Protein: LACC1
Purine nucleoside phosphorylase LACC1 (EC 2.4.2.1) (Adenosine deaminase LACC1) (EC 3.5.4.4) (Fatty acid metabolism-immunity nexus) (Guanosine phosphorylase LACC1) (Laccase domain-containing protein 1) (S-methyl-5'-thioadenosine phosphorylase LACC1) (EC 2.4.2.28)

Gene: LACC1
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q8IV20

Gene Ontology (top 5):
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002720 - positive regulation of cytokine production involved in immune response
GO:0004000 - adenosine deaminase activity
GO:0004731 - purine-nucleoside phosphorylase activity
GO:0005507 - copper ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1017001

H33
Histone H3.3

3

1

High-throughput

0.667

High

1208614

BRM1L
Breast cancer metastasis-suppressor 1-like protein

3

1

High-throughput

0.667

High

1308323

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

3

1

High-throughput

0.667

High

1308321

SIN3A
Paired amphipathic helix protein Sin3a

4

0

Small-scale

0.661

High

679370

DNJB2
DnaJ homolog subfamily B member 2

3

0

High-throughput

0.638

High

1162822

H2A2C
Histone H2A type 2-C

3

0

High-throughput

0.638

High

1195566

ARI4B
AT-rich interactive domain-containing protein 4B

3

0

High-throughput

0.638

High

1236020

HPHL1
Ferroxidase HEPHL1

3

0

High-throughput

0.638

High

1308319

ZBT10
Zinc finger and BTB domain-containing protein 10

3

0

High-throughput

0.638

High

1308322

TSNAX
Translin-associated protein X

3

0

High-throughput

0.638

High

1308326

OSER1
Oxidative stress-responsive serine-rich protein 1

3

0

High-throughput

0.638

High

1308330

GPTC8
G patch domain-containing protein 8

3

0

High-throughput

0.638

High

1308333

PKP3
Plakophilin-3

3

0

High-throughput

0.638

High

231499

ORC4
Origin recognition complex subunit 4

3

0

High-throughput

0.629

High

1308318

LRC15
Leucine-rich repeat-containing protein 15

3

1

High-throughput

0.609

High

567445

TCTP
Translationally-controlled tumor protein

2

0

High-throughput

0.602

High

988503

RAC1
Ras-related C3 botulinum toxin substrate 1

2

0

High-throughput

0.602

High

1308320

RHG07
Rho GTPase-activating protein 7

2

0

High-throughput

0.602

High

1050037

PLP2
Proteolipid protein 2

2

0

High-throughput

0.585

High

1216222

H37
Histone H3-7

2

1

High-throughput

0.552

High

484179

PGFRB
Platelet-derived growth factor receptor beta

1

0

High-throughput

0.513

High

582587

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

870488

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.513

High

881234

FAS
Fatty acid synthase

1

0

Small-scale

0.513

High

994287

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

High-throughput

0.458

High

1277845

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

95841

E7DVW5
Fatty acid binding protein 5

1

0

Small-scale

0.426

High

168286

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

Small-scale

0.426

High

282603

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

Small-scale

0.426

High

358736

LDHA
L-lactate dehydrogenase A chain

1

0

Small-scale

0.426

High

385931

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.426

High

617320

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

0

Small-scale

0.426

High

848793

MAGAA
Melanoma-associated antigen 10

1

0

High-throughput

0.426

High

849371

RANG
Ran-specific GTPase-activating protein

1

0

Small-scale

0.426

High

1100094

TIF1B
Transcription intermediary factor 1-beta

1

0

Small-scale

0.426

High

1136464

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

Small-scale

0.426

High

1157799

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.426

High

1308324

CLSPN
Claspin

1

0

Small-scale

0.426

High

1308327

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

0

Small-scale

0.426

High

75768

B3KWI4
cDNA FLJ43122 fis, clone CTONG3003737, highly similar to Leucine-rich repeat-containing protein 15

1

1

Small-scale

0.407

High

1204246

Q5EFE5
Anti-RhD monoclonal T125 gamma1 heavy chain

1

1

Small-scale

0.407

High

1236399

Q6N093
Uncharacterized protein DKFZp686I04196

1

1

Small-scale

0.407

High

787674

SPB5
Serpin B5

4

0

Small-scale

0.360

High

1098636

SBP1
Methanethiol oxidase

4

0

Small-scale

0.360

High

326733

DUS14
Dual specificity protein phosphatase 14

3

0

High-throughput

0.347

High

753924

CKS2
Cyclin-dependent kinases regulatory subunit 2

3

0

High-throughput

0.347

High

1226833

ATG9B
Autophagy-related protein 9B

3

0

High-throughput

0.347

High

1286432

DSG4
Desmoglein-4

3

0

High-throughput

0.347

High

1308317

ALMS1
Centrosome-associated protein ALMS1

3

0

Small-scale

0.339

High

1207475

CAHM4
Calcium homeostasis modulator protein 4

2

0

High-throughput

0.328

High

1286390

LYG2
Lysozyme g-like protein 2

2

0

High-throughput

0.328

High

1308334

SNX8
Sorting nexin-8

2

0

High-throughput

0.328

High

516687

VSIG8
V-set and immunoglobulin domain-containing protein 8

2

0

High-throughput

0.288

High

1308331

PLAK2
PALM2-AKAP2 fusion protein

2

0

High-throughput

0.288

High

276842

VATG1
V-type proton ATPase subunit G 1

1

0

High-throughput

0.279

Low

1308328

GBG12

1

0

High-throughput

0.279

Low

1308325

ANLN
Anillin

1

0

High-throughput

0.249

Low

62226

A4D1U5
Acylglycerol kinase, mitochondrial

1

0

Small-scale

0.232

Low

75841

B4DDF7
cDNA FLJ53296, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

Small-scale

0.232

Low

76282

B4DKR1
MICOS complex subunit MIC60

1

0

Small-scale

0.232

Low

85158

B7Z3V1
Sodium/potassium-transporting ATPase subunit alpha

1

0

Small-scale

0.232

Low

96934

E9PG19
F-BAR and double SH3 domains protein 2

1

0

Small-scale

0.232

Low

116762

I3L2N2
Dishevelled segment polarity protein 2

1

0

Small-scale

0.232

Low

117206

K7EIG1
Clustered mitochondria homolog

1

0

Small-scale

0.232

Low

117717

L0R5A1
Alternative protein CSF2RB

1

0

Small-scale

0.232

Low

457880

INVO
Involucrin

1

0

Small-scale

0.232

Low

553226

KCRB
Creatine kinase B-type

1

0

Small-scale

0.232

Low

592859

CBR1
Carbonyl reductase [NADPH] 1

1

0

Small-scale

0.232

Low

1232399

Q6FHQ0
RBBP7 protein

1

0

Small-scale

0.232

Low

1308316

SUGP1
SURP and G-patch domain-containing protein 1

1

0

Small-scale

0.232

Low

1308329

SCNBA
Sodium channel protein type 11 subunit alpha

1

0

Small-scale

0.232

Low

1308332

NISCH
Nischarin

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025