Protein: CG22
G2/mitotic-specific cyclin-2

Gene: CG22, CLB2
Organism: Saccharomyces cerevisiae S288C
Interactions: 82
UniProt ID: P24869

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

364352

CDK1
Cyclin-dependent kinase 1

30

20

Small-scale

0.993

High

667079

SWE1
Mitosis inhibitor protein kinase SWE1

6

11

Small-scale

0.948

High

667105

CDH1
APC/C activator protein CDH1

11

20

Small-scale

0.756

High

633234

CKS1
Cyclin-dependent kinases regulatory subunit

8

20

Small-scale

0.746

High

667083

SIC1
Protein SIC1

6

5

Small-scale

0.727

High

479252

CDC6
Cell division control protein 6

5

9

Small-scale

0.711

High

667068

NAP1
Nucleosome assembly protein

3

2

Small-scale

0.674

High

667075

CDC20
APC/C activator protein CDC20

3

20

Small-scale

0.656

High

667070

KIN82
Serine/threonine-protein kinase KIN82

1

3

High-throughput

0.647

High

667088

AURK
Aurora kinase

1

3

Small-scale

0.647

High

667072

BUD3
Bud site selection protein 3

3

0

Small-scale

0.621

High

667110

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

4

High-throughput

0.621

High

667124

NDD1
Nuclear division defective protein 1

2

1

Small-scale

0.620

High

602328

PHO85
Cyclin-dependent protein kinase PHO85

1

20

Small-scale

0.618

High

642327

MCK1
Protein kinase MCK1

1

20

Small-scale

0.618

High

645876

DBF2
Cell cycle protein kinase DBF2

1

7

Small-scale

0.618

High

667051

CG21
G2/mitotic-specific cyclin-1

1

6

Small-scale

0.618

High

667117

STE20
Serine/threonine-protein kinase STE20

1

6

Small-scale

0.618

High

667069

SWI4
Regulatory protein SWI4

2

2

Small-scale

0.612

High

667115

IMA1
Importin subunit alpha

2

2

Small-scale

0.595

High

667103

NET1
Nucleolar protein NET1

2

2

Small-scale

0.585

High

667087

HAL5
Serine/threonine-protein kinase HAL5

1

7

High-throughput

0.579

High

597600

CDC23
Anaphase-promoting complex subunit CDC23

1

8

Small-scale

0.573

High

667093

SSB2
Ribosome-associated molecular chaperone SSB2

2

11

Small-scale

0.571

High

667085

ORC6
Origin recognition complex subunit 6

1

1

Small-scale

0.550

High

667118

FIN1
Filament protein FIN1

1

1

Small-scale

0.550

High

667092

GLE2
mRNA export factor GLE2

1

1

High-throughput

0.536

High

667096

NU159
Nucleoporin NUP159

1

4

High-throughput

0.536

High

667081

ASK1
DASH complex subunit ASK1

1

0

Small-scale

0.527

High

667082

INCE
Inner centromere protein SLI15

1

0

Small-scale

0.527

High

667089

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.513

High

667094

NUP82
Nucleoporin NUP82

1

0

High-throughput

0.513

High

667114

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.513

High

667116

MUK1
Protein MUK1

1

0

High-throughput

0.513

High

664407

MCM3
DNA replication licensing factor MCM3

1

5

Small-scale

0.501

High

667101

ECO1
N-acetyltransferase ECO1

1

1

Small-scale

0.501

High

667104

APC10
Anaphase-promoting complex subunit DOC1

1

1

Small-scale

0.501

High

577267

NSP1
Nucleoporin NSP1

1

6

High-throughput

0.489

High

667112

NU100
Nucleoporin NUP100/NSP100

1

6

High-throughput

0.489

High

667113

NU116
Nucleoporin NUP116/NSP116

1

6

High-throughput

0.489

High

628041

FKBP
FK506-binding protein 1

1

0

High-throughput

0.486

High

667084

NEL1
GTPase-activating protein NEL1

1

0

High-throughput

0.486

High

667119

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.486

High

667120

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.486

High

667091

FIR1
Factor interacting with REF2

1

4

Small-scale

0.481

High

667122

CYK2
Cytokinesis protein 2

1

1

Small-scale

0.481

High

575271

RAD9
DNA repair protein RAD9

1

0

Small-scale

0.480

High

667106

H1
Histone H1

1

0

Small-scale

0.480

High

667071

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.479

High

430784

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.479

High

444430

DED1
ATP-dependent RNA helicase DED1

1

2

Small-scale

0.479

High

460948

LTE1
Guanine nucleotide exchange factor LTE1

1

1

Small-scale

0.479

High

481492

HSP73
Heat shock protein SSA3

1

8

Small-scale

0.479

High

523134

HSP71
Heat shock protein SSA1

1

8

Small-scale

0.479

High

525980

HSP72
Heat shock protein SSA2

1

8

Small-scale

0.479

High

543895

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

Small-scale

0.479

High

636450

ACE2
Metallothionein expression activator

1

5

Small-scale

0.479

High

636911

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

2

Small-scale

0.479

High

645681

HSP74
Heat shock protein SSA4

1

8

Small-scale

0.479

High

666581

DBP1
ATP-dependent RNA helicase DBP1

1

2

Small-scale

0.479

High

667074

SYP1
Suppressor of yeast profilin deletion

1

1

Small-scale

0.479

High

667076

HIR1
Protein HIR1

1

1

Small-scale

0.479

High

667077

HIR2
Protein HIR2

1

1

Small-scale

0.479

High

667078

STE5
Protein STE5

1

1

Small-scale

0.479

High

667080

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

Small-scale

0.479

High

667086

KEL1
Kelch repeat-containing protein 1

1

2

Small-scale

0.479

High

667095

FKH1
Fork head protein homolog 1

1

4

Small-scale

0.479

High

667098

FKH2
Fork head protein homolog 2

1

5

Small-scale

0.479

High

667099

MPG1
Mannose-1-phosphate guanyltransferase

1

1

Small-scale

0.479

High

667102

COM1
DNA endonuclease SAE2

1

1

Small-scale

0.479

High

667111

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

Small-scale

0.479

High

394261

EF1A
Elongation factor 1-alpha

1

0

Small-scale

0.458

High

667073

LRE1
Laminarase-resistance protein LRE1

1

0

Small-scale

0.458

High

667097

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

Small-scale

0.458

High

667108

INN1
Ingression protein 1

1

0

Small-scale

0.458

High

667123

CUE5
Ubiquitin-binding protein CUE5

1

0

Small-scale

0.458

High

667125

YL054
Uncharacterized transcriptional regulatory protein YLL054C

1

0

Small-scale

0.458

High

667100

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

4

Small-scale

0.457

High

667109

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

667121

IVY1
Protein IVY1

1

0

High-throughput

0.279

Low

667107

RM50
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.265

Low

667090

RPN3
26S proteasome regulatory subunit RPN3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025