Protein: KMT2E
Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5)

Gene: KMT2E
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q8IZD2

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0002446 - neutrophil mediated immunity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1316165

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

20

Small-scale

0.647

High

1066387

RBBP4
Histone-binding protein RBBP4

1

20

Small-scale

0.618

High

1125154

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

4

Small-scale

0.618

High

1316157

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

20

Small-scale

0.618

High

1316158

WDR12
Ribosome biogenesis protein WDR12

1

15

Small-scale

0.618

High

1316163

WDR6
tRNA

1

20

Small-scale

0.618

High

1316161

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

0

Small-scale

0.586

High

553010

PIP
Prolactin-inducible protein

2

0

High-throughput

0.576

High

1316162

AT131
Endoplasmic reticulum transmembrane helix translocase

2

5

High-throughput

0.553

High

1200133

BOREA
Borealin

1

0

Small-scale

0.537

High

1112594

CUL1
Cullin-1

1

9

High-throughput

0.536

High

414185

P53
Cellular tumor antigen p53

1

6

Small-scale

0.534

High

351427

NCTR2
Natural cytotoxicity triggering receptor 2

1

2

Small-scale

0.534

High

219198

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.518

High

443435

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.501

High

855679

CRK
Adapter molecule crk

1

8

High-throughput

0.501

High

132495

CDC7
Cell division cycle 7-related protein kinase

1

9

Small-scale

0.479

High

138722

IMA4
Importin subunit alpha-4

1

7

Small-scale

0.479

High

185843

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

11

Small-scale

0.479

High

212278

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

2

Small-scale

0.479

High

345092

RIGI
Antiviral innate immune response receptor RIG-I

1

13

Small-scale

0.479

High

472883

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.479

High

519401

MYB
Transcriptional activator Myb

1

5

High-throughput

0.479

High

542575

TOP2A
DNA topoisomerase 2-alpha

1

4

Small-scale

0.479

High

613098

EGR1
Early growth response protein 1

1

6

High-throughput

0.479

High

636113

CD11B
Cyclin-dependent kinase 11B

1

6

Small-scale

0.479

High

667929

CDK2
Cyclin-dependent kinase 2

1

4

Small-scale

0.479

High

669939

MCM3
DNA replication licensing factor MCM3

1

14

Small-scale

0.479

High

675581

TYY1
Transcriptional repressor protein YY1

1

8

Small-scale

0.479

High

905442

HCFC1
Host cell factor 1

1

12

Small-scale

0.479

High

1089474

ILF2
Interleukin enhancer-binding factor 2

1

5

Small-scale

0.479

High

1109881

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

1126998

RBM39
RNA-binding protein 39

1

11

Small-scale

0.479

High

1131070

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

Small-scale

0.479

High

1271451

DHX30
ATP-dependent RNA helicase DHX30

1

8

Small-scale

0.479

High

1279863

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

14

Small-scale

0.479

High

1316154

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

Small-scale

0.479

High

1316155

SIN3A
Paired amphipathic helix protein Sin3a

1

7

Small-scale

0.479

High

1316156

DDX50
ATP-dependent RNA helicase DDX50

1

9

Small-scale

0.479

High

1316159

DDX24
ATP-dependent RNA helicase DDX24

1

8

Small-scale

0.479

High

1316160

ZN768
Zinc finger protein 768

1

3

Small-scale

0.479

High

1316166

VPS4A
Vacuolar protein sorting-associated protein 4A

1

3

Small-scale

0.479

High

1316167

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.479

High

1316168

TRAF6
TNF receptor-associated factor 6

1

13

Small-scale

0.479

High

1004807

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1316164

DDX18
ATP-dependent RNA helicase DDX18

1

8

Small-scale

0.437

High


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Last updated: 11Aug2025