Protein: AACT
Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less]

Gene: AACT, SERPINA3
Organism: Homo sapiens
Interactions: 121
UniProt ID: P01011

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

126320

MATN2
Matrilin-2

1

2

High-throughput

0.691

High

344266

CATG
Cathepsin G

1

20

High-throughput

0.691

High

344317

NECT2
Nectin-2

1

1

High-throughput

0.691

High

344265

ELNE
Neutrophil elastase

1

20

Small-scale

0.647

High

344274

KLK2
Kallikrein-2

1

20

Small-scale

0.647

High

344349

KLK13
Kallikrein-13

1

20

Small-scale

0.647

High

344280

MPI
Mannose-6-phosphate isomerase

2

1

High-throughput

0.628

High

344294

ZIC1
Zinc finger protein ZIC 1

2

7

High-throughput

0.628

High

344326

CDK15
Cyclin-dependent kinase 15

2

6

High-throughput

0.628

High

344336

DDX31
ATP-dependent DNA helicase DDX31

2

5

High-throughput

0.628

High

344339

SHCAF
SIN3-HDAC complex-associated factor

2

2

High-throughput

0.628

High

341171

HPT
Haptoglobin

1

20

High-throughput

0.618

High

344137

A1AT
Alpha-1-antitrypsin

1

5

High-throughput

0.618

High

344283

GRAM
Granzyme M

1

20

Small-scale

0.618

High

344350

DD19B
ATP-dependent RNA helicase DDX19B

2

8

High-throughput

0.611

High

344312

GDPD1
Lysophospholipase D GDPD1

3

1

High-throughput

0.609

High

344332

PHAF1
Phagosome assembly factor 1

3

2

High-throughput

0.609

High

344323

SNX27
Sorting nexin-27

2

1

High-throughput

0.574

High

344342

TB22B
TBC1 domain family member 22B

2

6

High-throughput

0.574

High

344322

DNJC1
DnaJ homolog subfamily C member 1

1

0

Small-scale

0.561

High

344270

CFTR
Cystic fibrosis transmembrane conductance regulator

1

10

High-throughput

0.541

High

344275

LMNB1
Lamin-B1

1

2

High-throughput

0.541

High

125952

UPK1A
Uroplakin-1a

1

8

High-throughput

0.536

High

265289

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.536

High

274889

RENR
Renin receptor

1

6

High-throughput

0.536

High

324975

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

328076

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

329064

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

4

High-throughput

0.536

High

331682

NSD2
Histone-lysine N-methyltransferase NSD2

1

2

High-throughput

0.536

High

344268

SKI
Ski oncogene

1

2

High-throughput

0.536

High

344272

AATC
Aspartate aminotransferase, cytoplasmic

1

7

High-throughput

0.536

High

344276

CCNC
Cyclin-C

1

6

High-throughput

0.536

High

344279

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.536

High

344282

PCP4
Calmodulin regulator protein PCP4

1

3

High-throughput

0.536

High

344286

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.536

High

344289

GABPA
GA-binding protein alpha chain

1

7

High-throughput

0.536

High

344292

FSTL1
Follistatin-related protein 1

1

2

High-throughput

0.536

High

344296

ZN674
Zinc finger protein 674

1

2

High-throughput

0.536

High

344304

APTX
Aprataxin

1

3

High-throughput

0.536

High

344306

CIR1
Corepressor interacting with RBPJ 1

1

1

High-throughput

0.536

High

344330

EGFL8
Epidermal growth factor-like protein 8

1

2

High-throughput

0.536

High

344333

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.536

High

344337

COE2
Transcription factor COE2

1

4

High-throughput

0.536

High

344341

MBNL1
Muscleblind-like protein 1

1

5

High-throughput

0.536

High

344345

THA10
THAP domain-containing protein 10

1

1

High-throughput

0.536

High

344347

PHF11
PHD finger protein 11

1

8

High-throughput

0.536

High

344352

SSUH2
Protein SSUH2 homolog

1

7

High-throughput

0.536

High

344354

RN115
E3 ubiquitin-protein ligase RNF115

1

7

High-throughput

0.536

High

344263

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

344269

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

344284

CASP6
Caspase-6

1

6

High-throughput

0.515

High

344351

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

High-throughput

0.515

High

344313

NFAM1
NFAT activation molecule 1

1

0

High-throughput

0.513

High

344264

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.501

High

333617

ADH1B
All-trans-retinol dehydrogenase [NAD(+)] ADH1B

1

2

High-throughput

0.494

High

182994

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

215792

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

4

High-throughput

0.489

High

217690

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

1

High-throughput

0.489

High

239683

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.489

High

303615

OR2A4
Olfactory receptor 2A4

1

11

High-throughput

0.489

High

312688

CXB5
Gap junction beta-5 protein

1

1

High-throughput

0.489

High

344285

STX17
Syntaxin-17

1

9

High-throughput

0.489

High

344288

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

8

High-throughput

0.489

High

344297

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.489

High

344299

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.489

High

344300

TGO1
Transport and Golgi organization protein 1 homolog

1

8

High-throughput

0.489

High

344301

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

6

High-throughput

0.489

High

344302

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.489

High

344303

SFXN4
Sideroflexin-4

1

1

High-throughput

0.489

High

344305

MOGT3
2-acylglycerol O-acyltransferase 3

1

7

High-throughput

0.489

High

344309

ELOA2
Elongin-A2

1

2

High-throughput

0.489

High

344310

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

344311

PLD5
Inactive phospholipase D5

1

1

High-throughput

0.489

High

344314

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.489

High

344315

TRI41
E3 ubiquitin-protein ligase TRIM41

1

2

High-throughput

0.489

High

344321

SARAF
Store-operated calcium entry-associated regulatory factor

1

9

High-throughput

0.489

High

344324

F227B
Protein FAM227B

1

2

High-throughput

0.489

High

344325

FMNL2
Formin-like protein 2

1

1

High-throughput

0.489

High

344327

TEFM
Transcription elongation factor, mitochondrial

1

4

High-throughput

0.489

High

344329

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

8

High-throughput

0.489

High

344331

SH23A
SH2 domain-containing protein 3A

1

8

High-throughput

0.489

High

344335

ZDHC6
Palmitoyltransferase ZDHHC6

1

1

High-throughput

0.489

High

344340

TSSP
Thymus-specific serine protease

1

5

High-throughput

0.489

High

344343

KLH11
Kelch-like protein 11

1

5

High-throughput

0.489

High

344348

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

344273

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

5

High-throughput

0.481

High

344355

LAMC3
Laminin subunit gamma-3

1

1

High-throughput

0.481

High

168698

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

6

Small-scale

0.479

High

260424

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.479

High

336750

CERU
Ceruloplasmin

1

1

High-throughput

0.479

High

344257

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

High-throughput

0.479

High

344258

A1AG1
Alpha-1-acid glycoprotein 1

1

2

High-throughput

0.479

High

344259

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.479

High

344260

TRFE
Serotransferrin

1

2

High-throughput

0.479

High

344261

HEMO
Hemopexin

1

2

High-throughput

0.479

High

344262

STAT
Statherin

1

1

High-throughput

0.479

High

344267

CLUS
Clusterin

1

1

High-throughput

0.479

High

344277

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

344278

LCN1
Lipocalin-1

1

2

High-throughput

0.479

High

344287

HBB
Hemoglobin subunit beta

1

2

High-throughput

0.479

High

344293

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.479

High

344295

PROL4
Proline-rich protein 4

1

1

High-throughput

0.479

High

344319

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.479

High

344328

RANB9
Ran-binding protein 9

1

5

High-throughput

0.479

High

344334

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

344353

SHLB1
Endophilin-B1

1

2

High-throughput

0.470

High

344271

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.458

High

344307

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

344338

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.458

High

257246

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

1

Small-scale

0.457

High

344290

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

344281

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.426

High

344316

SGCD
Delta-sarcoglycan

1

0

High-throughput

0.282

High

344291

TWF1
Twinfilin-1

1

0

High-throughput

0.279

Low

344298

T176B
Transmembrane protein 176B

1

0

High-throughput

0.279

Low

344308

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.279

Low

344318

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

0

High-throughput

0.279

Low

344320

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.268

Low

344346

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.268

Low

179386

MRP5
ATP-binding cassette sub-family C member 5

1

0

High-throughput

0.251

Low

344344

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024