Protein: PPCE
Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme)

Gene: PPCE, PREP
Organism: Homo sapiens
Interactions: 42
UniProt ID: P48147

Gene Ontology (top 5):
GO:0002003 - angiotensin maturation
GO:0004181 - metallocarboxypeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

870486

SGO2
Shugoshin 2

3

0

High-throughput

0.638

High

870490

RHPN1
Rhophilin-1

2

2

High-throughput

0.628

High

870492

FAN
Protein FAN

2

0

High-throughput

0.602

High

870501

KIF3A
Kinesin-like protein KIF3A

2

0

High-throughput

0.602

High

241038

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

408728

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

Small-scale

0.578

High

870496

MTG2
Mitochondrial ribosome-associated GTPase 2

2

2

High-throughput

0.574

High

325302

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.513

High

870477

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.513

High

870478

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

870479

DSCR6
Protein ripply3

1

0

High-throughput

0.513

High

870485

KR196
Keratin-associated protein 19-6

1

0

High-throughput

0.513

High

870488

LACC1
Purine nucleoside phosphorylase LACC1

1

0

High-throughput

0.513

High

870498

SUCO
SUN domain-containing ossification factor

1

0

High-throughput

0.513

High

791171

SYUA
Alpha-synuclein

1

0

Small-scale

0.504

High

798831

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.481

High

170008

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

379942

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

4

High-throughput

0.479

High

588158

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

694880

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

870480

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

870482

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.479

High

870483

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

870487

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

870491

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

870499

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

870502

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

870476

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

870484

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

870489

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

870494

TP4A1
Protein tyrosine phosphatase type IVA 1

1

0

High-throughput

0.458

High

870495

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

870497

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

870500

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

529317

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

639205

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

High-throughput

0.445

High

105544

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

411555

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

767654

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

870481

FADD
FAS-associated death domain protein

1

0

High-throughput

0.426

High

870493

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.426

High

616729

SDC1
Syndecan-1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025