Protein: PFD6
Prefoldin subunit 6 (Genes involved in microtubule biogenesis protein 1) (Gim complex subunit 1) (GimC subunit 1)

Gene: PFD6, YKE2
Organism: Saccharomyces cerevisiae S288C
Interactions: 206
UniProt ID: P52553

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006457 - protein folding
GO:0007021 - tubulin complex assembly
GO:0015631 - tubulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

871534

PFD3
Prefoldin subunit 3

8

2

Small-scale

0.971

High

912443

PFD5
Prefoldin subunit 5

7

4

Small-scale

0.962

High

912422

PFD4
Prefoldin subunit 4

6

2

High-throughput

0.951

High

849825

BUD27
Bud site selection protein 27

8

0

Small-scale

0.916

High

816726

PFD2
Prefoldin subunit 2

4

2

Small-scale

0.896

High

863654

PFD1
Prefoldin subunit 1

3

0

High-throughput

0.764

High

594467

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

1

Small-scale

0.640

High

632189

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

1

High-throughput

0.628

High

912411

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.621

High

866046

NNF1
Kinetochore-associated protein NNF1

2

0

High-throughput

0.570

High

475131

CYAA
Adenylate cyclase

2

0

High-throughput

0.563

High

753120

NIP80
Protein NIP100

2

0

High-throughput

0.552

High

554025

TCPA
T-complex protein 1 subunit alpha

1

0

Small-scale

0.546

High

810730

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.546

High

524560

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.536

High

793956

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

6

High-throughput

0.536

High

817460

TDA2
Topoisomerase I damage affected protein 2

1

0

High-throughput

0.518

High

912418

TBG
Tubulin gamma chain

1

7

Small-scale

0.515

High

534283

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

3

High-throughput

0.481

High

598421

TUP1
General transcriptional corepressor TUP1

1

7

High-throughput

0.481

High

815652

LIS1
Nuclear distribution protein PAC1

1

7

High-throughput

0.481

High

402056

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

High-throughput

0.479

High

647167

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.479

High

438320

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.460

High

597210

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.460

High

744889

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

0

High-throughput

0.460

High

781572

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.460

High

802521

SYSM
Serine--tRNA ligase, mitochondrial

1

0

High-throughput

0.460

High

809203

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.460

High

817009

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

858340

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.460

High

912433

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.460

High

912439

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.460

High

912477

SRN2
Protein SRN2

1

0

High-throughput

0.460

High

707641

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

809466

MPT5
Suppressor protein MPT5

1

0

High-throughput

0.458

High

912467

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

486253

TBA1
Tubulin alpha-1 chain

1

7

Small-scale

0.445

High

486491

TBA3
Tubulin alpha-3 chain

1

7

High-throughput

0.445

High

504581

YD15B
Transposon Ty1-DR6 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

527177

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

609074

SKI3
Superkiller protein 3

1

1

High-throughput

0.445

High

644957

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

4

High-throughput

0.445

High

672775

SNT1
Probable DNA-binding protein SNT1

1

1

High-throughput

0.445

High

739167

PRP19
Pre-mRNA-processing factor 19

1

6

High-throughput

0.445

High

741977

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

747744

SMC1
Structural maintenance of chromosomes protein 1

1

1

High-throughput

0.445

High

822459

TBP6
Probable 26S proteasome subunit YTA6

1

1

High-throughput

0.445

High

823001

ATAD2
ATPase histone chaperone YTA7

1

1

High-throughput

0.445

High

824851

NDC80
Kinetochore protein NDC80

1

1

High-throughput

0.445

High

864475

MTR4
ATP-dependent RNA helicase DOB1

1

1

High-throughput

0.445

High

912427

ACT
Actin

1

2

Small-scale

0.445

High

912441

YM13B
Transposon Ty1-MR1 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

912456

CDC73
Cell division control protein 73

1

1

High-throughput

0.445

High

359288

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

High-throughput

0.426

High

382221

H4
Histone H4

1

0

High-throughput

0.426

High

394721

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

432344

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.426

High

460993

LTE1
Guanine nucleotide exchange factor LTE1

1

0

High-throughput

0.426

High

477595

MYO1
Myosin-1

1

0

High-throughput

0.426

High

545559

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

560735

KIN2
Serine/threonine-protein kinase KIN2

1

0

High-throughput

0.426

High

636597

PSA7
Probable proteasome subunit alpha type-7

1

0

High-throughput

0.426

High

655590

TKT1
Transketolase 1

1

0

High-throughput

0.426

High

662092

MPIP
M-phase inducer phosphatase

1

0

High-throughput

0.426

High

682885

MSH1
DNA mismatch repair protein MSH1, mitochondrial

1

0

High-throughput

0.426

High

712811

CHS3
Chitin synthase 3

1

0

High-throughput

0.426

High

721389

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.426

High

743113

STH1
Nuclear protein STH1/NPS1

1

0

High-throughput

0.426

High

745486

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.426

High

745527

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.426

High

748141

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.426

High

750733

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.426

High

750869

PRS6B
26S proteasome regulatory subunit 6B homolog

1

0

High-throughput

0.426

High

757896

UBX1
UBX domain-containing protein 1

1

0

High-throughput

0.426

High

762847

TOR1
Serine/threonine-protein kinase TOR1

1

0

High-throughput

0.426

High

763594

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.426

High

780619

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.426

High

791915

AAP1
Alanine/arginine aminopeptidase

1

0

High-throughput

0.426

High

792422

BOI1
BEM1-interacting protein 1

1

0

High-throughput

0.426

High

792686

RIB1
GTP cyclohydrolase-2

1

0

High-throughput

0.426

High

797893

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.426

High

798504

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

1

0

High-throughput

0.426

High

801156

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.426

High

802797

OSH3
Oxysterol-binding protein homolog 3

1

0

High-throughput

0.426

High

804728

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.426

High

813560

MET10
Sulfite reductase [NADPH] flavoprotein component

1

0

High-throughput

0.426

High

816577

YEC5
Uncharacterized protein YEL025C

1

0

High-throughput

0.426

High

817195

CHZ1
Histone H2A.Z-specific chaperone CHZ1

1

0

High-throughput

0.426

High

824489

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

824607

YIR7
Y' element ATP-dependent helicase YIL177C

1

0

High-throughput

0.426

High

825695

SER33
D-3-phosphoglycerate dehydrogenase 2

1

0

High-throughput

0.426

High

825703

SPO22
Sporulation-specific protein 22

1

0

High-throughput

0.426

High

825721

CSN11
Cop9 signalosome complex subunit 11

1

0

High-throughput

0.426

High

826240

VID28
GID complex subunit 5

1

0

High-throughput

0.426

High

858106

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

864263

ALY2
Arrestin-related trafficking adapter 3

1

0

High-throughput

0.426

High

865886

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

866225

MET5
Sulfite reductase [NADPH] subunit beta

1

0

High-throughput

0.426

High

871103

GTO1
Glutathione S-transferase omega-like 1

1

0

High-throughput

0.426

High

893393

LGUL
Glyoxalase I

1

0

High-throughput

0.426

High

908506

ROM2
RHO1 GDP-GTP exchange protein 2

1

0

High-throughput

0.426

High

912414

MDS3
Negative regulator of sporulation MDS3

1

0

High-throughput

0.426

High

912415

MED5
Mediator of RNA polymerase II transcription subunit 5

1

0

High-throughput

0.426

High

912417

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.426

High

912419

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.426

High

912421

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.426

High

912425

IDHH
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

912426

UFD2
E4 ubiquitin-protein ligase UFD2

1

0

High-throughput

0.426

High

912430

SEN1
Helicase SEN1

1

0

High-throughput

0.426

High

912435

ESP1
Separin

1

0

High-throughput

0.426

High

912442

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.426

High

912445

SWR1
Helicase SWR1

1

0

High-throughput

0.426

High

912448

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

High-throughput

0.426

High

912449

ECM22
Sterol regulatory element-binding protein ECM22

1

0

High-throughput

0.426

High

912451

VPS74
Vacuolar protein sorting-associated protein 74

1

0

High-throughput

0.426

High

912458

SYG2
Glycine--tRNA ligase 2

1

0

High-throughput

0.426

High

912459

YD144
Uncharacterized protein YDL144C

1

0

High-throughput

0.426

High

912461

NOC3
Nucleolar complex-associated protein 3

1

0

High-throughput

0.426

High

912462

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

High-throughput

0.426

High

912463

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.426

High

912464

DIA2
Protein DIA2

1

0

High-throughput

0.426

High

912465

PUS7
Multisubstrate pseudouridine synthase 7

1

0

High-throughput

0.426

High

912466

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.426

High

912468

KPR5
Ribose-phosphate pyrophosphokinase 5

1

0

High-throughput

0.426

High

912469

INP53
Polyphosphatidylinositol phosphatase INP53

1

0

High-throughput

0.426

High

912470

HER1
HMG2-induced ER-remodeling protein 1

1

0

High-throughput

0.426

High

912472

SFI1
Protein SFI1

1

0

High-throughput

0.426

High

912474

KCS1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.426

High

912475

DCP1
mRNA-decapping enzyme subunit 1

1

0

High-throughput

0.426

High

912478

DDP1
Diphosphoinositol polyphosphate phosphohydrolase DDP1

1

0

High-throughput

0.426

High

734340

DGR2
2-deoxy-glucose resistant protein 2

1

7

High-throughput

0.407

High

779684

YPT53
GTP-binding protein YPT53

1

1

High-throughput

0.407

High

912434

YP113
Putative 2-hydroxyacid dehydrogenase YPL113C

1

1

High-throughput

0.407

High

912455

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

1

High-throughput

0.407

High

817742

TSC11
Target of rapamycin complex 2 subunit TSC11

2

0

High-throughput

0.300

High

836619

PXA1
Peroxisomal long-chain fatty acid import protein 2

1

0

High-throughput

0.282

High

912476

YB296
Uncharacterized protein YBR296C-A

1

0

High-throughput

0.282

High

858261

FAR3
Factor arrest protein 3

1

0

High-throughput

0.265

Low

758480

SEG2
Eisosome protein SEG2

1

0

High-throughput

0.251

Low

790334

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.251

Low

797184

ATG14
Autophagy-related protein 14

1

0

High-throughput

0.251

Low

849533

GCN20
Protein GCN20

1

0

High-throughput

0.251

Low

893103

KEL2
Kelch repeat-containing protein 2

1

0

High-throughput

0.251

Low

912440

SHE9
Sensitive to high expression protein 9, mitochondrial

1

0

High-throughput

0.251

Low

912447

ENT2
Epsin-2

1

0

High-throughput

0.251

Low

912473

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.251

Low

448899

TYSY
Thymidylate synthase

1

0

High-throughput

0.232

Low

503935

RL27B
Large ribosomal subunit protein eL27B

1

0

High-throughput

0.232

Low

561707

HAP3
Transcriptional activator HAP3

1

0

High-throughput

0.232

Low

577325

NSP1
Nucleoporin NSP1

1

0

High-throughput

0.232

Low

596821

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

1

0

High-throughput

0.232

Low

640723

RT28
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.232

Low

673457

ADH7
NADP-dependent alcohol dehydrogenase 7

1

0

High-throughput

0.232

Low

673667

USO1
Intracellular protein transport protein USO1

1

0

High-throughput

0.232

Low

698114

PEP3
Vacuolar membrane protein PEP3

1

0

High-throughput

0.232

Low

726026

LDS1
Outer spore wall protein LDS1

1

0

High-throughput

0.232

Low

726105

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

0

High-throughput

0.232

Low

738674

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.232

Low

745411

ZRT1
Zinc-regulated transporter 1

1

0

High-throughput

0.232

Low

754493

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.232

Low

778828

PMIP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.232

Low

779140

DHR2
Probable ATP-dependent RNA helicase DHR2

1

0

High-throughput

0.232

Low

780415

RT22
Ribosome assembly protein RSM22, mitochondrial

1

0

High-throughput

0.232

Low

782258

YK50
Mitochondrial hydrolase YKR070W

1

0

High-throughput

0.232

Low

793498

MAK5
ATP-dependent RNA helicase MAK5

1

0

High-throughput

0.232

Low

796235

FAT1
Very long-chain fatty acid transport protein

1

0

High-throughput

0.232

Low

797233

CCZ1
Vacuolar fusion protein CCZ1

1

0

High-throughput

0.232

Low

798396

POP4
RNases MRP/P 32.9 kDa subunit

1

0

High-throughput

0.232

Low

799738

YM8C
Uncharacterized deoxyribonuclease YMR262W

1

0

High-throughput

0.232

Low

803002

COS8
Protein COS8

1

0

High-throughput

0.232

Low

805066

RPF1
Ribosome production factor 1

1

0

High-throughput

0.232

Low

806006

LAM1
Membrane-anchored lipid-binding protein LAM1

1

0

High-throughput

0.232

Low

808411

HAL5
Serine/threonine-protein kinase HAL5

1

0

High-throughput

0.232

Low

812972

YAO0
Putative uncharacterized protein YAR070C

1

0

High-throughput

0.232

Low

823204

ATF1
Alcohol O-acetyltransferase 1

1

0

High-throughput

0.232

Low

836607

PTE1
Peroxisomal acyl-coenzyme A thioester hydrolase 1

1

0

High-throughput

0.232

Low

858381

STU2
Protein STU2

1

0

High-throughput

0.232

Low

864729

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.232

Low

866157

YJ94
Uncharacterized membrane protein YJR124C

1

0

High-throughput

0.232

Low

866231

IML1
Vacuolar membrane-associated protein IML1

1

0

High-throughput

0.232

Low

871030

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.232

Low

910816

PPAD
Probable acid phosphatase DIA3

1

0

High-throughput

0.232

Low

912412

CWH41
Mannosyl-oligosaccharide glucosidase

1

0

High-throughput

0.232

Low

912413

SHE10
Outer spore wall assembly protein SHE10

1

0

High-throughput

0.232

Low

912416

FMP48
Probable serine/threonine-protein kinase FMP48

1

0

High-throughput

0.232

Low

912420

PRM1
Plasma membrane fusion protein PRM1

1

0

High-throughput

0.232

Low

912423

YNI9
Putative uncharacterized protein YNL089C

1

0

High-throughput

0.232

Low

912424

SFB2
SED5-binding protein 2

1

0

High-throughput

0.232

Low

912428

CACM
Putative mitochondrial carnitine O-acetyltransferase

1

0

High-throughput

0.232

Low

912429

ATPJ
ATP synthase subunit e, mitochondrial

1

0

High-throughput

0.232

Low

912431

ACAC
Acetyl-CoA carboxylase

1

0

High-throughput

0.232

Low

912432

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

0

High-throughput

0.232

Low

912436

TCB3
Tricalbin-3

1

0

High-throughput

0.232

Low

912437

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

0

High-throughput

0.232

Low

912438

AIM36
Altered inheritance of mitochondria protein 36, mitochondrial

1

0

High-throughput

0.232

Low

912444

YMI9
Putative uncharacterized protein YML089C

1

0

High-throughput

0.232

Low

912446

SGPL
Sphingosine-1-phosphate lyase

1

0

High-throughput

0.232

Low

912450

ATG39
Autophagy-related protein 39

1

0

High-throughput

0.232

Low

912452

TAZ
Tafazzin

1

0

High-throughput

0.232

Low

912453

SUE1
Protein SUE1, mitochondrial

1

0

High-throughput

0.232

Low

912454

YD306
F-box protein YDR306C

1

0

High-throughput

0.232

Low

912457

YP078
Uncharacterized protein YPR078C

1

0

High-throughput

0.232

Low

912460

BRE4
Protein BRE4

1

0

High-throughput

0.232

Low

912471

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025