Protein: PIP
Prolactin-inducible protein (Gross cystic disease fluid protein 15) (GCDFP-15) (Prolactin-induced protein) (Secretory actin-binding protein) (SABP) (gp17)

Gene: PIP
Organism: Homo sapiens
Interactions: 239
UniProt ID: P12273

Gene Ontology (top 5):
GO:0001580 - detection of chemical stimulus involved in sensory perception of bitter taste
GO:0002682 - regulation of immune system process
GO:0003779 - actin binding
GO:0004190 - aspartic-type endopeptidase activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

371039

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

553074

DDX31
ATP-dependent DNA helicase DDX31

2

1

High-throughput

0.628

High

552964

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

1

High-throughput

0.611

High

273644

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

1

High-throughput

0.601

High

552942

NFKB2
Nuclear factor NF-kappa-B p100 subunit

2

4

High-throughput

0.601

High

552946

TF65
Transcription factor p65

2

4

High-throughput

0.601

High

552949

FAK1
Focal adhesion kinase 1

2

1

High-throughput

0.601

High

552954

STRN3
Striatin-3

2

1

High-throughput

0.601

High

552956

TOP3A
DNA topoisomerase 3-alpha

2

1

High-throughput

0.601

High

160678

TOR1A
Torsin-1A

2

0

High-throughput

0.594

High

552928

RBP2
E3 SUMO-protein ligase RanBP2

2

0

High-throughput

0.576

High

552932

SMTN
Smoothelin

2

0

High-throughput

0.576

High

552957

PICAL
Phosphatidylinositol-binding clathrin assembly protein

2

0

High-throughput

0.576

High

552967

CND1
Condensin complex subunit 1

2

0

High-throughput

0.576

High

552971

INF2
Inverted formin-2

2

0

High-throughput

0.576

High

552972

QRIC1
Transcriptional regulator QRICH1

2

0

High-throughput

0.576

High

552973

GRDN
Girdin

2

0

High-throughput

0.576

High

552982

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

2

0

High-throughput

0.576

High

552983

STRP1
Striatin-interacting protein 1

2

0

High-throughput

0.576

High

552998

NPHP3
Nephrocystin-3

2

0

High-throughput

0.576

High

552999

KAISO
Transcriptional regulator Kaiso

2

0

High-throughput

0.576

High

553005

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

0

High-throughput

0.576

High

553010

KMT2E
Inactive histone-lysine N-methyltransferase 2E

2

0

High-throughput

0.576

High

553029

N42L2
NEDD4-binding protein 2-like 2

2

0

High-throughput

0.576

High

553040

IP3KC
Inositol-trisphosphate 3-kinase C

2

0

High-throughput

0.576

High

552914

NFKB1
Nuclear factor NF-kappa-B p105 subunit

2

4

High-throughput

0.552

High

67755

TBKB1
TANK-binding kinase 1-binding protein 1

2

1

High-throughput

0.549

High

553082

STRN4
Striatin-4

2

1

High-throughput

0.549

High

553092

TBK1
Serine/threonine-protein kinase TBK1

2

1

High-throughput

0.549

High

254034

CTND1
Catenin delta-1

1

1

High-throughput

0.536

High

341512

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.536

High

552948

UBE3A
Ubiquitin-protein ligase E3A

1

1

High-throughput

0.536

High

552950

RING1
E3 ubiquitin-protein ligase RING1

1

3

High-throughput

0.536

High

552952

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

4

High-throughput

0.536

High

552962

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

3

High-throughput

0.536

High

552989

ANR54
Ankyrin repeat domain-containing protein 54

1

1

High-throughput

0.536

High

552992

BCOR
BCL-6 corepressor

1

2

High-throughput

0.536

High

553033

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

1

High-throughput

0.536

High

553039

ZBT10
Zinc finger and BTB domain-containing protein 10

1

1

High-throughput

0.536

High

553042

GWL
Serine/threonine-protein kinase greatwall

1

2

High-throughput

0.536

High

553043

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

High-throughput

0.536

High

553050

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.536

High

553051

EYA1
Protein phosphatase EYA1

1

1

High-throughput

0.536

High

553055

PCGF1
Polycomb group RING finger protein 1

1

3

High-throughput

0.536

High

553063

RHG39
Rho GTPase-activating protein 39

1

1

High-throughput

0.536

High

553072

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.536

High

553075

RMI1
RecQ-mediated genome instability protein 1

1

1

High-throughput

0.536

High

553093

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

1

High-throughput

0.536

High

553021

ARH40
Rho guanine nucleotide exchange factor 40

2

1

High-throughput

0.521

High

47952

RBM47
RNA-binding protein 47

1

0

High-throughput

0.513

High

217047

MS18B
Protein Mis18-beta

1

0

High-throughput

0.513

High

298569

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.513

High

341892

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

413091

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

552910

HXB9
Homeobox protein Hox-B9

1

0

High-throughput

0.513

High

552913

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

552926

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

High-throughput

0.513

High

552969

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.513

High

552977

CRTC2
CREB-regulated transcription coactivator 2

1

0

High-throughput

0.513

High

552981

UBAP2
Ubiquitin-associated protein 2

1

0

High-throughput

0.513

High

552985

RN220
E3 ubiquitin-protein ligase RNF220

1

0

High-throughput

0.513

High

552987

USPL1
SUMO-specific isopeptidase USPL1

1

0

High-throughput

0.513

High

552990

CDC73
Parafibromin

1

0

High-throughput

0.513

High

553004

ZGRF1
5'-3' DNA helicase ZGRF1

1

0

High-throughput

0.513

High

553015

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.513

High

553019

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.513

High

553020

CCHCR
Coiled-coil alpha-helical rod protein 1

1

0

High-throughput

0.513

High

553024

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

553031

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.513

High

553038

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.513

High

553044

LMLN
Leishmanolysin-like peptidase

1

0

High-throughput

0.513

High

553052

CTIP
DNA endonuclease RBBP8

1

0

High-throughput

0.513

High

553054

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

553057

CDK19
Cyclin-dependent kinase 19

1

0

High-throughput

0.513

High

553069

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.513

High

553073

AUNIP
Aurora kinase A- and ninein-interacting protein

1

0

High-throughput

0.513

High

553095

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.513

High

553098

POLH
DNA polymerase eta

1

0

High-throughput

0.513

High

553103

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.513

High

552929

DYN2
Dynamin-2

1

0

High-throughput

0.493

High

553013

NIN
Ninein

1

1

High-throughput

0.489

High

553071

AZI2
5-azacytidine-induced protein 2

1

1

High-throughput

0.489

High

553030

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.480

High

180681

TIF1A
Transcription intermediary factor 1-alpha

1

2

Small-scale

0.479

High

405736

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

552919

PML
Protein PML

1

2

High-throughput

0.479

High

552920

MCM5
DNA replication licensing factor MCM5

1

1

High-throughput

0.479

High

552927

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

552930

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

552937

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

552951

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

552959

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.479

High

553028

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

553090

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

553100

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

1

Small-scale

0.479

High

122909

SGK1
Serine/threonine-protein kinase Sgk1

1

0

High-throughput

0.458

High

131701

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

Small-scale

0.458

High

141300

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

240611

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

347499

BAG3
BAG family molecular chaperone regulator 3

1

0

Small-scale

0.458

High

400207

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

444890

S10A9
Protein S100-A9

1

0

High-throughput

0.458

High

552906

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

552907

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

552908

HIS3
Histatin-3

1

0

Small-scale

0.458

High

552909

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

552912

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

552917

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

552923

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

552935

LYSC
Lysozyme C

1

0

High-throughput

0.458

High

552941

VIGLN
Vigilin

1

0

High-throughput

0.458

High

552974

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

552993

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.458

High

553006

PHF6
PHD finger protein 6

1

0

Small-scale

0.458

High

553016

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

553034

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

553058

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

553060

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

553062

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

553066

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

553080

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

553081

ANLN
Anillin

1

0

High-throughput

0.458

High

553094

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.458

High

553105

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

552938

NUCB2
Nucleobindin-2

1

1

High-throughput

0.445

High

552943

RELB
Transcription factor RelB

1

4

High-throughput

0.445

High

552944

TAGL
Transgelin

1

1

High-throughput

0.445

High

552945

NUCB1
Nucleobindin-1

1

1

High-throughput

0.445

High

552976

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.445

High

553023

LMO7
LIM domain only protein 7

1

1

High-throughput

0.445

High

553053

PKP2
Plakophilin-2

1

1

High-throughput

0.445

High

553097

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.445

High

323135

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.437

High

552968

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.437

High

553064

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.437

High

553099

NINL
Ninein-like protein

1

1

High-throughput

0.437

High

174304

ZN609
Zinc finger protein 609

1

0

High-throughput

0.426

High

245666

GANP
Germinal-center associated nuclear protein

1

0

High-throughput

0.426

High

429211

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

552915

FBLN1
Fibulin-1

1

0

High-throughput

0.426

High

552916

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.426

High

552918

CCN2
CCN family member 2

1

0

High-throughput

0.426

High

552922

FUS
RNA-binding protein FUS

1

0

High-throughput

0.426

High

552925

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.426

High

552939

ATL3
ADAMTS-like protein 3

1

0

High-throughput

0.426

High

552955

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

0

High-throughput

0.426

High

552958

SHRM2
Protein Shroom2

1

0

High-throughput

0.426

High

552963

RFTN1
Raftlin

1

0

High-throughput

0.426

High

552978

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

552991

GASP3
G protein-coupled receptor associated sorting protein 3

1

0

High-throughput

0.426

High

553001

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.426

High

553007

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.426

High

553027

ESR2
Estrogen receptor beta

1

0

High-throughput

0.426

High

553046

TREF1
Transcriptional-regulating factor 1

1

0

High-throughput

0.426

High

553048

CK5P2
CDK5 regulatory subunit-associated protein 2

1

0

High-throughput

0.426

High

553056

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.426

High

553079

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.426

High

553083

BMP2K
BMP-2-inducible protein kinase

1

0

High-throughput

0.426

High

553084

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.426

High

553085

PARVA
Alpha-parvin

1

0

High-throughput

0.426

High

553087

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.426

High

553101

PRG3
Proteoglycan 3

1

0

High-throughput

0.426

High

552970

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

1

High-throughput

0.407

High

552988

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.407

High

552994

DNMBP
Dynamin-binding protein

1

1

High-throughput

0.407

High

553036

RCN3
Reticulocalbin-3

1

1

High-throughput

0.407

High

553041

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.407

High

208615

SI1L1
Signal-induced proliferation-associated 1-like protein 1

2

0

High-throughput

0.313

High

320529

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

2

0

High-throughput

0.313

High

552931

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

2

0

High-throughput

0.313

High

552933

HUNK
Hormonally up-regulated neu tumor-associated kinase

2

0

High-throughput

0.313

High

552953

TIAM1
Rho guanine nucleotide exchange factor TIAM1

2

0

High-throughput

0.313

High

552966

CND2
Condensin complex subunit 2

2

0

High-throughput

0.313

High

552984

CE350
Centrosome-associated protein 350

2

0

High-throughput

0.313

High

552995

GGYF2
GRB10-interacting GYF protein 2

2

0

High-throughput

0.313

High

553009

M21D2
Nucleotidyltransferase MB21D2

2

0

High-throughput

0.313

High

553018

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.313

High

553026

K0232
Uncharacterized protein KIAA0232

2

0

High-throughput

0.313

High

553037

REPS1
RalBP1-associated Eps domain-containing protein 1

2

0

High-throughput

0.313

High

553070

WDCP
WD repeat and coiled-coil-containing protein

2

0

High-throughput

0.313

High

553076

SPE39
Spermatogenesis-defective protein 39 homolog

2

0

High-throughput

0.313

High

553088

CT2NL
CTTNBP2 N-terminal-like protein

2

0

High-throughput

0.313

High

553091

SUN2
SUN domain-containing protein 2

2

0

High-throughput

0.313

High

136590

MANBA
Beta-mannosidase

1

0

High-throughput

0.279

Low

252003

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.279

Low

317707

NOL4
Nucleolar protein 4

1

0

High-throughput

0.279

Low

317759

KBTBB
Kelch repeat and BTB domain-containing protein 11

1

0

High-throughput

0.279

Low

552924

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.279

Low

552936

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

552965

SLMAP
Sarcolemmal membrane-associated protein

1

0

High-throughput

0.279

Low

552975

IQCC
IQ domain-containing protein C

1

0

High-throughput

0.279

Low

552996

AEBP2
Zinc finger protein AEBP2

1

0

High-throughput

0.279

Low

552997

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

High-throughput

0.279

Low

553003

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.279

Low

553011

RBFA
Putative ribosome-binding factor A, mitochondrial

1

0

High-throughput

0.279

Low

553012

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.279

Low

553022

DI3L1
DIS3-like exonuclease 1

1

0

High-throughput

0.279

Low

553032

P2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

1

0

High-throughput

0.279

Low

553035

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.279

Low

553047

ALPK1
Alpha-protein kinase 1

1

0

High-throughput

0.279

Low

553049

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.279

Low

553059

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

0

High-throughput

0.279

Low

553061

YTHD1
YTH domain-containing family protein 1

1

0

High-throughput

0.279

Low

553065

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.279

Low

553068

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.279

Low

553077

TAF9B
Transcription initiation factor TFIID subunit 9B

1

0

High-throughput

0.279

Low

553078

ZDBF2
DBF4-type zinc finger-containing protein 2

1

0

High-throughput

0.279

Low

553089

FA8A1
Protein FAM8A1

1

0

High-throughput

0.279

Low

553102

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.279

Low

378823

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.261

Low

293130

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

552921

GRK5
G protein-coupled receptor kinase 5

1

0

High-throughput

0.249

Low

552934

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

552947

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.249

Low

552961

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

552986

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

553000

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.249

Low

553002

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

553008

SLX4
Structure-specific endonuclease subunit SLX4

1

0

Small-scale

0.249

Low

553017

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

553086

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

553106

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

0

High-throughput

0.249

Low

907

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

75618

IQIP1
IQCJ-SCHIP1 readthrough transcript protein

1

0

High-throughput

0.232

Low

87321

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

177165

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.232

Low

213055

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

239696

PCDH7
Protocadherin-7

1

0

High-throughput

0.232

Low

552911

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.232

Low

552940

DAB2
Disabled homolog 2

1

0

High-throughput

0.232

Low

552960

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low

552979

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.232

Low

552980

MPP7
MAGUK p55 subfamily member 7

1

0

High-throughput

0.232

Low

553014

POC5
Centrosomal protein POC5

1

0

High-throughput

0.232

Low

553025

TM131
Transmembrane protein 131

1

0

High-throughput

0.232

Low

553045

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.232

Low

553067

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

0

High-throughput

0.232

Low

553096

S12A4
Solute carrier family 12 member 4

1

0

High-throughput

0.232

Low

553104

STA13
StAR-related lipid transfer protein 13

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025