Protein: SIC1
Protein SIC1 (CDK inhibitor p40)

Gene: SIC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 43
UniProt ID: P38634

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0016242 - negative regulation of macroautophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

364502

CDK1
Cyclin-dependent kinase 1

23

1

Small-scale

0.768

High

718938

CGS5
S-phase entry cyclin-5

12

5

Small-scale

0.758

High

667131

CG23
G2/mitotic-specific cyclin-3

7

5

Small-scale

0.748

High

460724

CDC4
Cell division control protein 4

24

0

Small-scale

0.736

High

667083

CG22
G2/mitotic-specific cyclin-2

6

5

Small-scale

0.727

High

633252

CKS1
Cyclin-dependent kinases regulatory subunit

7

0

Small-scale

0.714

High

801179

SKP1
Suppressor of kinetochore protein 1

5

0

Small-scale

0.685

High

801183

CDC14
Tyrosine-protein phosphatase CDC14

4

0

Small-scale

0.667

High

667159

CG24
G2/mitotic-specific cyclin-4

3

5

Small-scale

0.660

High

737844

HOG1
Mitogen-activated protein kinase HOG1

3

0

Small-scale

0.656

High

801175

RSP5
E3 ubiquitin-protein ligase RSP5

3

0

Small-scale

0.627

High

667055

CG21
G2/mitotic-specific cyclin-1

2

5

Small-scale

0.626

High

748808

CGS6
S-phase entry cyclin-6

2

5

Small-scale

0.626

High

801187

CDC53
Cell division control protein 53

2

0

Small-scale

0.619

High

585922

CSK21
Casein kinase II subunit alpha

2

2

Small-scale

0.602

High

740572

IME2
Meiosis induction protein kinase IME2/SME1

2

1

Small-scale

0.602

High

574795

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

2

0

Small-scale

0.592

High

632422

CG12
G1/S-specific cyclin CLN2

2

6

Small-scale

0.584

High

526583

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.571

High

801184

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

Small-scale

0.561

High

602436

PHO85
Cyclin-dependent protein kinase PHO85

1

1

Small-scale

0.550

High

780145

SDS22
Protein phosphatase 1 regulatory subunit SDS22

1

0

High-throughput

0.518

High

797919

SDS24
Protein SDS24

1

0

High-throughput

0.518

High

801181

RHO5
GTP-binding protein RHO5

1

0

High-throughput

0.518

High

801186

YL345
Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W [Includes: 6-phosphofructo-2-kinase

1

0

High-throughput

0.518

High

801188

DPH3
Diphthamide biosynthesis protein 3

1

0

High-throughput

0.518

High

801174

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.513

High

801176

PCL6
PHO85 cyclin-6

1

0

High-throughput

0.513

High

622941

CSK22
Casein kinase II subunit alpha'

1

1

Small-scale

0.501

High

801180

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.493

High

645164

PSB4
Proteasome subunit beta type-4

1

0

Small-scale

0.480

High

660785

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

0

Small-scale

0.480

High

743979

RAD23
UV excision repair protein RAD23

1

0

Small-scale

0.480

High

801182

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

Small-scale

0.480

High

523811

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.479

High

150282

RPN13
26S proteasome regulatory subunit RPN13

1

0

Small-scale

0.458

High

801172

RPN1
26S proteasome regulatory subunit RPN1

1

0

Small-scale

0.458

High

801173

RPN10
26S proteasome regulatory subunit RPN10

1

0

Small-scale

0.458

High

801178

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

544719

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

801177

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

801185

DCR2
Phosphatase DCR2

1

0

Small-scale

0.292

High

763149

SC61G
Protein transport protein SSS1

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025