Protein: LAC1
Ceramide synthase LAC1 (Very-long-chain ceramide synthase LAC1) (EC 2.3.1.297)

Gene: LAC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 99
UniProt ID: P28496

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0034399 - nuclear periphery
GO:0046513 - ceramide biosynthetic process
GO:0050291 - sphingosine N-acyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703813

LAG1
Ceramide synthase LAG1

5

7

Small-scale

0.934

High

703789

LAC1
Ceramide synthase LAC1

2

7

High-throughput

0.791

High

703845

LIP1
Ceramide synthase subunit LIP1

4

1

Small-scale

0.706

High

703801

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

2

1

High-throughput

0.614

High

703804

YET1
Endoplasmic reticulum transmembrane protein 1

2

5

High-throughput

0.614

High

703808

PHO88
SRP-independent targeting protein 3

2

1

High-throughput

0.614

High

703821

ELO3
Fatty acid elongase 3

2

8

High-throughput

0.614

High

528556

CP51
Lanosterol 14-alpha demethylase CYP51

2

0

High-throughput

0.605

High

673408

AGP1
General amino acid permease AGP1

1

5

High-throughput

0.541

High

703805

TPO5
Polyamine transporter TPO5

1

6

High-throughput

0.541

High

703809

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

1

High-throughput

0.541

High

703831

SPC1
Signal peptidase complex subunit 1

1

2

High-throughput

0.541

High

703834

GPI8
GPI-anchor transamidase

1

1

High-throughput

0.541

High

703838

ERG25
C-4 methylsterol oxidase ERG25

1

1

High-throughput

0.541

High

703841

TNA1
High-affinity nicotinic acid transporter

1

2

High-throughput

0.541

High

703856

TECR
Very-long-chain enoyl-CoA reductase

1

1

High-throughput

0.541

High

703811

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.518

High

703812

BSD2
Metal homeostatis protein BSD2

1

0

High-throughput

0.518

High

703817

FET3
Iron transport multicopper oxidase FET3

1

0

High-throughput

0.518

High

703822

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.518

High

703825

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.518

High

703829

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.518

High

703830

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

703848

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.518

High

703853

YP264
Probable transport protein YPL264C

1

0

High-throughput

0.518

High

544054

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.504

High

703806

AVT3
Vacuolar amino acid transporter 3

1

1

High-throughput

0.494

High

703815

COS8
Protein COS8

1

1

High-throughput

0.494

High

703826

GST1
Glutathione S-transferase 1

1

0

High-throughput

0.486

High

577050

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.479

High

703792

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

5

High-throughput

0.479

High

703802

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

5

High-throughput

0.479

High

703832

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

5

High-throughput

0.479

High

703840

ORM1
Protein ORM1

1

2

Small-scale

0.479

High

703842

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

1

High-throughput

0.479

High

703851

ORM2
Protein ORM2

1

2

Small-scale

0.479

High

703852

YET3
Endoplasmic reticulum transmembrane protein 3

1

5

High-throughput

0.479

High

703816

TEM1
Protein TEM1

1

1

High-throughput

0.464

High

677991

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

441059

KAPA
cAMP-dependent protein kinase type 1

1

2

High-throughput

0.457

High

448662

SNF1
Carbon catabolite-derepressing protein kinase

1

2

High-throughput

0.457

High

554672

YPK1
Serine/threonine-protein kinase YPK1

1

4

Small-scale

0.457

High

679447

CDC48
Cell division control protein 48

1

1

High-throughput

0.445

High

578975

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.437

High

703844

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

486068

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

703849

SGPL
Sphingosine-1-phosphate lyase

1

0

High-throughput

0.426

High

392354

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.417

High

416089

SYTC
Threonine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.407

High

526095

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

535987

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

2

High-throughput

0.407

High

592065

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

603422

VATA
V-type proton ATPase catalytic subunit A

1

4

High-throughput

0.407

High

703791

XPO1
Exportin-1

1

2

High-throughput

0.407

High

703795

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

703797

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

High-throughput

0.407

High

703798

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

1

High-throughput

0.407

High

703799

CSE1
Importin alpha re-exporter

1

1

High-throughput

0.407

High

703814

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.407

High

703818

GEA2
ARF guanine-nucleotide exchange factor 2

1

2

High-throughput

0.407

High

703819

IMB4
Importin subunit beta-4

1

5

High-throughput

0.407

High

703820

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.407

High

703827

BNI1
Protein BNI1

1

1

High-throughput

0.407

High

703837

MSN5
Protein MSN5

1

2

High-throughput

0.407

High

703850

IMB1
Importin subunit beta-1

1

5

High-throughput

0.407

High

703843

YD541
Putative uncharacterized oxidoreductase YDR541C

1

0

High-throughput

0.282

High

703846

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

0

High-throughput

0.282

High

703854

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

0

High-throughput

0.282

High

703833

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

0

High-throughput

0.261

Low

703839

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

594237

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.249

Low

703790

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

703807

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

703835

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

703810

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.238

Low

703855

HSH49
Protein HSH49

1

0

High-throughput

0.238

Low

358138

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.232

Low

359167

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

High-throughput

0.232

Low

386605

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

394310

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

427167

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

439271

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.232

Low

453459

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

511748

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.232

Low

531264

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.232

Low

575403

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

613537

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.232

Low

661588

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.232

Low

703793

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

703794

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.232

Low

703796

PTM1
Membrane protein PTM1

1

0

High-throughput

0.232

Low

703800

BUD2
Inhibitory regulator protein BUD2/CLA2

1

0

High-throughput

0.232

Low

703803

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.232

Low

703823

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

703824

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.232

Low

703828

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

703836

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.232

Low

703847

DOP1
Protein DOP1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025