Protein: HPLN3
Hyaluronan and proteoglycan link protein 3

Gene: HPLN3, HAPLN3
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q96S86

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0005540 - hyaluronic acid binding
GO:0005615 - extracellular space
GO:0007155 - cell adhesion
GO:0007417 - central nervous system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369732

A2MG
Alpha-2-macroglobulin

3

1

High-throughput

0.855

High

1219215

SUSD4
Sushi domain-containing protein 4

2

8

High-throughput

0.705

High

518896

CCL3
C-C motif chemokine 3

1

11

High-throughput

0.691

High

607410

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.691

High

731889

CEAM8
Cell adhesion molecule CEACAM8

1

1

High-throughput

0.691

High

1402435

ST14
Suppressor of tumorigenicity 14 protein

1

4

High-throughput

0.691

High

437768

HEPS
Serine protease hepsin

1

6

High-throughput

0.618

High

567963

PRG2
Bone marrow proteoglycan

1

8

High-throughput

0.618

High

1177870

CL12B
C-type lectin domain family 12 member B

1

6

High-throughput

0.618

High

1402421

TMPSD
Transmembrane protease serine 13

1

5

High-throughput

0.618

High

1402430

BTNL2
Butyrophilin-like protein 2

1

7

High-throughput

0.618

High

1272729

MAEA
E3 ubiquitin-protein transferase MAEA

2

5

High-throughput

0.601

High

1083503

BST1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

1

0

High-throughput

0.578

High

1107463

BIRC2
Baculoviral IAP repeat-containing protein 2

1

0

High-throughput

0.578

High

1295025

TMM25
Transmembrane protein 25

1

0

High-throughput

0.578

High

219353

B4GA1
Beta-1,4-glucuronyltransferase 1

2

1

High-throughput

0.574

High

535436

BIP
Endoplasmic reticulum chaperone BiP

2

6

High-throughput

0.574

High

1357261

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

2

1

High-throughput

0.574

High

1307904

ARMC8
Armadillo repeat-containing protein 8

2

1

High-throughput

0.549

High

141786

MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

1

1

High-throughput

0.536

High

1202224

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.514

High

1336106

KREM2
Kremen protein 2

1

5

High-throughput

0.514

High

1402423

WDR26
WD repeat-containing protein 26

1

3

High-throughput

0.514

High

1402433

PRG3
Proteoglycan 3

1

8

High-throughput

0.514

High

548099

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

1249681

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.513

High

1137962

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.489

High

1402432

B3GT5
Beta-1,3-galactosyltransferase 5

1

1

High-throughput

0.489

High

1360144

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.481

High

702409

CYTD
Cystatin-D

1

0

High-throughput

0.426

High

61598

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.407

High

1250510

RBP10
Ran-binding protein 10

1

3

High-throughput

0.407

High

1335604

SPRY3
SPRY domain-containing protein 3

1

2

High-throughput

0.407

High

1337922

ZNT7
Zinc transporter 7

1

4

High-throughput

0.407

High

1391433

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

4

High-throughput

0.407

High

1402273

RANB9
Ran-binding protein 9

1

3

High-throughput

0.407

High

1402424

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

4

High-throughput

0.407

High

1402428

GID8
Glucose-induced degradation protein 8 homolog

1

5

High-throughput

0.407

High

1160437

TAZ
Tafazzin

3

0

High-throughput

0.347

High

636501

FUT3
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

2

0

High-throughput

0.328

High

1165379

ODAPH
Odontogenesis associated phosphoprotein

2

0

High-throughput

0.328

High

1332462

SAXO5
Stabilizer of axonemal microtubules 5

2

0

High-throughput

0.328

High

1402429

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

0

High-throughput

0.328

High

1402434

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

0

High-throughput

0.328

High

1121168

SRTD2
SERTA domain-containing protein 2

2

0

High-throughput

0.313

High

1150563

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.279

Low

1396503

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

1402422

CHST5
Carbohydrate sulfotransferase 5

1

0

High-throughput

0.279

Low

1402425

PROK2
Prokineticin-2

1

0

High-throughput

0.279

Low

1402427

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

288003

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

High-throughput

0.232

Low

977152

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.232

Low

1309303

GID4
Glucose-induced degradation protein 4 homolog

1

0

High-throughput

0.232

Low

1311160

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.232

Low

1402426

XPP3
Xaa-Pro aminopeptidase 3

1

0

High-throughput

0.232

Low

1402431

MKLN1
Muskelin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025