-related protein Rab-7a

1

16

High-throughput

0.479

High

966795

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

971927

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.479

High

1049708

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1105656

GOGA4
Golgin subfamily A member 4

1

17

High-throughput

0.479

High

1129117

PLSI
Plastin-1

1

10

High-throughput

0.479

High

1406458

ECT2
Protein ECT2

1

11

High-throughput

0.479

High

1406464

BCLF1
Bcl-2-associated transcription factor 1

1

10

High-throughput

0.479

High

910652

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

14

Small-scale

0.439

High

1322781

CNTRB
Centrobin

1

14

Small-scale

0.439

High

1366411

RT31
Small ribosomal subunit protein mS31

1

2

Small-scale

0.439

High

1372184

MED12
Mediator of RNA polymerase II transcription subunit 12

1

10

Small-scale

0.439

High

406552

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.437

High

997969

CSK21
Casein kinase II subunit alpha

1

10

High-throughput

0.437

High

1015290

ERH
Enhancer of rudimentary homolog

1

3

High-throughput

0.437

High

1180481

C19L2
CWF19-like protein 2

1

1

High-throughput

0.437

High

1337833

CSK23
Casein kinase II subunit alpha 3

1

6

High-throughput

0.437

High

1406461

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.417

High

282297

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.279

Low

827470

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.279

Low

622507

TNNI3
Troponin I, cardiac muscle

1

0

Small-scale

0.251

Low

1395855

ZN521
Zinc finger protein 521

1

0

Small-scale

0.251

Low

1406462

RM17
Large ribosomal subunit protein bL17m

1

0

Small-scale

0.251

Low

1406465

NCDN
Neurochondrin

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025