Protein: IME2
Meiosis induction protein kinase IME2/SME1 (EC 2.7.11.1)

Gene: IME2
Organism: Saccharomyces cerevisiae S288C
Interactions: 125
UniProt ID: P32581

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739934

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

2

16

Small-scale

0.789

High

740574

RIM4
Meiotic activator RIM4

2

8

Small-scale

0.778

High

670485

SIS1
Protein SIS1

1

8

High-throughput

0.691

High

740576

NDT80
Meiosis-specific transcription factor NDT80

4

0

Small-scale

0.659

High

740555

IME2
Meiosis induction protein kinase IME2/SME1

1

17

Small-scale

0.647

High

740564

PP2C1
Protein phosphatase 2C homolog 1

1

12

High-throughput

0.647

High

740566

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

19

High-throughput

0.647

High

740604

DMA2
E3 ubiquitin-protein ligase DMA2

1

1

High-throughput

0.647

High

740629

YP150
Putative serine/threonine-protein kinase YPL150W

1

13

High-throughput

0.647

High

675827

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.646

High

740565

MDJ1
DnaJ homolog 1, mitochondrial

1

8

High-throughput

0.646

High

740573

KSP1
Serine/threonine-protein kinase KSP1

1

20

High-throughput

0.646

High

533164

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

2

2

Small-scale

0.633

High

479256

CDC6
Cell division control protein 6

2

13

Small-scale

0.625

High

709325

HRR25
Casein kinase I homolog HRR25

1

10

Small-scale

0.618

High

740605

CRZ1
Transcriptional regulator CRZ1

1

0

High-throughput

0.614

High

740625

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

0

High-throughput

0.614

High

740628

CMR3
Zinc finger protein CRM3

1

0

High-throughput

0.614

High

740572

SIC1
Protein SIC1

2

1

Small-scale

0.602

High

394369

EF1A
Elongation factor 1-alpha

2

6

High-throughput

0.602

High

740615

RRP5
rRNA biogenesis protein RRP5

1

2

High-throughput

0.579

High

739321

ZUO1
Zuotin

1

5

High-throughput

0.575

High

688731

RFA2
Replication factor A protein 2

2

6

Small-scale

0.550

High

636443

IME1
Meiosis-inducing protein 1

1

0

Small-scale

0.549

High

553964

TCPA
T-complex protein 1 subunit alpha

1

12

High-throughput

0.536

High

740577

KOG1
Target of rapamycin complex 1 subunit KOG1

1

7

High-throughput

0.536

High

740578

TCPB
T-complex protein 1 subunit beta

1

15

High-throughput

0.536

High

740591

ASK10
Activator of SKN7 protein 10

1

3

High-throughput

0.536

High

740594

VID30
GID complex subunit 1

1

5

High-throughput

0.536

High

740597

CDH1
APC/C activator protein CDH1

1

18

High-throughput

0.536

High

740617

RGC1
Regulator of the glycerol channel 1

1

3

High-throughput

0.536

High

740624

ACM1
APC/C-CDH1 modulator 1

1

1

High-throughput

0.536

High

740610

MUB1
MYND-type zinc finger protein MUB1

1

0

High-throughput

0.513

High

381963

H4
Histone H4

1

5

Small-scale

0.501

High

416872

CDC25
Cell division control protein 25

1

2

High-throughput

0.501

High

585745

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

1

3

High-throughput

0.501

High

598832

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

7

High-throughput

0.501

High

600669

SEC2
Rab guanine nucleotide exchange factor SEC2

1

3

High-throughput

0.501

High

664423

MCM3
DNA replication licensing factor MCM3

1

17

Small-scale

0.501

High

712958

MCM2
DNA replication licensing factor MCM2

1

15

Small-scale

0.501

High

713250

MCM5
Minichromosome maintenance protein 5

1

14

Small-scale

0.501

High

721357

MCM4
DNA replication licensing factor MCM4

1

15

Small-scale

0.501

High

732024

MLF3
Protein MLF3

1

2

High-throughput

0.501

High

732045

SYKM
Lysine--tRNA ligase, mitochondrial

1

1

High-throughput

0.501

High

740289

PAH1
Phosphatidic acid phosphohydrolase 1

1

2

High-throughput

0.501

High

740556

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

5

High-throughput

0.501

High

740558

KU70
ATP-dependent DNA helicase II subunit 1

1

5

High-throughput

0.501

High

740559

ORC2
Origin recognition complex subunit 2

1

6

Small-scale

0.501

High

740568

MCM7
DNA replication licensing factor MCM7

1

14

Small-scale

0.501

High

740575

ORC6
Origin recognition complex subunit 6

1

1

Small-scale

0.501

High

740581

VHS2
Protein VHS2

1

2

High-throughput

0.501

High

740582

SYA
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.501

High

740585

BUD27
Bud site selection protein 27

1

1

High-throughput

0.501

High

740586

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

5

High-throughput

0.501

High

740595

MCM6
DNA replication licensing factor MCM6

1

17

Small-scale

0.501

High

740599

YG3A
Uncharacterized protein YGR130C

1

15

High-throughput

0.501

High

740600

REXO1
RNA exonuclease 1

1

2

High-throughput

0.501

High

740601

H1
Histone H1

1

1

Small-scale

0.501

High

740603

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.501

High

740606

ORC1
Origin recognition complex subunit 1

1

18

Small-scale

0.501

High

740608

ORC4
Origin recognition complex subunit 4

1

13

Small-scale

0.501

High

740614

YM11A
Transposon Ty1-ML1 Gag polyprotein

1

5

High-throughput

0.501

High

740620

BDF2
Bromodomain-containing factor 2

1

13

High-throughput

0.501

High

740627

SAS10
Something about silencing protein 10

1

2

High-throughput

0.501

High

740633

YN11A
Transposon Ty1-NL1 Gag polyprotein

1

5

High-throughput

0.501

High

740634

YD21A
Transposon Ty2-DR1 Gag polyprotein

1

8

High-throughput

0.501

High

366976

ATPB
ATP synthase subunit beta, mitochondrial

1

15

High-throughput

0.500

High

386636

TBB
Tubulin beta chain

1

7

High-throughput

0.500

High

408304

GAL1
Galactokinase

1

2

High-throughput

0.500

High

452859

ATPA
ATP synthase subunit alpha, mitochondrial

1

15

High-throughput

0.500

High

486099

TBA1
Tubulin alpha-1 chain

1

10

High-throughput

0.500

High

486434

TBA3
Tubulin alpha-3 chain

1

10

High-throughput

0.500

High

531282

METK1
S-adenosylmethionine synthase 1

1

3

High-throughput

0.500

High

592112

VATB
V-type proton ATPase subunit B

1

15

High-throughput

0.500

High

626658

HSP60
Heat shock protein 60, mitochondrial

1

13

High-throughput

0.500

High

740589

TCPQ
T-complex protein 1 subunit theta

1

13

High-throughput

0.500

High

740622

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.500

High

740630

HSP42
Heat shock protein 42

1

3

High-throughput

0.500

High

740636

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.500

High

740583

LST8
Target of rapamycin complex subunit LST8

1

9

High-throughput

0.489

High

626562

PNPP
4-nitrophenylphosphatase

1

0

High-throughput

0.480

High

740571

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.480

High

740587

SUM1
Suppressor of mar1-1 protein

1

0

Small-scale

0.480

High

740590

CDT1
Cell division cycle protein CDT1

1

0

Small-scale

0.480

High

740592

ORC5
Origin recognition complex subunit 5

1

0

Small-scale

0.480

High

740598

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.480

High

740607

ORC3
Origin recognition complex subunit 3

1

0

Small-scale

0.480

High

740612

YAP6
AP-1-like transcription factor YAP6

1

0

High-throughput

0.480

High

740616

RSA3
Ribosome assembly protein 3

1

0

High-throughput

0.480

High

740618

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.480

High

740619

MDM36
Mitochondrial distribution and morphology protein 36

1

0

Small-scale

0.480

High

740623

AB140
tRNA(Thr)

1

0

High-throughput

0.480

High

740626

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.480

High

740632

NDJ1
Non-disjunction protein 1

1

0

High-throughput

0.480

High

709641

BMH1
Protein BMH1

1

7

Small-scale

0.479

High

740563

BMH2
Protein BMH2

1

7

Small-scale

0.479

High

511757

RS24A
Small ribosomal subunit protein eS24A

1

2

High-throughput

0.457

High

734347

YMC1
Mitochondrial glycine transporter YMC1

1

13

High-throughput

0.457

High

739566

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.457

High

740557

CDC13
Cell division control protein 13

1

1

High-throughput

0.457

High

740560

UGA4
GABA-specific permease

1

2

High-throughput

0.457

High

740569

IST2
Increased sodium tolerance protein 2

1

1

High-throughput

0.457

High

740570

AIM3
Altered inheritance of mitochondria protein 3

1

4

High-throughput

0.457

High

740579

HPH2
Protein HPH2

1

2

High-throughput

0.457

High

740588

BBC1
Myosin tail region-interacting protein MTI1

1

3

High-throughput

0.457

High

740593

NBP1
NAP1-binding protein

1

2

High-throughput

0.457

High

740609

NUM1
Nuclear migration protein NUM1

1

16

Small-scale

0.457

High

740635

ISA2
Iron-sulfur assembly protein 2

1

1

High-throughput

0.457

High

510316

HSP77
Import motor subunit, mitochondrial

1

18

High-throughput

0.445

High

523394

HSP71
Heat shock protein SSA1

1

13

High-throughput

0.445

High

544210

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.445

High

740613

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.426

High

740562

TGL1
Sterol esterase TGL1

1

0

High-throughput

0.279

Low

370463

ATIF
F(1)-ATPase inhibitor IF(1), mitochondrial

1

0

High-throughput

0.261

Low

740561

SRPR
Signal recognition particle receptor subunit alpha homolog

1

0

High-throughput

0.261

Low

740567

SKG1
Suppressor of lethality of KEX2 GAS1 double null mutant protein 1

1

0

High-throughput

0.261

Low

740580

FCY21
Purine-cytosine permease FCY21

1

0

High-throughput

0.261

Low

740584

PRM10
Pheromone-regulated membrane protein 10

1

0

High-throughput

0.261

Low

740596

MST27
Multicopy suppressor of SEC21 protein 27

1

0

High-throughput

0.261

Low

740602

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.261

Low

740611

YMD7
Uncharacterized protein YML037C

1

0

High-throughput

0.261

Low

740631

ATP14
ATP synthase subunit H, mitochondrial

1

0

High-throughput

0.261

Low

740637

DFM1
DER1-like family member protein 1

1

0

High-throughput

0.261

Low

740621

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025