Protein: ESPB1
Epididymal sperm-binding protein 1 (Epididymal secretory protein 12) (hE12)

Gene: ESPB1, ELSPBP1
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q96BH3

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0007338 - single fertilization
GO:0008201 - heparin binding
GO:0009986 - cell surface
GO:0048240 - sperm capacitation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1384582

ESPB1
Epididymal sperm-binding protein 1

1

8

Small-scale

0.647

High

1243282

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

1

High-throughput

0.618

High

1312529

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

1

High-throughput

0.618

High

937427

LAMB2
Laminin subunit beta-2

2

3

High-throughput

0.601

High

1117013

LAMB3
Laminin subunit beta-3

2

5

High-throughput

0.601

High

1177240

MICA
MHC class I polypeptide-related sequence A

2

2

High-throughput

0.601

High

1248338

PLGT2
Protein O-glucosyltransferase 2

2

1

High-throughput

0.549

High

1384603

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

2

2

High-throughput

0.549

High

581712

MYOD1
Myoblast determination protein 1

2

2

Small-scale

0.543

High

133194

QSOX1
Sulfhydryl oxidase 1

1

3

High-throughput

0.536

High

136956

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

6

High-throughput

0.536

High

144062

MA2B1
Lysosomal alpha-mannosidase

1

2

High-throughput

0.536

High

183289

LAMA5
Laminin subunit alpha-5

1

6

High-throughput

0.536

High

211939

SPIT1
Kunitz-type protease inhibitor 1

1

8

High-throughput

0.536

High

336201

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

2

High-throughput

0.536

High

350728

NOE2
Noelin-2

1

2

High-throughput

0.536

High

452109

PROS
Vitamin K-dependent protein S

1

13

High-throughput

0.536

High

467846

BGLR
Beta-glucuronidase

1

1

High-throughput

0.536

High

472199

TRFM
Melanotransferrin

1

1

High-throughput

0.536

High

562748

BMP1
Bone morphogenetic protein 1

1

8

High-throughput

0.536

High

571245

PERF
Perforin-1

1

2

High-throughput

0.536

High

590929

TIMP2
Metalloproteinase inhibitor 2

1

9

High-throughput

0.536

High

648622

FGFR4
Fibroblast growth factor receptor 4

1

7

High-throughput

0.536

High

650340

FGFR3
Fibroblast growth factor receptor 3

1

7

High-throughput

0.536

High

654546

FBLN1
Fibulin-1

1

13

High-throughput

0.536

High

709077

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

8

High-throughput

0.536

High

719734

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

1

High-throughput

0.536

High

756579

GALNS
N-acetylgalactosamine-6-sulfatase

1

7

High-throughput

0.536

High

857529

NOTC1
Neurogenic locus notch homolog protein 1

1

7

High-throughput

0.536

High

1047682

NOTC2
Neurogenic locus notch homolog protein 2

1

6

High-throughput

0.536

High

1055342

APLP2
Amyloid beta precursor like protein 2

1

8

High-throughput

0.536

High

1105761

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

3

High-throughput

0.536

High

1248920

ARSK
Arylsulfatase K

1

7

High-throughput

0.536

High

1324217

VWDE
von Willebrand factor D and EGF domain-containing protein

1

5

High-throughput

0.536

High

1333889

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

2

High-throughput

0.536

High

1384590

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

2

High-throughput

0.536

High

1384610

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

3

High-throughput

0.536

High

1384583

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

1384584

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.513

High

1384616

AGRG1
Adhesion G-protein coupled receptor G1

1

0

High-throughput

0.513

High

296372

ATRN
Attractin

1

8

High-throughput

0.489

High

343631

OXSR1
Serine/threonine-protein kinase OSR1

1

2

High-throughput

0.489

High

501779

RB40L
Ras-related protein Rab-40A-like

1

7

High-throughput

0.489

High

1030425

DIAC
Di-N-acetylchitobiase

1

1

High-throughput

0.489

High

1034314

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

10

High-throughput

0.489

High

1154253

NPTX1
Neuronal pentraxin-1

1

3

High-throughput

0.489

High

1191926

TBB8
Tubulin beta-8 chain

1

5

High-throughput

0.489

High

1212682

GT253
Inactive glycosyltransferase 25 family member 3

1

2

High-throughput

0.489

High

1225407

METRL
Meteorin-like protein

1

1

High-throughput

0.489

High

1247504

POTEE
POTE ankyrin domain family member E

1

4

High-throughput

0.489

High

1249901

CREL2
Protein disulfide isomerase CRELD2

1

5

High-throughput

0.489

High

1251905

THSD4
Thrombospondin type-1 domain-containing protein 4

1

1

High-throughput

0.489

High

1281697

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

13

High-throughput

0.489

High

1295792

C1QL4
Complement C1q-like protein 4

1

10

High-throughput

0.489

High

1333650

PGLT1
Protein O-glucosyltransferase 1

1

1

High-throughput

0.489

High

1334399

UXS1
UDP-glucuronic acid decarboxylase 1

1

2

High-throughput

0.489

High

1336105

KREM2
Kremen protein 2

1

13

High-throughput

0.489

High

1383759

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

1

2

High-throughput

0.489

High

1384592

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

4

High-throughput

0.489

High

1384594

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

4

High-throughput

0.489

High

1384595

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

2

High-throughput

0.489

High

1384596

CHRD
Chordin

1

11

High-throughput

0.489

High

1384598

ZN703
Zinc finger protein 703

1

4

High-throughput

0.489

High

1384602

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.489

High

1384608

METRN
Meteorin

1

1

High-throughput

0.489

High

1384609

GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

1

2

High-throughput

0.489

High

1384613

LOXL2
Lysyl oxidase homolog 2

1

7

High-throughput

0.489

High

1384615

ST14
Suppressor of tumorigenicity 14 protein

1

7

High-throughput

0.489

High

605214

TAL1
T-cell acute lymphocytic leukemia protein 1

1

1

Small-scale

0.457

High

161072

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

3

High-throughput

0.445

High

376890

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

2

High-throughput

0.445

High

504752

FBSP1
F-box/SPRY domain-containing protein 1

1

6

High-throughput

0.445

High

551811

CO6A1

1

15

High-throughput

0.445

High

626973

FST
Follistatin

1

2

High-throughput

0.445

High

772333

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

13

High-throughput

0.445

High

963969

NPC2
NPC intracellular cholesterol transporter 2

1

1

High-throughput

0.445

High

1384589

ERP44
Endoplasmic reticulum resident protein 44

1

4

High-throughput

0.445

High

1067585

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.437

High

1108875

OLIG2
Oligodendrocyte transcription factor 2

1

2

Small-scale

0.437

High

1151972

TWST1
Twist-related protein 1

1

2

Small-scale

0.437

High

1347275

OLIG1
Oligodendrocyte transcription factor 1

1

2

Small-scale

0.437

High

547188

PYC
Pyruvate carboxylase, mitochondrial

1

2

High-throughput

0.407

High

1220719

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.407

High

1230796

ANR40
Ankyrin repeat domain-containing protein 40

1

1

High-throughput

0.407

High

1287401

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

5

High-throughput

0.407

High

1384585

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

3

High-throughput

0.407

High

1384586

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

2

High-throughput

0.407

High

1384604

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

1

High-throughput

0.407

High

1384605

ZMYM2
Zinc finger MYM-type protein 2

1

1

High-throughput

0.407

High

1384611

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

3

High-throughput

0.407

High

261852

PFD1
Prefoldin subunit 1

2

0

High-throughput

0.313

High

1384588

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.313

High

135821

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

244490

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.279

Low

354160

CLPT1
Putative lipid scramblase CLPTM1

1

0

High-throughput

0.279

Low

771674

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.279

Low

1085952

HYAL1
Hyaluronidase-1

1

0

High-throughput

0.279

Low

1143657

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.279

Low

1193208

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

0

High-throughput

0.279

Low

1204888

MKS3
Meckelin

1

0

High-throughput

0.279

Low

1288097

OAF
Out at first protein homolog

1

0

High-throughput

0.279

Low

1382869

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.279

Low

1384587

JMJD8
JmjC domain-containing protein 8

1

0

High-throughput

0.279

Low

1384597

TOR3A
Torsin-3A

1

0

High-throughput

0.279

Low

1384606

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

1384614

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.279

Low

128462

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.261

Low

182171

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low

963348

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

1359632

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.232

Low

1384591

HGH1
Protein HGH1 homolog

1

0

High-throughput

0.232

Low

1384593

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.232

Low

1384599

SEM4B
Semaphorin-4B

1

0

High-throughput

0.232

Low

1384600

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low

1384601

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

1384607

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

1384612

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025