Protein: TMM74
Transmembrane protein 74

Gene: TMM74, TMEM74
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q96NL1

Gene Ontology (top 5):
GO:0000421 - autophagosome membrane
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0016236 - macroautophagy
GO:0031410 - cytoplasmic vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1205533

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

0

High-throughput

0.580

High

1358462

CANT1
Soluble calcium-activated nucleotidase 1

2

0

High-throughput

0.576

High

1399078

MAN1
Inner nuclear membrane protein Man1

2

1

High-throughput

0.549

High

135981

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

2

High-throughput

0.536

High

168890

PLD2
Phospholipase D2

1

1

High-throughput

0.536

High

226173

STX6
Syntaxin-6

1

3

High-throughput

0.536

High

692119

MARK3
MAP/microtubule affinity-regulating kinase 3

1

1

High-throughput

0.536

High

839072

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

High-throughput

0.536

High

839171

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

2

High-throughput

0.536

High

877207

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.536

High

1103789

PLD1
Phospholipase D1

1

1

High-throughput

0.536

High

1139027

SNX17
Sorting nexin-17

1

1

High-throughput

0.536

High

1218253

F1711
Protein FAM171A1

1

1

High-throughput

0.536

High

1270499

MARK2
Serine/threonine-protein kinase MARK2

1

1

High-throughput

0.536

High

1295538

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

High-throughput

0.536

High

1383302

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

1

High-throughput

0.536

High

1383731

MIB2
E3 ubiquitin-protein ligase MIB2

1

2

High-throughput

0.536

High

1399071

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

1

High-throughput

0.536

High

1399076

STX8
Syntaxin-8

1

3

High-throughput

0.536

High

213337

ADCY6
Adenylate cyclase type 6

1

0

High-throughput

0.513

High

213999

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

270676

ATP9A
Probable phospholipid-transporting ATPase IIA

1

0

High-throughput

0.513

High

291121

UTP20
Small subunit processome component 20 homolog

1

0

High-throughput

0.513

High

536285

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.513

High

560993

GP1BB
Platelet glycoprotein Ib beta chain

1

0

High-throughput

0.513

High

582192

INGR1
Interferon gamma receptor 1

1

0

High-throughput

0.513

High

732676

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

895364

S26A2
Sulfate transporter

1

0

High-throughput

0.513

High

935696

MFAP3
Microfibril-associated glycoprotein 3

1

0

High-throughput

0.513

High

1055348

APLP2
Amyloid beta precursor like protein 2

1

0

High-throughput

0.513

High

1086553

TROP
Trophinin

1

0

High-throughput

0.513

High

1128803

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.513

High

1206756

RRP12
RRP12-like protein

1

0

High-throughput

0.513

High

1278309

LRP10
Low-density lipoprotein receptor-related protein 10

1

0

High-throughput

0.513

High

1309331

ARL17
ADP-ribosylation factor-like protein 17

1

0

High-throughput

0.513

High

1346758

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.513

High

1399051

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.513

High

1399054

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1399060

PCDH9
Protocadherin-9

1

0

High-throughput

0.513

High

1399061

IL1AP
Interleukin-1 receptor accessory protein

1

0

High-throughput

0.513

High

1399062

AT132
Polyamine-transporting ATPase 13A2

1

0

High-throughput

0.513

High

1399066

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

High-throughput

0.513

High

1399068

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

0

High-throughput

0.513

High

1399070

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.513

High

1399082

S4A7
Sodium bicarbonate cotransporter 3

1

0

High-throughput

0.513

High

71355

F1712
Protein FAM171A2

1

1

High-throughput

0.489

High

180019

BET1
BET1 homolog

1

3

High-throughput

0.489

High

249891

STX10
Syntaxin-10

1

3

High-throughput

0.489

High

885874

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.489

High

909142

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.489

High

1144866

RABE1
Rab GTPase-binding effector protein 1

1

1

High-throughput

0.489

High

1335152

LEMD2
LEM domain-containing protein 2

1

1

High-throughput

0.489

High

1396768

SNX27
Sorting nexin-27

1

1

High-throughput

0.489

High

1399046

NEK1
Serine/threonine-protein kinase Nek1

1

3

High-throughput

0.489

High

1399059

RABE2
Rab GTPase-binding effector protein 2

1

1

High-throughput

0.489

High

1399064

ZDH18
Palmitoyltransferase ZDHHC18

1

1

High-throughput

0.489

High

1399073

RABX5
Rab5 GDP/GTP exchange factor

1

1

High-throughput

0.489

High

1399079

ZDHC9
Palmitoyltransferase ZDHHC9

1

1

High-throughput

0.489

High

255172

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

Small-scale

0.458

High

1227287

A16L1
Autophagy-related protein 16-1

1

0

Small-scale

0.458

High

1399044

ANR27
Ankyrin repeat domain-containing protein 27

1

1

High-throughput

0.445

High

216326

MGA
Maltase-glucoamylase

1

0

High-throughput

0.426

High

908042

VAMP7
Vesicle-associated membrane protein 7

1

0

High-throughput

0.426

High

1233424

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.426

High

1399048

OSMR
Oncostatin-M-specific receptor subunit beta

1

0

High-throughput

0.426

High

1399069

TEN3
Teneurin-3

1

0

High-throughput

0.426

High

1392143

SREC2
Scavenger receptor class F member 2

1

1

High-throughput

0.407

High

1109022

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

1229445

TMM42
Transmembrane protein 42

2

0

High-throughput

0.316

High

1399058

LIME1
Lck-interacting transmembrane adapter 1

2

0

High-throughput

0.316

High

1208057

CYTSB
Cytospin-B

2

0

High-throughput

0.313

High

1240396

M18BP
Mis18-binding protein 1

2

0

High-throughput

0.313

High

1242490

NFRKB
Nuclear factor related to kappa-B-binding protein

2

0

High-throughput

0.313

High

1247622

SAMD1
Sterile alpha motif domain-containing protein 1

2

0

High-throughput

0.313

High

1332755

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

2

0

High-throughput

0.313

High

1379868

FATE1
Fetal and adult testis-expressed transcript protein

1

0

High-throughput

0.299

High

62154

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

0

High-throughput

0.279

Low

136537

GOLI4
Golgi integral membrane protein 4

1

0

High-throughput

0.279

Low

209811

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.279

Low

272395

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.279

Low

290259

TM1L1
TOM1-like protein 1

1

0

High-throughput

0.279

Low

331914

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.279

Low

338935

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.279

Low

547930

PERE
Eosinophil peroxidase

1

0

High-throughput

0.279

Low

946187

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.279

Low

1013496

LSM11
U7 snRNA-associated Sm-like protein LSm11

1

0

High-throughput

0.279

Low

1025631

CDK17
Cyclin-dependent kinase 17

1

0

High-throughput

0.279

Low

1048273

HGFA
Hepatocyte growth factor activator serine protease

1

0

High-throughput

0.279

Low

1063545

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.279

Low

1097869

STX5
Syntaxin-5

1

0

High-throughput

0.279

Low

1132317

GOGB1
Golgin subfamily B member 1

1

0

High-throughput

0.279

Low

1140132

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.279

Low

1140712

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.279

Low

1141599

OZF
Zinc finger protein OZF

1

0

High-throughput

0.279

Low

1153092

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.279

Low

1206341

WDR44
WD repeat-containing protein 44

1

0

High-throughput

0.279

Low

1206956

CEP78
Centrosomal protein of 78 kDa

1

0

High-throughput

0.279

Low

1210736

ZMYM1
Zinc finger MYM-type protein 1

1

0

High-throughput

0.279

Low

1218163

CAHD1
VWFA and cache domain-containing protein 1

1

0

High-throughput

0.279

Low

1239141

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.279

Low

1272249

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.279

Low

1291561

HOOK3
Protein Hook homolog 3

1

0

High-throughput

0.279

Low

1293036

RLGPB
Ral GTPase-activating protein subunit beta

1

0

High-throughput

0.279

Low

1310111

MGAP
MAX gene-associated protein

1

0

High-throughput

0.279

Low

1313121

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.279

Low

1322503

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

1327881

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

1

0

High-throughput

0.279

Low

1334516

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.279

Low

1356488

F216A
Protein FAM216A

1

0

High-throughput

0.279

Low

1357824

S35F5
Solute carrier family 35 member F5

1

0

High-throughput

0.279

Low

1359533

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

1389064

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.279

Low

1395588

FACR2
Fatty acyl-CoA reductase 2

1

0

High-throughput

0.279

Low

1396697

LLR1
Leucine-rich repeat protein 1

1

0

High-throughput

0.279

Low

1399045

RBM14
RNA-binding protein 14

1

0

High-throughput

0.279

Low

1399047

SEC62
Translocation protein SEC62

1

0

High-throughput

0.279

Low

1399050

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.279

Low

1399052

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.279

Low

1399055

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.279

Low

1399056

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

1399057

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.279

Low

1399063

CHST7
Carbohydrate sulfotransferase 7

1

0

High-throughput

0.279

Low

1399065

INT7
Integrator complex subunit 7

1

0

High-throughput

0.279

Low

1399067

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.279

Low

1399072

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.279

Low

1399074

KDIS
Kinase D-interacting substrate of 220 kDa

1

0

High-throughput

0.279

Low

1399077

EXOG
Nuclease EXOG, mitochondrial

1

0

High-throughput

0.279

Low

692783

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.269

Low

386121

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

1399080

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.251

Low

1276277

ATG9A
Autophagy-related protein 9A

1

0

Small-scale

0.249

Low

1352423

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

0

High-throughput

0.232

Low

1393149

PRR11
Proline-rich protein 11

1

0

High-throughput

0.232

Low

1399049

MXRA8
Matrix remodeling-associated protein 8

1

0

High-throughput

0.232

Low

1399053

RAB34
Ras-related protein Rab-34

1

0

High-throughput

0.232

Low

1399075

YETS2
YEATS domain-containing protein 2

1

0

High-throughput

0.232

Low

1399081

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025