Protein: OAT
Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]

Gene: OAT
Organism: Homo sapiens
Interactions: 174
UniProt ID: P04181

Gene Ontology (top 5):
GO:0004587 - ornithine aminotransferase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

405221

OAT
Ornithine aminotransferase, mitochondrial

1

6

High-throughput

0.618

High

240457

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

279610

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

405344

ANLN
Anillin

2

0

High-throughput

0.559

High

405236

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.536

High

405270

KC1G2
Casein kinase I isoform gamma-2

1

2

High-throughput

0.536

High

405277

DMWD
Dystrophia myotonica WD repeat-containing protein

1

1

High-throughput

0.536

High

405311

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.518

High

405322

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

405254

CCNF
Cyclin-F

1

1

High-throughput

0.515

High

405255

5HT2B
5-hydroxytryptamine receptor 2B

1

1

High-throughput

0.515

High

405224

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

213765

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

369001

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

370891

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.513

High

405231

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

405248

MYH9
Myosin-9

1

0

High-throughput

0.513

High

405252

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

405260

ANX11
Annexin A11

1

0

High-throughput

0.513

High

405272

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.513

High

405274

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

405282

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

405287

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

405289

MYLK
Myosin light chain kinase, smooth muscle

1

0

High-throughput

0.513

High

405291

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

405302

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

405325

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

405348

UBQL4
Ubiquilin-4

1

7

High-throughput

0.508

High

405261

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.493

High

209429

SERA
D-3-phosphoglycerate dehydrogenase

1

2

High-throughput

0.489

High

405275

CALD1
Caldesmon

1

1

High-throughput

0.489

High

405318

FAF2
FAS-associated factor 2

1

1

High-throughput

0.489

High

352661

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

185341

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

277310

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.479

High

281854

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

348307

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

349727

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

362566

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

405222

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

405230

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

405234

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

405238

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

405239

NELFE
Negative elongation factor E

1

1

High-throughput

0.479

High

405241

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

405242

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

405250

BASI
Basigin

1

1

High-throughput

0.479

High

405258

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

405265

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

405268

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

405269

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

4

Small-scale

0.479

High

405278

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

405281

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

405284

CUL3
Cullin-3

1

1

High-throughput

0.479

High

405285

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

405292

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.479

High

405294

SMU1
WD40 repeat-containing protein SMU1

1

2

High-throughput

0.479

High

405300

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

405319

OPTN
Optineurin

1

1

High-throughput

0.479

High

405326

SNAG
Gamma-soluble NSF attachment protein

1

1

High-throughput

0.479

High

405330

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

405333

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

405338

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

405339

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

405353

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

405354

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

405355

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

405356

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

405357

FAF1
FAS-associated factor 1

1

1

High-throughput

0.479

High

405358

NSF1C
NSFL1 cofactor p47

1

1

Small-scale

0.479

High

405360

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

405366

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

876

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.464

High

61395

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

125135

LEG9
Galectin-9

1

0

High-throughput

0.458

High

239004

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.458

High

257299

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

293033

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

345242

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

405229

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

405232

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

405237

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

405243

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

405246

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

405247

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

405251

FUS
RNA-binding protein FUS

1

0

High-throughput

0.458

High

405253

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

405256

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

405257

IF2M
Translation initiation factor IF-2, mitochondrial

1

0

High-throughput

0.458

High

405259

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

405262

EPIPL
Epiplakin

1

0

High-throughput

0.458

High

405263

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

405264

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

405267

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

405271

CCNA1
Cyclin-A1

1

0

High-throughput

0.458

High

405273

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

405276

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

405279

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

405280

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

405283

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

405286

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

405288

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

405290

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

405293

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.458

High

405296

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

405298

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

405304

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

405305

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

405306

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

405308

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

405313

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

405314

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

405317

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

405320

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

405323

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

405324

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

405327

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.458

High

405328

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

405329

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

405331

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

405332

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

405334

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

405335

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

405337

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

405340

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

405341

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

405342

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

405345

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

405346

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

405351

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

405362

FND3A
Fibronectin type-III domain-containing protein 3A

1

0

High-throughput

0.458

High

405363

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.458

High

405364

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

405365

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

405225

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

405233

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

405240

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.445

High

405297

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

405299

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

405350

SPHK1
Sphingosine kinase 1

1

1

Small-scale

0.445

High

405347

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

254501

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.437

High

405226

INSR
Insulin receptor

1

1

High-throughput

0.437

High

405227

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.437

High

405228

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

2

High-throughput

0.437

High

405244

UFO
Tyrosine-protein kinase receptor UFO

1

2

High-throughput

0.437

High

405295

ANR55
Ankyrin repeat domain-containing protein 55

1

1

High-throughput

0.437

High

405309

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

405352

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

1

High-throughput

0.437

High

405235

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

405245

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

405310

THEM5
Acyl-coenzyme A thioesterase THEM5

1

0

High-throughput

0.426

High

405312

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

405321

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

104088

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

405349

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.407

High

405316

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.282

High

184103

RER1
Protein RER1

1

0

High-throughput

0.279

Low

405249

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

405303

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

405315

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.279

Low

405343

RTN4
Reticulon-4

1

0

High-throughput

0.279

Low

273805

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.269

Low

290829

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.249

Low

379829

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

405223

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

405266

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

262196

SCN2B
Sodium channel regulatory subunit beta-2

1

0

High-throughput

0.232

Low

405301

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.232

Low

405307

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.232

Low

405336

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

High-throughput

0.232

Low

405359

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low

405361

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025