Protein: M3K6
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)

Gene: M3K6, MAP3K6
Organism: Homo sapiens
Interactions: 55
UniProt ID: O95382

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0006468 - protein phosphorylation
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335338

M3K5
Mitogen-activated protein kinase kinase kinase 5

5

18

Small-scale

0.924

High

335333

PKHO2
Pleckstrin homology domain-containing family O member 2

3

4

High-throughput

0.770

High

335312

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

19

High-throughput

0.737

High

335322

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

9

High-throughput

0.726

High

335325

H90B4
Putative heat shock protein HSP 90-beta 4

2

20

High-throughput

0.712

High

335326

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

335327

HS904
Putative heat shock protein HSP 90-alpha A4

2

20

High-throughput

0.712

High

225511

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

15

High-throughput

0.691

High

335306

MK04
Mitogen-activated protein kinase 4

1

20

High-throughput

0.691

High

335314

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

18

High-throughput

0.691

High

335315

ACTB
Actin, cytoplasmic 1

1

14

High-throughput

0.691

High

335318

ACTA
Actin, aortic smooth muscle

1

14

High-throughput

0.691

High

335346

TN13B
Tumor necrosis factor ligand superfamily member 13B

3

2

High-throughput

0.667

High

335316

1433G
14-3-3 protein gamma

3

20

Small-scale

0.662

High

335308

1433S
14-3-3 protein sigma

3

20

Small-scale

0.656

High

335320

1433F
14-3-3 protein eta

3

20

Small-scale

0.650

High

335297

RASH
GTPase HRas

1

20

Small-scale

0.647

High

74424

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

6

High-throughput

0.618

High

335323

CDC37
Hsp90 co-chaperone Cdc37

1

16

High-throughput

0.618

High

335298

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

335299

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

335317

1433E
14-3-3 protein epsilon

2

20

Small-scale

0.584

High

335321

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

8

High-throughput

0.574

High

335328

RN123
E3 ubiquitin-protein ligase RNF123

2

6

High-throughput

0.574

High

335341

LIMD1
LIM domain-containing protein 1

2

3

High-throughput

0.574

High

335343

PCDA4
Protocadherin alpha-4

2

2

High-throughput

0.574

High

335300

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.536

High

335303

S100P
Protein S100-P

1

20

High-throughput

0.536

High

335302

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.489

High

335305

SPB3
Serpin B3

1

3

High-throughput

0.489

High

335309

GDE
Glycogen debranching enzyme

1

1

High-throughput

0.489

High

335311

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.489

High

335313

PEX5
Peroxisomal targeting signal 1 receptor

1

9

High-throughput

0.489

High

335331

ASPM
Abnormal spindle-like microcephaly-associated protein

1

20

High-throughput

0.489

High

335332

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

335336

EFMT3
EEF1A lysine methyltransferase 3

1

8

High-throughput

0.489

High

335340

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.489

High

335344

PCDAC
Protocadherin alpha-12

1

2

High-throughput

0.489

High

335345

LIMC1
LIM and calponin homology domains-containing protein 1

1

16

High-throughput

0.489

High

335304

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

335307

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.479

High

335319

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

335347

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

2

High-throughput

0.479

High

335324

CL16A
Protein CLEC16A

1

3

High-throughput

0.437

High

335335

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.437

High

335342

FBW1B
F-box/WD repeat-containing protein 11

1

20

Small-scale

0.437

High

335301

SYT1
Synaptotagmin-1

1

3

High-throughput

0.407

High

335339

UBAC1
Ubiquitin-associated domain-containing protein 1

2

0

High-throughput

0.328

High

335296

DYR
Dihydrofolate reductase

1

0

High-throughput

0.279

Low

335310

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.279

Low

335330

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

335334

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

335337

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.279

Low

335329

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

191274

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025