Protein: IL10
Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF)

Gene: IL10
Organism: Homo sapiens
Interactions: 30
UniProt ID: P22301

Gene Ontology (top 5):
GO:0001818 - negative regulation of cytokine production
GO:0001819 - positive regulation of cytokine production
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0002237 - response to molecule of bacterial origin
GO:0002439 - chronic inflammatory response to antigenic stimulus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

647316

I10R1
Interleukin-10 receptor subunit alpha

11

3

Small-scale

0.980

High

647313

I10R2
Interleukin-10 receptor subunit beta

3

3

Small-scale

0.849

High

647303

IL10
Interleukin-10

2

0

Small-scale

0.738

High

647307

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.586

High

647304

TYY1
Transcriptional repressor protein YY1

2

0

High-throughput

0.580

High

647309

KR108
Keratin-associated protein 10-8

2

2

High-throughput

0.553

High

647318

KRA13
Keratin-associated protein 1-3

2

2

High-throughput

0.553

High

647319

KRA41
Keratin-associated protein 4-1

2

2

High-throughput

0.553

High

647320

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

1

High-throughput

0.536

High

516966

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.515

High

183848

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

0

High-throughput

0.513

High

629058

CCNA2
Cyclin-A2

1

0

High-throughput

0.513

High

647310

LRP2
Low-density lipoprotein receptor-related protein 2

1

0

High-throughput

0.513

High

445124

S10A6
Protein S100-A6

1

1

Small-scale

0.501

High

647305

S100P
Protein S100-P

1

1

Small-scale

0.501

High

647315

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

1

High-throughput

0.489

High

647317

NT2NA
Notch homolog 2 N-terminal-like protein A

1

1

High-throughput

0.481

High

369618

A2MG
Alpha-2-macroglobulin

1

0

Small-scale

0.480

High

609901

SPI1
Transcription factor PU.1

1

2

Small-scale

0.479

High

647306

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.479

High

647311

SPIB
Transcription factor Spi-B

1

2

Small-scale

0.479

High

647312

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

647314

IRF5
Interferon regulatory factor 5

1

1

Small-scale

0.479

High

464810

SP1
Transcription factor Sp1

1

0

Small-scale

0.458

High

300108

GLRX3
Glutaredoxin-3

2

0

High-throughput

0.316

High

456058

CRGD
Gamma-crystallin D

1

0

High-throughput

0.279

Low

481

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

484917

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

Small-scale

0.249

Low

647308

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025