Protein: ZZZ3
ZZ-type zinc finger-containing protein 3

Gene: ZZZ3
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q8IYH5

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006325 - chromatin organization
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1315029

KAT2A
Histone acetyltransferase KAT2A

5

3

Small-scale

0.909

High

1315055

CSR2B
Cysteine-rich protein 2-binding protein

4

3

Small-scale

0.881

High

283503

TAD2A
Transcriptional adapter 2-alpha

4

3

Small-scale

0.867

High

1315030

KAT2B
Histone acetyltransferase KAT2B

2

3

High-throughput

0.754

High

1315037

SGF29
SAGA-associated factor 29

9

1

Small-scale

0.752

High

965082

WDR5
WD repeat-containing protein 5

7

1

High-throughput

0.748

High

284844

TADA3
Transcriptional adapter 3

6

1

High-throughput

0.729

High

1315061

MBIP1
MAP3K12-binding inhibitory protein 1

6

1

High-throughput

0.729

High

1315074

YETS2
YEATS domain-containing protein 2

3

2

Small-scale

0.640

High

610400

PRS6A
26S proteasome regulatory subunit 6A

3

0

High-throughput

0.638

High

960483

PSME3
Proteasome activator complex subunit 3

3

0

High-throughput

0.638

High

1257245

RFPLB
Ret finger protein-like 4B

3

0

High-throughput

0.638

High

1315078

CARD8
Caspase recruitment domain-containing protein 8

3

0

High-throughput

0.638

High

848798

MAGAA
Melanoma-associated antigen 10

3

0

High-throughput

0.634

High

1315053

IKZF5
Zinc finger protein Pegasus

2

1

High-throughput

0.628

High

1287307

TAD2B
Transcriptional adapter 2-beta

1

3

High-throughput

0.618

High

1315072

RCOR1
REST corepressor 1

1

1

High-throughput

0.618

High

1031920

NC2B
Protein Dr1

2

2

High-throughput

0.611

High

1090777

TRAF2
TNF receptor-associated factor 2

2

1

High-throughput

0.606

High

681868

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

1233757

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

246746

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.586

High

1109879

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.586

High

1063419

GOGA2
Golgin subfamily A member 2

2

0

High-throughput

0.580

High

1315041

ASPP1
Apoptosis-stimulating of p53 protein 1

2

0

High-throughput

0.580

High

1315050

CAD19
Cadherin-19

2

1

High-throughput

0.558

High

952951

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.536

High

961614

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

High-throughput

0.536

High

1315059

DPOE4
DNA polymerase epsilon subunit 4

1

1

High-throughput

0.536

High

590453

GATA1
Erythroid transcription factor

1

0

High-throughput

0.518

High

1315020

TRI22
E3 ubiquitin-protein ligase TRIM22

1

0

High-throughput

0.518

High

1315024

ZN513
Zinc finger protein 513

1

0

High-throughput

0.518

High

1315031

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.518

High

1315034

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

0

High-throughput

0.518

High

1315039

ZN496
Zinc finger protein 496

1

0

High-throughput

0.518

High

1315040

MAML3
Mastermind-like protein 3

1

0

High-throughput

0.518

High

1315052

GO45
Golgin-45

1

0

High-throughput

0.518

High

1315070

ZN212
Zinc finger protein 212

1

0

High-throughput

0.518

High

1315085

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.518

High

665271

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.513

High

685643

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.513

High

1004803

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.513

High

1099724

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1123035

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.513

High

1163047

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1315022

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1315028

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

1315036

ZN653
Zinc finger protein 653

1

0

High-throughput

0.513

High

1315077

RUVB2
RuvB-like 2

1

0

High-throughput

0.513

High

1315081

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.513

High

1315023

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

3

High-throughput

0.494

High

1315049

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

1

High-throughput

0.494

High

1209372

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.480

High

71455

P20L1
PHD finger protein 20-like protein 1

1

2

High-throughput

0.479

High

175904

SET1A
Histone-lysine N-methyltransferase SETD1A

1

3

High-throughput

0.479

High

284967

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

2

High-throughput

0.479

High

339796

KLF8
Krueppel-like factor 8

1

2

High-throughput

0.479

High

372536

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406376

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

714259

PML
Protein PML

1

1

High-throughput

0.479

High

739005

ELF1
ETS-related transcription factor Elf-1

1

1

High-throughput

0.479

High

789524

PPARG
Peroxisome proliferator-activated receptor gamma

1

1

High-throughput

0.479

High

799284

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

862289

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

905441

HCFC1
Host cell factor 1

1

3

High-throughput

0.479

High

928300

ATN1
Atrophin-1

1

1

High-throughput

0.479

High

944702

KLF3
Krueppel-like factor 3

1

2

High-throughput

0.479

High

1041556

KMT2A
Histone-lysine N-methyltransferase 2A

1

3

High-throughput

0.479

High

1145490

RBBP5
Retinoblastoma-binding protein 5

1

2

High-throughput

0.479

High

1159307

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.479

High

1220632

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1241466

EDC4
Enhancer of mRNA-decapping protein 4

1

1

High-throughput

0.479

High

1314300

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

1315027

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

1315044

ELF4
ETS-related transcription factor Elf-4

1

1

High-throughput

0.479

High

1315046

PHF20
PHD finger protein 20

1

3

High-throughput

0.479

High

1315048

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

1315057

TAF9B
Transcription initiation factor TFIID subunit 9B

1

1

High-throughput

0.479

High

1315063

CXXC1
CXXC-type zinc finger protein 1

1

2

High-throughput

0.479

High

1315066

RERE
Arginine-glutamic acid dipeptide repeats protein

1

3

High-throughput

0.479

High

1315067

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

3

High-throughput

0.479

High

1315075

KMT2B
Histone-lysine N-methyltransferase 2B

1

3

High-throughput

0.479

High

1315076

SET1B
Histone-lysine N-methyltransferase SETD1B

1

3

High-throughput

0.479

High

1315082

KLF12
Krueppel-like factor 12

1

2

High-throughput

0.479

High

1315083

HCFC2
Host cell factor 2

1

3

High-throughput

0.479

High

995689

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.470

High

194586

KDM6A
Lysine-specific demethylase 6A

1

0

High-throughput

0.458

High

283611

SUPT3
Transcription initiation protein SPT3 homolog

1

0

High-throughput

0.458

High

319160

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.458

High

414182

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

581691

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.458

High

675580

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

833991

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

High-throughput

0.458

High

881563

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.458

High

961773

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

979964

H4
Histone H4

1

0

High-throughput

0.458

High

1029112

E2F1
Transcription factor E2F1

1

0

High-throughput

0.458

High

1032016

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1088906

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1133526

NFIX
Nuclear factor 1 X-type

1

0

High-throughput

0.458

High

1276081

KANL1
KAT8 regulatory NSL complex subunit 1

1

0

High-throughput

0.458

High

1276467

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1313251

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1315026

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.458

High

1315032

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

1315033

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.458

High

1315038

MCRS1
Microspherule protein 1

1

0

High-throughput

0.458

High

1315047

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1315054

KAT8
Histone acetyltransferase KAT8

1

0

High-throughput

0.458

High

1315056

KANL2
KAT8 regulatory NSL complex subunit 2

1

0

High-throughput

0.458

High

1315062

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1315064

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.458

High

1315065

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.458

High

1315069

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

1315071

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1315073

ZN608
Zinc finger protein 608

1

0

High-throughput

0.458

High

1315080

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1315084

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.458

High

1315079

WDR37
WD repeat-containing protein 37

1

2

High-throughput

0.437

High

1315042

Q96KY9
CDH19 protein

1

1

High-throughput

0.407

High

931197

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

2

0

High-throughput

0.328

High

1162751

KAT1
Kynurenine--oxoglutarate transaminase 1

2

0

High-throughput

0.328

High

1315025

CBY2
Protein chibby homolog 2

2

0

High-throughput

0.328

High

1315058

PFD4
Prefoldin subunit 4

2

0

High-throughput

0.328

High

1206403

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

1315051

CARD9
Caspase recruitment domain-containing protein 9

2

0

High-throughput

0.316

High

1315060

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

1289911

F124A
Protein FAM124A

1

0

High-throughput

0.299

High

549636

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

1156306

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.279

Low

1315021

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

0

High-throughput

0.279

Low

1315043

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1315045

DHB14
L-fucose dehydrogenase

1

0

High-throughput

0.279

Low

1315068

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.265

Low

1090352

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

High-throughput

0.251

Low

363546

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.249

Low

378508

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.249

Low

1315035

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025