Protein: VGLL4
Transcription cofactor vestigial-like protein 4 (Vgl-4)

Gene: VGLL4
Organism: Homo sapiens
Interactions: 33
UniProt ID: Q14135

Gene Ontology (top 5):
GO:0001223 - transcription coactivator binding
GO:0005634 - nucleus
GO:0030178 - negative regulation of Wnt signaling pathway
GO:0030308 - negative regulation of cell growth
GO:0035331 - negative regulation of hippo signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121005

TEAD4
Transcriptional enhancer factor TEF-3

6

4

Small-scale

0.950

High

703135

TEAD1
Transcriptional enhancer factor TEF-1

5

4

Small-scale

0.930

High

1121014

TEAD3
Transcriptional enhancer factor TEF-5

5

4

High-throughput

0.828

High

1121006

TEAD2
Transcriptional enhancer factor TEF-4

2

4

High-throughput

0.783

High

1121011

I2BP2
Interferon regulatory factor 2-binding protein 2

5

2

Small-scale

0.719

High

1121012

I2BP1
Interferon regulatory factor 2-binding protein 1

4

2

High-throughput

0.691

High

1121016

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

4

2

High-throughput

0.691

High

907423

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

3

0

Small-scale

0.628

High

1121007

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

2

High-throughput

0.550

High

1121019

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.549

High

862122

YAP1
Transcriptional coactivator YAP1

2

0

Small-scale

0.528

High

1025342

CDK6
Cyclin-dependent kinase 6

1

0

Small-scale

0.527

High

920440

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.513

High

718890

CCND3
G1/S-specific cyclin-D3

1

0

High-throughput

0.513

High

1121017

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1121010

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.489

High

1121021

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

2

High-throughput

0.489

High

142989

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

473978

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

1087733

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1121004

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.479

High

1034679

MEF2A
Myocyte-specific enhancer factor 2A

1

0

Small-scale

0.460

High

986418

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1113074

CUL3
Cullin-3

1

0

High-throughput

0.458

High

140261

SDCB1
Syntenin-1

1

0

High-throughput

0.426

High

1121015

ZY11B
Protein zyg-11 homolog B

1

0

High-throughput

0.279

Low

892458

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

High-throughput

0.232

Low

999349

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.232

Low

1121008

CEA21
Cell adhesion molecule CEACAM21

1

0

High-throughput

0.232

Low

1121009

H1BP3
HCLS1-binding protein 3

1

0

High-throughput

0.232

Low

1121013

KCD17
BTB/POZ domain-containing protein KCTD17

1

0

High-throughput

0.232

Low

1121018

XPP1
Xaa-Pro aminopeptidase 1

1

0

High-throughput

0.232

Low

1121020

PEF1
Peflin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025