Protein: SRF
Serum response factor (SRF)

Gene: SRF
Organism: Homo sapiens
Interactions: 109
UniProt ID: P11831

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001569 - branching involved in blood vessel morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549270

SRF
Serum response factor

3

19

Small-scale

0.845

High

549346

MRTFA
Myocardin-related transcription factor A

5

9

Small-scale

0.709

High

549332

HMBX1
Homeobox-containing protein 1

1

4

High-throughput

0.691

High

549338

MYCD
Myocardin

4

4

Small-scale

0.686

High

549281

ELK1
ETS domain-containing protein Elk-1

3

6

Small-scale

0.651

High

549297

GATA4
Transcription factor GATA-4

2

3

Small-scale

0.646

High

549287

ELK4
ETS domain-containing protein Elk-4

3

6

Small-scale

0.637

High

549274

MYOG
Myogenin

2

7

Small-scale

0.625

High

549277

CEBPB
CCAAT/enhancer-binding protein beta

2

3

Small-scale

0.625

High

549343

CBP
CREB-binding protein

2

5

Small-scale

0.620

High

549307

PRKDC
DNA-dependent protein kinase catalytic subunit

2

1

Small-scale

0.619

High

549293

CUX1
Homeobox protein cut-like 1

1

4

High-throughput

0.618

High

549339

SIX5
Homeobox protein SIX5

1

3

High-throughput

0.618

High

549347

NKX31
Homeobox protein Nkx-3.1

1

5

Small-scale

0.618

High

549350

ZHX3
Zinc fingers and homeoboxes protein 3

1

1

High-throughput

0.618

High

549356

SIX4
Homeobox protein SIX4

1

3

High-throughput

0.618

High

549362

ZHX2
Zinc fingers and homeoboxes protein 2

1

1

High-throughput

0.618

High

549358

MRTFB
Myocardin-related transcription factor B

2

5

Small-scale

0.612

High

549300

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

14

Small-scale

0.584

High

549288

TEAD1
Transcriptional enhancer factor TEF-1

1

2

Small-scale

0.578

High

549291

T2FA
General transcription factor IIF subunit 1

2

0

Small-scale

0.569

High

549289

PML
Protein PML

1

1

Small-scale

0.561

High

549303

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.561

High

549308

FOXK1
Forkhead box protein K1

1

2

Small-scale

0.561

High

549322

FHL2
Four and a half LIM domains protein 2

1

1

Small-scale

0.561

High

549306

GTF2I
General transcription factor II-I

2

0

Small-scale

0.560

High

549273

MYOD1
Myoblast determination protein 1

1

6

Small-scale

0.552

High

343887

HS74L
Heat shock 70 kDa protein 4L

1

5

High-throughput

0.536

High

486898

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

549282

CSK22
Casein kinase II subunit alpha'

1

11

High-throughput

0.536

High

549309

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.536

High

549315

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.536

High

549320

NFYC
Nuclear transcription factor Y subunit gamma

1

1

High-throughput

0.536

High

549335

VRK3
Serine/threonine-protein kinase VRK3

1

1

High-throughput

0.536

High

549354

UBIP1
Upstream-binding protein 1

1

2

High-throughput

0.536

High

549355

TRPS1
Zinc finger transcription factor Trps1

1

4

High-throughput

0.536

High

549360

TTF2
Transcription termination factor 2

1

11

High-throughput

0.536

High

194503

KDM6A
Lysine-specific demethylase 6A

1

0

Small-scale

0.529

High

520499

RARA
Retinoic acid receptor alpha

1

3

Small-scale

0.527

High

549279

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

1

Small-scale

0.527

High

549285

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.527

High

549298

RXRG
Retinoic acid receptor RXR-gamma

1

2

Small-scale

0.527

High

549326

NCOA1
Nuclear receptor coactivator 1

1

5

Small-scale

0.527

High

549361

NCOR2
Nuclear receptor corepressor 2

1

2

Small-scale

0.527

High

549290

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.518

High

549321

CIRBP
Cold-inducible RNA-binding protein

1

0

High-throughput

0.518

High

283651

GPC4
Glypican-4

1

0

High-throughput

0.513

High

285574

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.513

High

518958

RO60
RNA-binding protein RO60

1

0

High-throughput

0.513

High

549276

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.513

High

549280

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

549286

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.513

High

549299

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

549301

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.513

High

549333

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.513

High

549342

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.513

High

549359

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.513

High

549325

TRIP4
Activating signal cointegrator 1

1

0

Small-scale

0.504

High

249334

ZIC3
Zinc finger protein ZIC 3

1

1

Small-scale

0.501

High

464778

SP1
Transcription factor Sp1

1

7

Small-scale

0.501

High

549284

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

Small-scale

0.501

High

549302

FOXG1
Forkhead box protein G1

1

2

Small-scale

0.501

High

549304

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.501

High

549305

CSK21
Casein kinase II subunit alpha

1

7

Small-scale

0.501

High

549310

FLI1
Friend leukemia integration 1 transcription factor

1

6

Small-scale

0.501

High

549312

TF65
Transcription factor p65

1

4

Small-scale

0.501

High

549313

REL
Proto-oncogene c-Rel

1

4

Small-scale

0.501

High

549318

FHL1
Four and a half LIM domains protein 1

1

1

Small-scale

0.501

High

549323

NCOA6
Nuclear receptor coactivator 6

1

2

Small-scale

0.501

High

549272

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

Small-scale

0.493

High

549283

RXRA
Retinoic acid receptor RXR-alpha

1

2

Small-scale

0.481

High

549341

SRFB1
Serum response factor-binding protein 1

1

0

Small-scale

0.480

High

549344

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.480

High

177646

SMAD7
Mothers against decapentaplegic homolog 7

1

3

Small-scale

0.479

High

188158

HDAC3
Histone deacetylase 3

1

5

Small-scale

0.479

High

244068

ZN292
Zinc finger protein 292

1

1

High-throughput

0.479

High

549275

ZEP1
Zinc finger protein 40

1

2

High-throughput

0.479

High

549278

EGR1
Early growth response protein 1

1

3

Small-scale

0.479

High

549292

ZEB1
Zinc finger E-box-binding homeobox 1

1

2

High-throughput

0.479

High

549296

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

549311

SP2
Transcription factor Sp2

1

8

High-throughput

0.479

High

549314

SSRP1
FACT complex subunit SSRP1

1

1

Small-scale

0.479

High

549316

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

5

Small-scale

0.479

High

549324

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

549329

ARID2
AT-rich interactive domain-containing protein 2

1

2

High-throughput

0.479

High

549330

Z518A
Zinc finger protein 518A

1

1

High-throughput

0.479

High

549331

ADNP2
Activity-dependent neuroprotector homeobox protein 2

1

1

High-throughput

0.479

High

549334

POGZ
Pogo transposable element with ZNF domain

1

1

High-throughput

0.479

High

549336

FOXP4
Forkhead box protein P4

1

3

High-throughput

0.479

High

549337

ARI3B
AT-rich interactive domain-containing protein 3B

1

2

High-throughput

0.479

High

549340

PHC3
Polyhomeotic-like protein 3

1

2

High-throughput

0.479

High

549348

EPC1
Enhancer of polycomb homolog 1

1

1

Small-scale

0.479

High

549352

TF7L2
Transcription factor 7-like 2

1

5

High-throughput

0.479

High

477392

CD63
CD63 antigen

1

0

Small-scale

0.460

High

549345

TRI63
E3 ubiquitin-protein ligase TRIM63

1

0

Small-scale

0.460

High

349761

SNAI1
Zinc finger protein SNAI1

1

0

Small-scale

0.458

High

549271

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

549317

CUL3
Cullin-3

1

0

High-throughput

0.458

High

549328

BCORL
BCL-6 corepressor-like protein 1

1

0

High-throughput

0.458

High

549351

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.458

High

549357

GMEB2
Glucocorticoid modulatory element-binding protein 2

1

0

High-throughput

0.458

High

549295

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

1

High-throughput

0.445

High

549319

CASP
Protein CASP

1

2

High-throughput

0.445

High

549327

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

549294

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

549349

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low

549353

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.279

Low

407781

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025