Protein: I2BP1
Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1)

Gene: I2BP1, IRF2BP1
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q8IU81

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571619

IRF2
Interferon regulatory factor 2

5

3

Small-scale

0.728

High

1279284

I2BP2
Interferon regulatory factor 2-binding protein 2

5

9

Small-scale

0.712

High

584117

FOSL2
Fos-related antigen 2

4

4

High-throughput

0.691

High

1121012

VGLL4
Transcription cofactor vestigial-like protein 4

4

2

High-throughput

0.691

High

1306957

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

4

7

Small-scale

0.691

High

1306951

CCNL2
Cyclin-L2

3

1

High-throughput

0.667

High

1306940

DCP1B
mRNA-decapping enzyme 1B

2

0

High-throughput

0.602

High

1122281

SCRIB
Protein scribble homolog

2

2

High-throughput

0.601

High

1306945

JDP2
Jun dimerization protein 2

1

4

Small-scale

0.597

High

143101

NFIB
Nuclear factor 1 B-type

2

11

High-throughput

0.584

High

1133513

NFIX
Nuclear factor 1 X-type

2

11

High-throughput

0.584

High

158466

RFXK
DNA-binding protein RFXANK

1

1

High-throughput

0.536

High

854149

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

872497

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.536

High

1306944

IASPP
RelA-associated inhibitor

1

1

High-throughput

0.536

High

887006

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.527

High

74538

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

1306947

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1306953

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

583578

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

Small-scale

0.505

High

347152

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.489

High

1153975

SMAD1
Mothers against decapentaplegic homolog 1

1

0

High-throughput

0.486

High

1028130

IRF9
Interferon regulatory factor 9

1

3

Small-scale

0.481

High

995987

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

0

High-throughput

0.480

High

260148

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

323473

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

378505

IL1A
Interleukin-1 alpha

1

1

Small-scale

0.479

High

404192

GCR
Glucocorticoid receptor

1

10

High-throughput

0.479

High

474109

NFIC
Nuclear factor 1 C-type

1

11

High-throughput

0.479

High

606896

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

703165

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

714245

PML
Protein PML

1

1

High-throughput

0.479

High

725281

TLX1
T-cell leukemia homeobox protein 1

1

1

High-throughput

0.479

High

776216

SOX6
Transcription factor SOX-6

1

9

High-throughput

0.479

High

833987

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

High-throughput

0.479

High

837064

ELK3
ETS domain-containing protein Elk-3

1

1

High-throughput

0.479

High

851782

NKX21
Homeobox protein Nkx-2.1

1

5

High-throughput

0.479

High

938473

PAX9
Paired box protein Pax-9

1

2

High-throughput

0.479

High

944697

KLF3
Krueppel-like factor 3

1

4

High-throughput

0.479

High

1056625

PAX8
Paired box protein Pax-8

1

2

High-throughput

0.479

High

1087852

NFIA
Nuclear factor 1 A-type

1

11

High-throughput

0.479

High

1095091

KLF10
Krueppel-like factor 10

1

2

High-throughput

0.479

High

1106351

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

2

High-throughput

0.479

High

1113611

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1306939

I2BP1
Interferon regulatory factor 2-binding protein 1

1

7

Small-scale

0.479

High

1306941

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1306943

SP7
Transcription factor Sp7

1

4

High-throughput

0.479

High

1306946

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1306950

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

1306960

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1306961

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

934827

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

946159

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.458

High

1026453

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1185196

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.458

High

1306959

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.458

High

412211

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

1306948

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

High-throughput

0.437

High

1306958

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

231600

PRKY
Putative serine/threonine-protein kinase PRKY

1

2

High-throughput

0.407

High

1306942

LRC20
Leucine-rich repeat-containing protein 20

1

3

High-throughput

0.407

High

1144775

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

0

High-throughput

0.347

High

1306956

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

0

High-throughput

0.282

High

231397

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.279

Low

298197

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

1306952

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1306955

DNAI2
Dynein axonemal intermediate chain 2

1

0

High-throughput

0.279

Low

272299

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

273552

DJC13
DnaJ homolog subfamily C member 13

1

0

High-throughput

0.249

Low

719638

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

0

High-throughput

0.249

Low

1154209

TBCE
Tubulin-specific chaperone E

1

0

High-throughput

0.249

Low

1219101

FYB2
FYN-binding protein 2

1

0

High-throughput

0.249

Low

1198997

KLH12
Kelch-like protein 12

1

0

High-throughput

0.232

Low

1306949

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.232

Low

1306954

RAB34
Ras-related protein Rab-34

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025