Protein: TP4A1
Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)

Gene: TP4A1, PTP4A1
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q93096

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1372475

CNNM1
Metal transporter CNNM1

6

10

High-throughput

0.850

High

1242457

CNNM4
Metal transporter CNNM4

6

10

High-throughput

0.847

High

1337044

CNNM3
Metal transporter CNNM3

6

10

Small-scale

0.847

High

1372473

CNNM2
Metal transporter CNNM2

3

10

High-throughput

0.770

High

1091830

TP4A2
Protein tyrosine phosphatase type IVA 2

10

16

Small-scale

0.754

High

921554

PGTB2
Geranylgeranyl transferase type-2 subunit beta

4

4

High-throughput

0.630

High

907523

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

8

High-throughput

0.621

High

1372455

TP4A1
Protein tyrosine phosphatase type IVA 1

1

15

High-throughput

0.618

High

1372490

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

2

1

High-throughput

0.611

High

881732

FNTB
Protein farnesyltransferase subunit beta

3

4

High-throughput

0.609

High

1372485

TMED5
Transmembrane emp24 domain-containing protein 5

2

3

High-throughput

0.601

High

332328

ATE1
Arginyl-tRNA--protein transferase 1

2

0

High-throughput

0.576

High

1209479

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

High-throughput

0.571

High

1372457

LRC39
Leucine-rich repeat-containing protein 39

2

1

High-throughput

0.558

High

211010

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

High-throughput

0.554

High

969013

PRS8
26S proteasome regulatory subunit 8

1

4

High-throughput

0.554

High

1098083

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.554

High

1372461

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

4

High-throughput

0.554

High

530181

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.536

High

789943

FDFT
Squalene synthase

1

1

High-throughput

0.536

High

854207

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.536

High

881679

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

2

High-throughput

0.536

High

922478

CLH2
Clathrin heavy chain 2

1

6

High-throughput

0.536

High

1130906

PSF1
DNA replication complex GINS protein PSF1

1

1

High-throughput

0.536

High

1372465

NUD12
NAD-capped RNA hydrolase NUDT12

1

13

High-throughput

0.536

High

1372466

SLD5
DNA replication complex GINS protein SLD5

1

1

High-throughput

0.536

High

1372467

PSF3
DNA replication complex GINS protein PSF3

1

1

High-throughput

0.536

High

1372481

PSF2
DNA replication complex GINS protein PSF2

1

1

High-throughput

0.536

High

897548

BPL1
Biotin--protein ligase

1

0

High-throughput

0.530

High

605268

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

5

Small-scale

0.527

High

335289

TFIP8
Tumor necrosis factor alpha-induced protein 8

1

1

High-throughput

0.515

High

1118236

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

1372460

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

0

High-throughput

0.513

High

787505

GNL1
Guanine nucleotide-binding protein-like 1

1

4

Small-scale

0.508

High

1258532

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

Small-scale

0.508

High

422791

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

669280

PTAFR
Platelet-activating factor receptor

1

2

High-throughput

0.489

High

1228766

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

3

High-throughput

0.489

High

1281389

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

1

High-throughput

0.489

High

1372476

ARL15
ADP-ribosylation factor-like protein 15

1

9

High-throughput

0.489

High

1372487

BOLA1
BolA-like protein 1

1

1

High-throughput

0.489

High

271284

CPNE3
Copine-3

1

1

High-throughput

0.479

High

431210

LA
Lupus La protein

1

3

High-throughput

0.479

High

539220

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.479

High

589337

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

613126

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

619090

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

High-throughput

0.479

High

646907

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

658973

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

3

High-throughput

0.479

High

673925

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

703676

MK01
Mitogen-activated protein kinase 1

1

20

High-throughput

0.479

High

719165

MPIP1
M-phase inducer phosphatase 1

1

3

High-throughput

0.479

High

900072

FXR1
RNA-binding protein FXR1

1

5

High-throughput

0.479

High

938602

PSA
Puromycin-sensitive aminopeptidase

1

1

High-throughput

0.479

High

1087477

GRSF1
G-rich sequence factor 1

1

4

High-throughput

0.479

High

1095431

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

5

High-throughput

0.479

High

1129107

PLSI
Plastin-1

1

3

High-throughput

0.479

High

1157847

DDB1
DNA damage-binding protein 1

1

6

High-throughput

0.479

High

1158151

MK14
Mitogen-activated protein kinase 14

1

20

High-throughput

0.479

High

1334109

TXND5
Thioredoxin domain-containing protein 5

1

9

High-throughput

0.479

High

1334493

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1338312

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1372456

RL36L
Ribosomal protein eL42-like

1

2

High-throughput

0.479

High

1372458

NUD16
U8 snoRNA-decapping enzyme

1

1

High-throughput

0.479

High

1372462

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1372468

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

2

High-throughput

0.479

High

1372470

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

1372471

ATG5
Autophagy protein 5

1

2

High-throughput

0.479

High

1372478

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1372479

MRT4
mRNA turnover protein 4 homolog

1

2

High-throughput

0.479

High

1372484

PDIP2
Polymerase delta-interacting protein 2

1

5

High-throughput

0.479

High

1372486

RNF11
RING finger protein 11

1

3

Small-scale

0.479

High

1372488

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

1372489

COPG1
Coatomer subunit gamma-1

1

8

High-throughput

0.479

High

1372477

ZN212
Zinc finger protein 212

1

3

Small-scale

0.464

High

542804

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.458

High

870494

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.458

High

1270389

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

1372463

MACD1
ADP-ribose glycohydrolase MACROD1

1

0

High-throughput

0.458

High

1372480

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

154858

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

4

High-throughput

0.437

High

162112

ACOT8
Acyl-coenzyme A thioesterase 8

1

1

High-throughput

0.437

High

720788

PUR8
Adenylosuccinate lyase

1

2

High-throughput

0.437

High

768822

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

892486

GUAA
GMP synthase [glutamine-hydrolyzing]

1

1

High-throughput

0.437

High

1271657

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.437

High

1292962

AROS
Active regulator of SIRT1

1

3

High-throughput

0.437

High

1338793

FAD1
FAD synthase

1

3

High-throughput

0.437

High

1347027

G45IP
Large ribosomal subunit protein mL64

1

4

High-throughput

0.437

High

1372483

RT28
Small ribosomal subunit protein bS1m

1

2

High-throughput

0.437

High

1336115

NNRE
NAD(P)H-hydrate epimerase

1

0

High-throughput

0.426

High

281133

NDK6
Nucleoside diphosphate kinase 6

1

5

High-throughput

0.407

High

357966

CYB5
Cytochrome b5

1

1

High-throughput

0.407

High

976845

LCN6
Epididymal-specific lipocalin-6

1

1

High-throughput

0.407

High

1352145

EOLA1
Protein EOLA1

1

1

High-throughput

0.407

High

1372459

EOLA2
Protein EOLA2

1

1

High-throughput

0.407

High

1372469

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

1372474

ITM2C
Integral membrane protein 2C

1

2

High-throughput

0.407

High

569207

CD59
CD59 glycoprotein

1

0

High-throughput

0.279

Low

1200105

UNC50
Protein unc-50 homolog

1

0

High-throughput

0.279

Low

1251671

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1346847

OCC1
Overexpressed in colon carcinoma 1 protein

1

0

High-throughput

0.279

Low

914958

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.249

Low

1352881

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.249

Low

1370185

RL3L
Ribosomal protein uL3-like

1

0

High-throughput

0.249

Low

1372464

CMS1
Protein CMSS1

1

0

High-throughput

0.249

Low

1372482

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.249

Low

1372472

IL25
Interleukin-25

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025