Protein: EPHB4
Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)

Gene: EPHB4
Organism: Homo sapiens
Interactions: 133
UniProt ID: P54760

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0003007 - heart morphogenesis
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005003 - ephrin receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

856509

EFNB2
Ephrin-B2

5

20

Small-scale

0.932

High

533134

HLAE
HLA class I histocompatibility antigen, alpha chain E

3

7

High-throughput

0.861

High

872546

LRC33
Transforming growth factor beta activator LRRC33

2

13

High-throughput

0.811

High

354686

DRA
HLA class II histocompatibility antigen, DR alpha chain

2

12

High-throughput

0.789

High

872521

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

59742

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

10

High-throughput

0.726

High

872564

LRIQ1
Leucine-rich repeat and IQ domain-containing protein 1

2

20

High-throughput

0.726

High

872535

EPHA7
Ephrin type-A receptor 7

1

18

High-throughput

0.715

High

353030

EPO
Erythropoietin

1

0

Small-scale

0.708

High

434165

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.691

High

532918

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.691

High

557076

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.691

High

644550

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

10

High-throughput

0.691

High

685227

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

8

High-throughput

0.691

High

713775

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.691

High

855286

STAT2
Signal transducer and activator of transcription 2

1

11

High-throughput

0.691

High

872417

EPHA5
Ephrin type-A receptor 5

1

16

High-throughput

0.691

High

872531

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

12

High-throughput

0.691

High

872581

PAR6A
Partitioning defective 6 homolog alpha

1

9

High-throughput

0.691

High

872587

EPHA6
Ephrin type-A receptor 6

1

18

High-throughput

0.691

High

872591

CLC4A
C-type lectin domain family 4 member A

1

8

High-throughput

0.691

High

872524

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

3

1

High-throughput

0.667

High

158919

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.656

High

665384

EPHA3
Ephrin type-A receptor 3

1

18

High-throughput

0.646

High

872511

EPHB1
Ephrin type-B receptor 1

1

19

High-throughput

0.646

High

439793

NEP
Neprilysin

2

2

High-throughput

0.628

High

872553

I17RC
Interleukin-17 receptor C

2

2

High-throughput

0.628

High

872557

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

1

High-throughput

0.628

High

872562

MRAP2
Melanocortin-2 receptor accessory protein 2

2

2

High-throughput

0.628

High

872586

P2RX2
P2X purinoceptor 2

2

1

High-throughput

0.628

High

872601

PCDG5
Protocadherin gamma-A5

2

8

High-throughput

0.628

High

872603

PCDC2
Protocadherin alpha-C2

2

6

High-throughput

0.628

High

872538

CL12B
C-type lectin domain family 12 member B

1

6

High-throughput

0.618

High

120364

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

171296

EPHB6
Ephrin type-B receptor 6

1

17

Small-scale

0.618

High

350002

RASK
GTPase KRas

1

20

High-throughput

0.618

High

436224

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

545286

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

564462

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

595984

EFNA1
Ephrin-A1

1

20

High-throughput

0.618

High

789048

ABL2
Tyrosine-protein kinase ABL2

1

20

High-throughput

0.618

High

852414

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

872515

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

872516

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

872517

RAB2A
Ras-related protein Rab-2A

1

13

High-throughput

0.618

High

872518

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

872519

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

872522

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

872525

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

872527

KMT2A
Histone-lysine N-methyltransferase 2A

1

3

High-throughput

0.618

High

872534

RAB35
Ras-related protein Rab-35

1

13

High-throughput

0.618

High

872536

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

872544

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

872558

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

872575

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

872578

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

872567

ADPGK
ADP-dependent glucokinase

2

0

High-throughput

0.602

High

338184

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.575

High

872513

TMPS3
Transmembrane protease serine 3

2

17

High-throughput

0.574

High

872530

SG2A2
Mammaglobin-A

2

1

High-throughput

0.574

High

872576

MANS1
MANSC domain-containing protein 1

2

1

High-throughput

0.574

High

872532

PWP1
Periodic tryptophan protein 1 homolog

1

10

High-throughput

0.553

High

872543

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.553

High

872577

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.553

High

409508

HEPS
Serine protease hepsin

1

17

High-throughput

0.536

High

814598

V1BR
Vasopressin V1b receptor

1

2

High-throughput

0.536

High

872512

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

3

High-throughput

0.536

High

872537

CDC37
Hsp90 co-chaperone Cdc37

1

18

High-throughput

0.536

High

872555

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

2

High-throughput

0.536

High

872561

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

872570

TMPSD
Transmembrane protease serine 13

1

18

High-throughput

0.536

High

872579

CRLF2
Cytokine receptor-like factor 2

1

10

High-throughput

0.536

High

872590

FBX2
F-box only protein 2

1

7

High-throughput

0.536

High

872592

PCDAC
Protocadherin alpha-12

1

6

High-throughput

0.536

High

872593

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

5

High-throughput

0.536

High

872598

PCDB3
Protocadherin beta-3

1

7

High-throughput

0.536

High

872599

PCDG7
Protocadherin gamma-A7

1

8

High-throughput

0.536

High

872600

PCDG6
Protocadherin gamma-A6

1

8

High-throughput

0.536

High

872602

PCDA8
Protocadherin alpha-8

1

6

High-throughput

0.536

High

872605

ST14
Suppressor of tumorigenicity 14 protein

1

17

High-throughput

0.536

High

872606

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

486241

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.513

High

872549

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.513

High

872559

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

872565

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.513

High

394402

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.501

High

872596

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

814745

RL29
Large ribosomal subunit protein eL29

1

1

High-throughput

0.500

High

872572

MAGT1
Magnesium transporter protein 1

1

1

High-throughput

0.500

High

872594

VDAC3
Voltage-dependent anion-selective channel protein 3

1

1

High-throughput

0.500

High

269300

SG2A1
Mammaglobin-B

1

1

High-throughput

0.489

High

872541

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.489

High

872548

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

872554

RN149
E3 ubiquitin-protein ligase RNF149

1

3

High-throughput

0.489

High

872568

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

1

8

High-throughput

0.489

High

872580

SDF2L
Stromal cell-derived factor 2-like protein 1

1

5

High-throughput

0.489

High

872595

SL9A8
Sodium/hydrogen exchanger 8

1

2

High-throughput

0.489

High

205215

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

853217

IMA1
Importin subunit alpha-1

1

1

Small-scale

0.479

High

872520

ARF6
ADP-ribosylation factor 6

1

13

High-throughput

0.479

High

872526

CAV1
Caveolin-1

1

8

High-throughput

0.479

High

872528

CKAP4
Cytoskeleton-associated protein 4

1

13

High-throughput

0.479

High

872529

KLC1
Kinesin light chain 1

1

2

High-throughput

0.479

High

872533

EI2BA
Translation initiation factor eIF2B subunit alpha

1

4

High-throughput

0.479

High

872542

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

872547

DHX37
Probable ATP-dependent RNA helicase DHX37

1

4

High-throughput

0.479

High

872551

PCD20
Protocadherin-20

1

8

Small-scale

0.479

High

872556

DDX54
ATP-dependent RNA helicase DDX54

1

10

High-throughput

0.479

High

872560

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.479

High

872571

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

High-throughput

0.479

High

872574

DNJC5
DnaJ homolog subfamily C member 5

1

13

High-throughput

0.479

High

872582

TMPS4
Transmembrane protease serine 4

1

17

High-throughput

0.479

High

872588

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

5

High-throughput

0.479

High

559618

H12
Histone H1.2

1

2

High-throughput

0.470

High

836697

DNLI3
DNA ligase 3

1

0

High-throughput

0.458

High

872566

QRFPR
Pyroglutamylated RF-amide peptide receptor

1

0

Small-scale

0.458

High

872514

CD81
CD81 antigen

1

5

High-throughput

0.445

High

401697

JUN
Transcription factor Jun

1

1

High-throughput

0.437

High

872523

TBA1B
Tubulin alpha-1B chain

1

12

High-throughput

0.437

High

872539

SE1L2
Protein sel-1 homolog 2

1

4

High-throughput

0.437

High

872545

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

872552

KRI1
Protein KRI1 homolog

1

9

High-throughput

0.437

High

872569

REPI1
Replication initiator 1

1

5

High-throughput

0.437

High

872573

CCD68
Coiled-coil domain-containing protein 68

1

1

Small-scale

0.437

High

872583

RBM28
RNA-binding protein 28

1

11

High-throughput

0.437

High

872584

USE1
Vesicle transport protein USE1

1

2

High-throughput

0.437

High

872589

LEF1
Lymphoid enhancer-binding factor 1

1

2

Small-scale

0.437

High

872597

CHTOP
Chromatin target of PRMT1 protein

1

3

High-throughput

0.437

High

872604

SRPRB
Signal recognition particle receptor subunit beta

1

20

High-throughput

0.437

High

872563

TECT2
Tectonic-2

2

0

High-throughput

0.328

High

872540

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.249

Low

872550

GLT16
Polypeptide N-acetylgalactosaminyltransferase 16

1

0

Small-scale

0.249

Low

872585

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024